Mixed Spatial and Movement Representations in the Primate Posterior Parietal Cortex

Hadjidimitrakis, Kostas; Bakola, Sophia; Wong, Yan T.; Hagan, Maureen A.

doi:10.3389/fncir.2019.00015

Cited by 38 publications

(42 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it represents a region involved in multiple functions. Besides planning and execution of movements and eye movements ( Jeannerod et al, 1994 ; Sakata et al, 1997 ; Seo et al, 2009 ), it is also involved in different aspects of sensorimotor integration, and also in spatial attention ( Andersen et al, 1985 ; Andersen, 1995 ; Colby and Duhamel, 1991 ; Duhamel et al, 1998 ; Grefkes and Fink, 2005 ; Grefkes et al, 2002 ; Bremmer et al, 2001 ; Pessoa et al, 2003 ; Hadjidimitrakis et al, 2019a ). Anatomically, the IPS is a major landmark on the lateral surface of the macaque parietal lobe.…”

Section: Introductionmentioning

confidence: 99%

Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

Niu

Impieri

Rapan

et al. 2020

eLife

View full text Add to dashboard Cite

The intraparietal sulcus (IPS) is structurally and functionally heterogeneous. We performed a quantitative cyto- and receptor architectonical analysis to provide a multimodal map of the macaque IPS. We identified 17 cortical areas, including novel areas PEipe, PEipi (external and internal subdivisions of PEip), and MIPd. Multivariate analyses of receptor densities resulted in a grouping of areas based on the degree of (dis)similarity of their receptor architecture: a cluster encompassing areas located in the posterior portion of the IPS and associated mainly with the processing of visual information, a cluster including areas found in the anterior portion of the IPS and involved in sensorimotor processing, and an 'intermediate' cluster of multimodal association areas. Thus, differences in cyto- and receptor architecture segregate the cortical ribbon within the IPS, and receptor fingerprints provide novel insights into the relationship between the structural and functional segregation of this brain region in the macaque monkey.

show abstract

Section: Introductionmentioning

confidence: 99%

Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

Niu

Impieri

Rapan

et al. 2020

eLife

View full text Add to dashboard Cite

show abstract

“…In primates, the posterior parietal cortex (PPC) constitutes the end stage of the dorsal visual pathway and as such, it is notably involved in visuospatial and visuomotor functions (Buneo and Andersen 2006 ; Freedman and Ibos 2018 ; Hadjidimitrakis et al 2019a , b ). Most of what we know about how those functions are implemented in the PPC emanates from invasive (anatomical and electrophysiological) studies performed in macaque monkeys.…”

Section: Introductionmentioning

confidence: 99%

Wide-field retinotopy reveals a new visuotopic cluster in macaque posterior parietal cortex

et al. 2020

View full text Add to dashboard Cite

We investigated the visuotopic organization of macaque posterior parietal cortex (PPC) by combining functional imaging (fMRI) and wide-field retinotopic mapping in two macaque monkeys. Whole brain blood-oxygen-level-dependent (BOLD) signal was recorded while monkeys maintained central fixation during the presentation of large rotating wedges and expending/contracting annulus of a “shaking” fruit basket, designed to maximize the recruitment of PPC neurons. Results of the surface-based population receptive field (pRF) analysis reveal a new cluster of four visuotopic areas at the confluence of the parieto-occipital and intra-parietal sulci, in a location previously defined histologically and anatomically as the posterior intra-parietal (PIP) region. This PIP cluster groups together two recently described areas (CIP1/2) laterally and two newly identified ones (PIP1/2) medially, whose foveal representations merge in the fundus of the intra-parietal sulcus. The cluster shares borders with other visuotopic areas: V3d posteriorly, V3A/DP laterally, V6/V6A medially and LIP anteriorly. Together, these results show that monkey PPC is endowed with a dense set of visuotopic areas, as its human counterpart. The fact that fMRI and wide-field stimulation allows a functional parsing of monkey PPC offers a new framework for studying functional homologies with human PPC.

show abstract

“…In the macaque PPC, it is now clear that oculomotor and visuomanual signals are mixed within areas either primarily involved in eye (Dickinson et al, 2003) or arm movements (Battaglia-Mayer et al, 2001;Archambault et al, 2009). While the evidence suggests cross-modal integration and gradual transitions from one functional domain to another in the macaque PPC (Hadjidimitrakis et al, 2019), in the marmoset PPC no such gradual change in neuronal activity or evoked response (Ghahremani et al, 2019) were observed. Taken together, the three lines of evidence supports the existence of a marmoset homologue of the macaque LIP in the PPC and suggest that this homologue may be located differently with reference to the IPS.…”

Section: Discussionmentioning

confidence: 78%

Single unit activity in marmoset posterior parietal cortex in a gap saccade task

Selvanayagam

Ghahremani

et al. 2019

Preprint

View full text Add to dashboard Cite

Abnormal saccadic eye movements can serve as biomarkers for patients with several neuropsychiatric disorders. To investigate cortical control mechanisms of saccadic responses, the common marmoset (Callithrix jacchus) is a promising non-human primate model. Their lissencephalic brain allows for accurate targeting of homologues of sulcal areas in the macaque brain. Here we recorded single unit activity in the posterior parietal cortex of two marmosets using chronic microelectrode arrays, while the monkeys performed a saccadic task with Gap trials (stimulus onset lagged fixation point offset by 200ms) interleaved with Step trials (fixation point disappeared when the peripheral stimulus appeared). Both marmosets showed a gap effect-shorter saccadic reaction times (SRTs) in Gap vs.Step trials. On average, stronger gapperiod response across the entire neuronal population preceded shorter SRTs on trials with contralateral targets, although this correlation was stronger among the 15% 'gap neurons', which responded significantly during the gap. We also found 39% 'target neurons' with significant visual target-related responses, which were stronger in Gap trials and correlated with the SRTs better than the remaining cells. Compared with slow saccades, fast saccades were preceded by both stronger gap-related and target-related response in all PPC neurons, regardless of whether such response reached significance. Our findings suggest that the PPC in the marmoset contains an area that is involved in the modulation of saccadic preparation and plays roles comparable to those of area LIP in macaque monkeys in eye movements. SIGNIFICANCE STATEMENTAbnormal saccadic eye movements can serve as biomarkers for different neuropsychiatric disorders. So far, processes of cerebral cortical control of saccades are not fully understood. Non-human primates are ideal models for studying such processes, and the marmoset is especially advantageous since their smooth cortex permits laminar analyses of cortical microcircuits. Using electrode arrays implanted in the posterior parietal cortex of marmosets, we found neurons responsive to key periods of a saccadic task in a manner that contribute to cortical modulation of saccadic preparation. Notably, this signal was correlated with subsequent saccadic reaction times and was present in the entire neuronal population. We suggest that the marmoset model will shed new light on the cortical mechanisms of saccadic control.

show abstract

Mixed Spatial and Movement Representations in the Primate Posterior Parietal Cortex

Cited by 38 publications

References 119 publications

Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus

Wide-field retinotopy reveals a new visuotopic cluster in macaque posterior parietal cortex

Single unit activity in marmoset posterior parietal cortex in a gap saccade task

Contact Info

Product

Resources

About