Mixed Neuroendocrine Carcinoma and Squamous Cell Carcinoma of the Colon: Case Report and Literature Review

Abstract

Neuroendocrine carcinoma (NEC) of the colon is very rare, and squamous cell carcinoma (SCC) of colon cancer is rare. We recently treated a patient with both NEC and SCC that initially presented as multiple unresectable liver and lung metastases. A 68-year-old Japanese man was referred to our hospital because of diarrhea with descending colon cancer obstruction. He underwent a left colectomy. Based on immunohistochemistry results, we diagnosed mixed NEC and SCC, the primary lesion location of which was probably the lung in the final pathologic examination. He began systemic palliative chemotherapy with CDDP and CPT-11. After 3 months of treatment, shown the progressive disease, we started CDDP and VP-16. The patient was not eligible for additional chemotherapy after 2 months.

Mixed neuroendocrine and squamous cell carcinoma of the colon: A case report and literature review

“…Munakata et al recently published a case report of mixed neuroendocrine carcinoma and squamous cell carcinoma of the lung that metastasized to the colon and liver, which was treated with six cycles of chemotherapy, but the patient was not eligible for additional chemotherapy after 2 months [12]. The authors suggest a possible common link between the pathogenesis and conclude future research is required to determine the pathogenesis of these synchronous tumors [12]. Our case alternatively reports primary colon cancer with no distant metastases at the time of diagnosis, but rather local lymph and tissue metastases which were excised.…”

Combined large cell neuroendocrine carcinoma and squamous cell carcinoma of the oropharynx: A collision course of tumors

“…Outside of the H&N, a small number of case reports in the literature describe combined LCNEC and SCC in the gastrointestinal tract, specifically in the colon and rectum 26–29 26 .…”

“…Outside of the H&N, a small number of case reports in the literature describe combined LCNEC and SCC in the gastrointestinal tract, specifically in the colon and rectum 26–29 26 . Conversely, Woischke et al present two cases of combined LCNEC and SCC of the colon with histologic and genetic evidence of local origin in the colon 27 .…”