Mixt-chronic viral hepatitis in the republic of Sakha (Yakutia)

Semenov, S.I.; Fadeev, Artem; Pisareva, Maria; Komissarov, Andrey; Egorova, Anna; Степанов, К.М.; Rumyantseva, T. D.

doi:10.25789/ymj.2020.71.18

Cited by 1 publication

(7 citation statements)

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“…Anti-HDV antibodies were detected in approximately a third of HBsAg-positive participants. These data are consistent with prevalence estimates for the general population of Yakutia based on studies performed more than twenty years ago [ 16 , 44 ], indicating the wide and stable circulation of HDV in the region.…”

Section: Discussionsupporting

confidence: 90%

“…In the current study, no single case of HBsAg detection was identified among participants aged less than 30 years old. The overall HBsAg prevalence also decreased significantly, from 8.0% in the early 2000s [ 16 ] to 4.6% in the current study ( p = 0.0188). Such a decrease in the HBV prevalence appears to be related to the universal newborn vaccination program that started in 1998 and the adult vaccination campaign that started in 2006.…”

Section: Discussionsupporting

confidence: 44%

“…Our data indicate that the prevalence of HBV, HDV and HCV is still high among the indigenous populations of the Arctic zone of Yakutia. The analysis of the published data suggests that the last study on the prevalence of these infections in the Arctic regions of Yakutia was performed about 20 years ago [ 16 ]. A comparison of the results of the current study with those obtained 20 years ago demonstrates a clear trend toward a decline in HBV prevalence.…”

Section: Discussionmentioning

confidence: 99%

“…A comparison of the results of the current study with those obtained 20 years ago demonstrates a clear trend toward a decline in HBV prevalence. In the early 2000s, the HBsAg detection rate in individuals aged 15–19 years old was 21.6% [ 16 ]. In the current study, no single case of HBsAg detection was identified among participants aged less than 30 years old.…”

Section: Discussionmentioning

confidence: 99%

“…The remoteness from the regional centers of the republic, together with either absent or poor transport accessibility, as well as low population density (0.32 people/km 2 [ 14 ]) critically and negatively influence the standard of living of the local population, including the availability of the universal and specialized medical care compared to other regions of Russia and migrant population within the region, which is concentrated mainly in cities. This problem is most acute in the Arctic regions of Yakutia, where the population density does not exceed 0.08 people/km 2 [ 15 ], and the population is largely composed of the indigenous people of the North—Evenks, Evens and Yukaghirs [ 16 ]. The prevalence of the hepatitis B virus (HBV), hepatitis D virus (HDV) and hepatitis C virus (HCV) in these populations varies significantly depending on the studied region and/or ethnic group [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of Viral Hepatitis in the Indigenous Populations of the Arctic Zone of the Republic of Sakha (Yakutia)

Kichatova,

Lopatukhina,

Potemkin

et al. 2024

Microorganisms

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The indigenous populations of the Arctic regions of Russia experience the lowest coverage of health-related services. We assessed the prevalence of hepatitis A, B, C, D and E viruses (HAV, HBV, HCV, HDV and HEV) among 367 healthy adult Native people of the Arctic zone of Yakutia. The HAV seroprevalence was above and increased with age. The anti-HEV IgM and IgG antibody detection rates were 4.1% and 2.5%, respectively. The average HBsAg detection rate was 4.6%, with no positive cases identified in participants aged under 30 years, confirming the effectiveness of the newborn vaccination program that began in 1998. Anti-HDV antibodies were detected in 29.4% of HBsAg-positive cases. The anti-HCV and HCV RNA detection rates peaked in the age cohort of 50–59 years (10.8% and 3.9%). No statistically significant gender differences in the prevalence of different viral hepatitis were observed. The time-scaled phylogenetic analysis demonstrated that all HBV genotype A and D strains isolated in this study were autochthonous and had an estimated most common recent ancestor (MCRA) age of around the 11th to 14th century. Unlike HBV, the HCV strains of subtypes 1b, 2a and 2k/1b were introduced from other regions of Russia in the 1980s and 1990s. The HCV 1b sequence analysis revealed a series of transmission events. In conclusion, these data emphasize the urgent need for expanded viral hepatitis screening and care programs in the indigenous populations of the Arctic zone of Yakutia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%