Mixing Analysis for a Fermentation Broth of the Fungus <i>Beauveria bassiana</i> under Different Hydrodynamic Conditions in a Bioreactor

Núñez-Ramírez, Diola Marina; Valencia-López, José J.; Calderas, Fausto; Solís-Soto, Aquiles; López-Miranda, Javier; Medrano-Roldán, Hiram; Medina‐Torres, Luis

doi:10.1002/ceat.201200130

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…2b make the microorganisms grow faster. After the day at which the maximum viscosity is exhibited, the bacterial population begins to decrease with the bioleaching time, as observed in other microorganism systems [3,5,28], and in the culture medium rheology shown in Fig. S2, this is reinforced by the fact that, as shown in Tabs.…”

Section: Rheological Responsesupporting

confidence: 59%

“…Mineral pulps undergoing bioleaching processes exhibit both elastic and viscous properties simultaneously [3,5]. Small-amplitude oscillatory shear flow (SAOS) tests can help in the optimization of bioleaching processes of mineral concentrates.…”

Section: Small-amplitude Oscillatory Shear Flowmentioning

confidence: 99%

“…Additionally, metal bioleaching processes with acidophilic bacteria have been proven to be an efficient, economical, and environmentally friendly option [1][2][3]. In the treatment of mineral concentrates by means of bioleaching in stirred-tank bioreactors, rheological characterization of the mineral pulps is necessary [3,4], as well as the hydrodynamics analysis where the bioleaching kinetics is carried out [5]. Basically, bioleaching of mineral ores consists in the dissolution of metals, present as a complex in a solid matrix, into a liquid phase through the catalytic action of acidophilic microorganisms subjected to strong acidic conditions.…”

Section: Introductionmentioning

confidence: 99%

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Rheology and Hydrodynamics of Iron Ore Mineral Pulps during a Bioleaching Process in a Continuous Stirred‐Tank Reactor

et al. 2023

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The rheological response and the computational hydrodynamic continuous stirred‐tank behavior were analyzed to increase the understanding of the bioleaching process in mineral pulps. The rheological properties of the mineral pulps showed that a smaller particle size increases the magnitude of the rheological parameters, shortens the bioleaching process time, and, indirectly, increases the concentration of bacteria in the medium, thus augmenting the gel strength. The bioreactor hydrodynamics results revealed that the best dual‐impeller configuration corresponds to a Rushton (top)/Maxflo (bottom) configuration, generating power savings of ∼9 %. Finally, when analyzing apparent viscosity maps, velocity fields, and streamlines at different stirring speeds, enhanced hydrodynamic conditions were observed at 400 rpm.

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Section: Rheological Responsesupporting

confidence: 59%

Section: Small-amplitude Oscillatory Shear Flowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rheology and Hydrodynamics of Iron Ore Mineral Pulps during a Bioleaching Process in a Continuous Stirred‐Tank Reactor

et al. 2023

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“…Specifically with respect to filamentous fungi fermentations, CFD models are used in order to understand the impact of shear stress on the morphology of the organism as well as for the mass transfer from the bulk solution to the organisms [81–83]. But the real potential of CFD models is, according to us, the coupling of CFD models with biological kinetic reaction models.…”

Section: Discussionmentioning

confidence: 99%

Bis‐arylidene Oxindoles as Anti‐Breast‐Cancer Agents Acting via the Estrogen Receptor

et al. 2014

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We report a new family of bis-arylidene oxindole derivatives that show highly selective estrogen receptor (ER)-mediated anticancer activity at low-nanomolar concentrations in ER-positive (ER+) breast cancer cells. In terms of cell growth inhibition, IC50 values for these compounds in ER+ breast cancer cells are two to three orders of magnitude lower than in ER-negative (ER-) breast cancer cells and non-cancer cells. In comparison with known bis-arylidene drugs, these compounds are at least three orders of magnitude more toxic than tamoxifen and 1.5-4-fold more toxic than 4-hydroxytamoxifen in ER+ MCF-7 cancer cells. These oxindoles inhibit ER transactivation, and their anticancer activities are inhibited in ER-depleted MCF-7 cells. Some of these nonsteroidal molecules also exhibit essential properties of selective ER down-regulation. From the development of two series of bis-arylidene oxindole-based compounds, we report a new series of anticancer agents for estrogen-responsive breast cancer.

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“…A few reports on growth requirements and shake flask culture of B. bassiana strains show the best growth and germination in complex media (Bidochka et al [ 1987 ]; Chong-Rodríguez et al [ 2011 ]; Hegedus et al [ 1990 ]; Humphreys et al [ 1990 ]; Pham et al [ 2009 ]; Rombach [ 1989 ]; Safavi et al [ 2007 ]; Samsináková [ 1966 ]; Thomas et al [ 1987 ]; Vega et al [ 2003 ]). However, only a few publications deal with the production of mycelium (Núñez-Ramírez et al [ 2012 ]) and the production of BS in complex (Humphreys et al [ 1989 , 1990 ]) and mineral media (Lane et al [ 1991 ]) by submerged fermentation, respectively. Endophytic B. bassiana strains can exist asymptomatically in a variety of plants like banana (Akello et al [ 2008 ]), opium poppies (Quesada-Moraga et al [ 2006 ]), maize (Bing and Lewis [ 1992 ]) and sorghum (Tefera and Vidal [ 2009 ]).…”

Section: Introductionmentioning

confidence: 99%

Screening of liquid media and fermentation of an endophytic Beauveria bassiana strain in a bioreactor

2014

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A novel approach for biological control of insect pests could be the use of the endophytic entomopathogenic Beauveria bassiana isolate ATP-02. For the utilization of the endophyte as a commercial biocontrol agent, the fungus has to be mass-produced. B. bassiana was raised in shake flask cultures to produce high concentrations of total spores (TS), which include blastospores (BS) and submerged conidiospores (SCS). The highest concentration of 1.33×109 TS/mL and the highest yield of 5.32×1010 TS/g sucrose was obtained in the TKI broth with 5% sugar beet molasses which consists of 50% sucrose as a carbon source. In spite of the lower sugar concentration (2.5%) the amount of TS could be increased up to 11-times in contrast to the cultivation with 5% sucrose. The scale-up to a 2 L stirred tank reactor was carried out at 25°C, 200–600 rpm and 1 vvm at pH 5.5. A TS yield of 5.2×1010 TS/g sucrose corresponding to a SCS yield of 0.2×1010 SCS/g sucrose was obtained after 216 h. With regards to the culture medium the cost of 1012 TS amounts to 0.24 €. Plutella xylostella larvae, which were fed with oilseed rape leaves treated with spores from fermentation resulted in 77 ± 5% mortality. Moreover, spores from submerged cultivation were able to colonize oilseed rape leaves via leaf application. This is the first report of fermentation of an endophytic B. bassiana strain in a low-cost culture medium to very high yields of TS.

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Mixing Analysis for a Fermentation Broth of the Fungus Beauveria bassiana under Different Hydrodynamic Conditions in a Bioreactor

Cited by 12 publications

References 28 publications

Rheology and Hydrodynamics of Iron Ore Mineral Pulps during a Bioleaching Process in a Continuous Stirred‐Tank Reactor

Rheology and Hydrodynamics of Iron Ore Mineral Pulps during a Bioleaching Process in a Continuous Stirred‐Tank Reactor

Bis‐arylidene Oxindoles as Anti‐Breast‐Cancer Agents Acting via the Estrogen Receptor

Screening of liquid media and fermentation of an endophytic Beauveria bassiana strain in a bioreactor

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