Mixing high-viscosity fluids via acoustically driven bubbles

Orbay, Sinem; Özçelik, Adem; Lata, James P.; Kaynak, Murat; Wu, Mengxi; Huang, Tony Jun

doi:10.1088/0960-1317/27/1/015008

Cited by 69 publications

(44 citation statements)

References 64 publications

(88 reference statements)

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“…In a typical acoustofluidic system, either Rayleigh surface acoustic waves (SAWs) or bulk waves traveling on the surface or in the bulk of a microfluidic device, respectively, is the dominant wave propagation mode. Such an acoustic actuation mechanism can force the microchannel walls, microbubbles, or sharp‐edge elastic geometries embedded inside the microfluidic device to oscillate. A result of this oscillation is a nonperiodic fluid motion generated near the oscillating object in its surrounding liquid.…”

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confidence: 99%

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Acoustofluidics, the field of microscale fluid manipulation using acoustics, has utility in many applications, including drug delivery, [1,2] microorganism manipulation, [3][4][5] analyte mixing, [6][7][8][9] and lab-on-a-chip fluid pumping. [10,11] In a typical acoustofluidic system, either Rayleigh surface acoustic waves (SAWs) or bulk waves traveling on the surface or in the bulk of a microfluidic device, respectively, is the dominant wave propagation mode.

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confidence: 99%

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Dancing with the Cells: Acoustic Microflows Generated by Oscillating Cells

Salari

Appak-Baskoy

Ezzo

et al. 2019

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The interaction of a sound or ultrasound wave with an elastic object, such as a microbubble, can give rise to a steady‐state microstreaming flow in its surrounding liquid. Many microfluidic strategies for cell and particle manipulation, and analyte mixing, are based on this type of flow. In addition, there are reports that acoustic streaming can be generated in biological systems, for instance, in a mammalian inner ear. Here, new observations are reported that individual cells are able to induce microstreaming flow, when they are excited by controlled acoustic waves in vitro. Single adherent cells are exposed to an acoustic field inside a microfluidic device. The cell‐induced microstreaming is then investigated by monitoring flow tracers around the cell, while the structure and extracellular environment of the cell are altered using different chemicals. The observations suggest that the maximum streaming flow induced by an MDA‐MB‐231 breast cancer cell can reach velocities on the order of mm s−1, and this maximum velocity is primarily governed by the overall cell stiffness. Therefore, such cell‐induced microstreaming measurements, including flow pattern and velocity magnitude, may be used as label‐free proxies of cellular mechanical properties, such as stiffness.

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confidence: 99%

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confidence: 99%

Dancing with the Cells: Acoustic Microflows Generated by Oscillating Cells

Salari

Appak-Baskoy

Ezzo

et al. 2019

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“…where u x and u y are the velocity components at the bubble position; that is, they are the x and y components of u(x, y)| (x,y)=(x b ,y b ) as given by Equations (13)(14)(15) [33]. The jet direction θ j for a bubble collapse at any point in the fluid can be calculated using Equation (16). Calculations of jet direction for bubble collapse at different points within the four polygons are displayed by vector fields in Figure 4a, 4c, 4e, and 4g.…”

Section: Jet Directionmentioning

confidence: 99%

Jet direction in bubble collapse within rectangular and triangular channels

Molefe

Peters

2019

Phys. Rev. E

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A vapor bubble collapsing near a solid boundary in a liquid produces a liquid jet that points toward the boundary. The direction of this jet has been studied for boundaries such as flat planes and parallel walls enclosing a channel. Extending these investigations to enclosed polygonal boundaries, we experimentally measure jet direction for collapsing bubbles inside a square and an equilateral triangular channel. Following the method of Tagawa and Peters (Phys. Rev. Fluids 3, 081601, 2018) for predicting the jet direction in corners, we model the bubble as a sink in a potential flow and demonstrate by experiment that analytical solutions accurately predict jet direction within an equilateral triangle and square. We further use the method to develop predictions for several other polygons, specifically, a rectangle, an isosceles right triangle, and a 30 • -60 • -90 • right triangle. arXiv:1910.08970v1 [physics.flu-dyn]

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“…Acoustics provide a noninvasive and robust transduction mechanism that has been widely used in micromixing, micropumping, particle or cell separation, and manipulation, protein crystal patterning, microfluidic switches, droplet production, drug delivery, and actuation of micro‐ and nanoswimmers . Acoustic wave–induced microvortices around solid structures and bubbles have been used to perform manipulation of small objects .…”

Section: Introductionmentioning

confidence: 99%

“…Acoustics provide a noninvasive and robust transduction mechanism that has been widely used in micromixing, [6][7][8] micropumping, [9] particle or cell separation, [10,11] and manipulation, [12][13][14][15] protein crystal patterning, [16] microfluidic…”

Section: Introductionmentioning

confidence: 99%

3D Manipulation and Imaging of Plant Cells using Acoustically Activated Microbubbles

et al. 2019

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The precise manipulation of single cells and organisms opens exciting new possibilities for biological research. In this work, an acoustic rotational manipulation method for imaging single cells of different plant species (pollen grains of Lilium longiflorum and Arabidopsis thaliana) is demonstrated. Acoustically activated microbubbles generate radiation forces as well as microvortices in the aqueous medium, which allow various specimens to be trapped and precisely rotated. The rotational behavior of individual plant cells is studied and their motion to facilitate 3D fluorescent microscopy is controlled. The use of this manipulation technique for high‐resolution 3D optical reconstructions of nontransparent samples is demonstrated. The applicability of this method for open‐microchannel arrangement, which may enable multiplexed 3D access to samples for microsurgery and injection, is further demonstrated.

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Mixing high-viscosity fluids via acoustically driven bubbles

Cited by 69 publications

References 64 publications

Dancing with the Cells: Acoustic Microflows Generated by Oscillating Cells

Dancing with the Cells: Acoustic Microflows Generated by Oscillating Cells

Jet direction in bubble collapse within rectangular and triangular channels

3D Manipulation and Imaging of Plant Cells using Acoustically Activated Microbubbles

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