Mixed Ovarian Tumor Composed of Brenner Tumor and Adult-Type Granulosa Cell Tumor: A Case Report of a Very Rare Mixed Ovarian Tumor and a Review of the Literature

Tamás, Judit; Vereczkey, Ildikó; Tóth, Erika; Csernák, Erzsébet; Purcsi, Katalin; Pete, Imre

doi:10.1177/1066896917744877

Cited by 4 publications

(6 citation statements)

References 16 publications

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“…[ 2 ] In the case presented here, a coexistence of AGCT with fibroma in the right ovary and Brenners tumor in the left ovary was seen. On extensive search of the literature, only a single case report on the synchronous existence of granulosa cell tumor and Brenner tumor in the same ovary was found;[ 7 ] however, in our case, both tumors coexisted but in contralateral ovaries.…”

Section: Discussionmentioning

confidence: 58%

“…According to the World Health Organization (WHO), the presence of two or more epithelial cell types in an ovarian epithelial neoplasm, where the minor component constitutes at least 10% of the tumor volume, warrants a designation of mixed epithelial tumor. [ 7 ] Sex cord-stromal neoplasms account for approximately 8% of all ovarian tumors. These are composed of ovarian tumors with granulosa cells, theca cells, and/or fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

“…Rather a single, recurrent somatic mutation in the FOXL2 gene has been identified in a large proportion of AGCTs studied and is used to distinguish between AGCT from both nonsex cord-stromal tumors and other tumors in the sex cord-stromal category. [ 7 ] All granulosa cell tumors have malignant potential with the capacity to extend beyond the ovary or recur after surgical removal. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, obtaining good-quality sections is a challenge; therefore, the reporting relies heavily on the competence of the pathologists and the technician. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Occurrence of Adult Granulosa Cell Tumor with Fibroma in One Ovary and Brenner Tumor in Other Ovary: An Extremely Unusual Case

Yadav

Pujani

Singh

et al. 2023

Journal of Mid-Life Health

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Ovarian tumors are a common form of neoplasia in women and it accounts for about 30% of female genital cancers. A coexistence of ovarian tumors with the same histogenetic origin such as germ cell or epithelial or sex cord stromal, but different histologic subtype is relatively common, whereas a synchronous occurrence of tumors with different histogenetic origin is rare. We report a case of 58-year-old woman with the synchronous presentation of adult granulosa cell tumor with fibroma (ovarian tumors with the same origin (sex cord stromal) but different histologic type) in one ovary and Brenner tumor (epithelial origin) in other ovary. Our patient presented with postmenopausal bleeding and was diagnosed with this rare combination of ovarian tumors on histopathology supplemented with immunohistochemistry. On extensive literary search, there is only a single report of mixed ovarian tumor composed of Brenner tumor and adult-type granulosa cell tumor. Our case is different from the above-mentioned report as although, in our patient both tumors coexisted, but in contralateral ovaries.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Moreover, obtaining good-quality sections is a challenge; therefore, the reporting relies heavily on the competence of the pathologists and the technician. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Synchronous Occurrence of Adult Granulosa Cell Tumor with Fibroma in One Ovary and Brenner Tumor in Other Ovary: An Extremely Unusual Case

Yadav

Pujani

Singh

et al. 2023

Journal of Mid-Life Health

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“…A review of the literature identified 19 cases of ovarian epithelial neoplasms, ranging from benign to malignant, that were combined with an AGCT 12–30 . Of the 20 reported cases (including our case), 13 presented with a grossly evident nodule or mass-like area of granulosa cell proliferation, while 7 cases did not display a visible granulosa cell mass (Table 1).…”

Section: Discussionmentioning

confidence: 94%

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Guerrieri

Hudacko

Anderson

2022

International Journal of Gynecological Pathology

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We report a case of a cystic ovarian neoplasm in a 76-yr-old female composed of 2 distinct and intimately associated components: a macrocystic adult granulosa cell tumor (AGCT) and a serous borderline tumor. The granulosa cell nature of the tumor was confirmed with positive immunohistochemical staining for inhibin, calretinin, and WT1, while the neoplastic nature of the granulosa cell proliferation was supported by the presence of a point mutation of the FOXL2 gene. A review of 19 previously reported mixed AGCT and epithelial neoplasms of the ovary is included. Of the eight mixed AGCT and epithelial tumors, including our case, that were tested for FOXL2 mutation, 4 of the 5 mutation-positive cases were notable for demonstrating a macroscopically visible nodule or mass of AGCT at the time of gross examination, while 2 of the 3 mutation-negative cases lacked a mass-producing granulosa cell component. This feature by itself may be sufficient to predict the true neoplastic nature of the granulosa cell proliferation. This is the first reported case of a composite neoplastic AGCT and serous borderline tumor. We also discuss the current histogenetic models for these rare mixed AGCT and epithelial tumors.

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Ultrasonographic and clinicopathologic features of benign Brenner tumors of the ovary*

Wang

Zhou

2022

Oncology and Translational Medicine

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ObjectiveThe aim of this study was to summarize and analyze the ultrasonographic and clinicopathologic features of benign brenner tumors of the ovary.MethodsForty-six patients with brenner tumors of the ovary were included, and the imaging and pathologic features of the tumors were analyzed.ResultsThirty-eight cases were unilateral, while eight cases were bilateral. The tumors were located only in the left ovary in 32 patients and in the right ovary in six patients. The median diameter of the tumors was 62 mm, and the diameter ranged from 15 to 270 mm. Vascular tumors were not observed. Most of the tumors (22/46) showed micro-perfusion, while 16 tumors showed no blood flow signal. Acoustic signal shadows after the cysts were observed in 26 tumors, accounting for 57% of all brenner tumors. Fourteen patients showed unilocular or multilocular tumors with no distinct characteristics on ultrasonography. Sixteen masses showed a multilocular solid structure, accompanied by calcification and a post-mass shadow; the solid structure showed mild-to-moderate vascularization on Doppler examination. Sixteen masses showed a pure solid structure, accompanied by calcification, resulting in an acoustic shadow behind the tumor; the solid structure showed mild-to-moderate vascularization on Doppler examination.ConclusionSome ultrasonographic features, including calcification with shadow, poor blood circulation of solid components, and mass localization, are helpful in the diagnosis of benign brenner tumors.

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Mixed Ovarian Tumor Composed of Brenner Tumor and Adult-Type Granulosa Cell Tumor: A Case Report of a Very Rare Mixed Ovarian Tumor and a Review of the Literature

Cited by 4 publications

References 16 publications

Synchronous Occurrence of Adult Granulosa Cell Tumor with Fibroma in One Ovary and Brenner Tumor in Other Ovary: An Extremely Unusual Case

Synchronous Occurrence of Adult Granulosa Cell Tumor with Fibroma in One Ovary and Brenner Tumor in Other Ovary: An Extremely Unusual Case

Composite FOXL2 Mutation-positive Adult Granulosa Cell Tumor and Serous Borderline Tumor of the Ovary

Ultrasonographic and clinicopathologic features of benign Brenner tumors of the ovary*

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