Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?

Sarraf, Maria; Yeong, Chai Hong; Hosseini, Hamid Reza Madaah; Saber‐Samandari, Saeed; Basirun, Wan Jefrey; Tsuzuki, Takuya

doi:10.1016/j.ceramint.2020.09.177

Cited by 31 publications

(24 citation statements)

References 343 publications

(402 reference statements)

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“…Self-assembled nanotube arrays grown using anodic oxidation have been of particular interest due to the cost efficiency and ease of fabrication, combined with the exceptional electrical, optical, structural, and thermal properties exhibited by these nanotubes. The anodization layering process produces a continuous array of TiO 2 nanotubes vertically aligned on the surface of titanium alloy [ 205 – 207 ].…”

Section: Potential Of Titanium Alloys For Regenerative Medicine and Nanomedicinementioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of α, β, and α + β. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. Graphic abstract

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Section: Potential Of Titanium Alloys For Regenerative Medicine and Nanomedicinementioning

confidence: 99%

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

et al. 2021

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“…Depending on the amount and type of alloying element, the anodization conditions or the tube growth range can differ to some extent in comparison to Ti anodized in the same electrolyte and under similar conditions. For more details, the reader is referred to the above-mentioned references and the dedicated reviews for anodization of biomedical alloys [ 97 , 98 , 99 , 100 ].…”

Section: Anodic Tio 2 Nanotubesmentioning

confidence: 99%

Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

et al. 2021

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TiO2 nanostructures and more specifically nanotubes have gained significant attention in biomedical applications, due to their controlled nanoscale topography in the sub-100 nm range, high surface area, chemical resistance, and biocompatibility. Here we review the crucial aspects related to morphology and properties of TiO2 nanotubes obtained by electrochemical anodization of titanium for the biomedical field. Following the discussion of TiO2 nanotopographical characterization, the advantages of anodic TiO2 nanotubes will be introduced, such as their high surface area controlled by the morphological parameters (diameter and length), which provides better adsorption/linkage of bioactive molecules. We further discuss the key interactions with bone-related cells including osteoblast and stem cells in in vitro cell culture conditions, thus evaluating the cell response on various nanotubular structures. In addition, the synergistic effects of electrical stimulation on cells for enhancing bone formation combining with the nanoscale environmental cues from nanotopography will be further discussed. The present review also overviews the current state of drug delivery applications using TiO2 nanotubes for increased osseointegration and discusses the advantages, drawbacks, and prospects of drug delivery applications via these anodic TiO2 nanotubes.

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“…Therefore, there is a growing interest for complementary methods to prevent or even cure medical-related infections avoiding antibiotic therapy. A change in the surface structure decreases the bacterial activity on the implant [70].…”

Section: The Antibacterial Activity Of Np Ag-deposited Into Ntt Used mentioning

confidence: 99%

Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants

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et al. 2021

Metals

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The main disadvantage of the implants is the associated infections. Therefore, in the long term, the possibility of improving the antibacterial capacity of different types of implants (dental, orthopedic) is being researched. The severity of the problem lies in the increasing bacterial resistance and finding appropriate alternative treatments for infectious diseases, which is an important research field nowadays. The purpose of this review is to draw a parallel between different studies analyzing the antibacterial activity and mechanism of silver nanoparticles (NP Ag) deposited on the titanium nanotubes (NTT), as well as the analysis of the NP Ag toxicity. This review also provides an overview of the synthesis and characterization of TiO2-derived nanotubes (NT). Thus, the analysis aims to present the existing knowledge to better understand the NP Ag implants benefits and their antibacterial activity.

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Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?

Cited by 31 publications

References 343 publications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

Silver-Deposited Nanoparticles on the Titanium Nanotubes Surface as a Promising Antibacterial Material into Implants

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