Mixture of dominant PBDE congeners (BDE-47, -99, -100 and -209) at levels noted in human blood dramatically enhances progesterone secretion by ovarian follicles

Karpeta, Anna; Gregoraszczuk, Ewa Ł.

doi:10.4149/endo_2010_02_49

Cited by 31 publications

(14 citation statements)

References 13 publications

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“…Our previously published papers showed that PBDEs can disrupt ovarian steroidogenesis (Gregoraszczuk Q2 et al, 2008a,b;Karpeta and Gregoraszczuk, 2010). Moreover, we showed differences in the action of the parent compound, BDE-47, and its hydroxylated metabolites on ovarian steroidogenesis.…”

Section: Introductionmentioning

confidence: 47%

Different action of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression

2014

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Section: Introductionmentioning

confidence: 47%

Different action of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression

2014

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“…Subchronic exposures to aluminum resulted in reduced serum progestogen concentrations in Wistar rats (Alonso et al 2010). Certain PBDEs have been shown to decrease P 4 synthesis in mouse Leydig tumor cells (Han et al 2012) while other PBDEs have been shown to increase P 4 synthesis in the ovarian follicles of pigs (Karpeta & Gregoraszczuk 2010). Proposed mechanisms of action in the latter study include modulation of key steroidogenic genes, many of which are highly conserved among vertebrates (Karpeta et al 2011).…”

Section: Discussionmentioning

confidence: 99%

The reproductive hormone cycle of adult female American alligators from a barrier island population

Hamlin

Lowers²,

Kohno

et al. 2014

Reproduction

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Comparatively, little data are available detailing the geographic variation that exists in the reproductive endocrinology of adult alligators, especially those living in barrier islands. The Merritt Island National Wildlife Refuge (MI) is a unique barrier island environment and home to the Kennedy Space Center (FL, USA). Seasonal patterns of sex steroids were assessed in adult female American alligators from MI monthly from 2008 to 2009, with additional samples collected at more random intervals in 2006, 2007, and 2010. Plasma 17b-estradiol and vitellogenin concentrations peaked in April, coincident with courtship and mating, and showed patterns similar to those observed in adult female alligators in other regions. Plasma concentrations of progesterone, however, showed patterns distinctly different than those reported for alligator populations in other regions and remained relatively constant throughout the year. Plasma DHEA peaked in July around the time of oviposition, decreased in August, and then remained constant for the remaining months, except for a moderate increase in October. Circulating concentrations of DHEA have not been previously assessed in a female crocodilian, and plasma concentrations coincident with reproductive activity suggest a reproductive and/or behavioral role. Interestingly, plasma testosterone concentrations peaked in May of 2008, as has been shown in female alligator populations in other regions, but showed no peak in 2009, demonstrating dramatic variability from year to year. Surveys showed 2009 to be particularly depauperate of alligator nests in MI, and it is possible that testosterone could serve as a strong indicator of breeding success.

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“…Results from our laboratory have shown an increase in the P4/testosterone (T) ratio but a decrease in the T/E2 ratio, in ovarian follicles suggesting premature luteinization of antral follicles. Removal of the PBDE mixture from cell cultures did not reverse adverse effects [22]. In a follow-up study, we reported changes in the levels of steroidogenic enzymes (e.g., 17 β -hydroxysteroid dehydrogenase (17 β -HSD), cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17), and aromatase (CYP19)) by PBDE congeners 47, 99, and 100 [23].…”

Section: Actions On the Ovarymentioning

confidence: 99%

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction

Gregoraszczuk

Ptak

2013

International Journal of Endocrinology

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Persistent organic pollutants (POPs), such as polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and polybrominated ethers (PBDEs), chloronaftalens (PCNs), and bisphenol A (BPA), are stable, lipophilic pollutants that affect fertility and cause serious reproductive problems, including ovotoxic action, lack of ovulation, premature ovarian failure (POF), or polycystic ovarian syndrome (PCOS). Most of the representatives of POPs influence the activation of transcription factors, not only activation of aromatic hydrocarbon receptor (AhR), but also the steroid hormone receptors. This minireview will focus on a variety of PAH activities in oocyte, ovary, placenta, and mammary gland. The complexity and diversity of factors belonging to POPs and disorders of the reproductive function of women indicate that the impact of environmental pollution as an important determinant factor in fertility should not be minimize.

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Mixture of dominant PBDE congeners (BDE-47, -99, -100 and -209) at levels noted in human blood dramatically enhances progesterone secretion by ovarian follicles

Cited by 31 publications

References 13 publications

Different action of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression

Different action of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) and its hydroxylated metabolites on ERα and ERβ gene and protein expression

The reproductive hormone cycle of adult female American alligators from a barrier island population

Endocrine-Disrupting Chemicals: Some Actions of POPs on Female Reproduction

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