Mixed odontogenic tumors: An analysis of 23 new cases

Abstract

The ameloblastic fibroma, ameloblastic fibrodentinoma, and ameloblastic fibro‐odontoma are mixed odontogenic tumors that are considered to arise from both epithelial and mesenchymal elements of the tooth germ. This article presents the clinical and histopathologic characteristics of 23 new cases. The patients' ages ranged from 3 to 19 years (median 9). Most tumors were asymptomatic and were associated with an unerupted tooth or teeth. All patients were treated with simple enucleation of the tumor. We found that histologically these lesions comprise a spectrum. Some were probably benign odontogenic tumors (neoplasms) and others were odontomas undergoing maturation (hamartomas); however, in any given case we were, on histologic grounds, unable to differentiate the two. The majority, if not all, of our cases were nonaggressive with little or no tendency to recur, whereas some reported cases have exhibited local aggressiveness and recurrence, suggestive of neoplasia. In our opinion, it is clinically important to distinguish the mixed odontogenic tumors from ameloblastoma since the mixed tumors, found mostly in children, are relatively benign when compared to ameloblastoma, which is found in all age groups (usually adults). The usually innocuous behavior of these lesions does not justify aggressive treatment initially, and simple enucleation should be appropriate in most cases.

Clinical and Radiological Profile of Ameloblastic Fibro-Odontoma: an Update on an Uncommon Odontogenic Tumor Based on a Critical Analysis of 114 Cases

“…However, at the present time, there is no unequivocal way of distinguishing between a neoplastic AFO and a developing odontoma [7,8,37,89,93].…”

Ameloblastic fibro-odontoma arising in the mandible: three case reports

“…In some radiographic reports of ameloblastic fibro-odontoma, the lesion is characterized by a radiolucent appearance with well-defined radiopaque components, which are generally located at the center of the lesion [4][5][6][7][8][9]. The center of the tumor generally consists of multiple radiopacities representing the odontoma [8].…”

“…Although some reports have included conventional radiographic images of ameloblastic fibro-odontoma [4][5][6][7][8][9], few studies have compared conventional radiographic and computed tomography (CT) images of ameloblastic fibro-odontoma.…”

Ameloblastik fibroma: İki olgu sunumu

“…Epitelyal komponenti ince dallanan kordlar ile bazofilik çekirdek ve az sitoplazma içeren odontojenik epitelin küçük hücre kümeleri olu turmaktad r. Stellat retikulumun santral bölgesinde daha büyük hücre kümeleri izlenebilir (7,12,13).…”