Mixed Micellization of drug-excipients and its application to enhance the binding and encapsulation efficacy of ibuprofen in aqueous media

Counterion Association of Ionic Drugs with Sodium Tetradecyl Sulfate in the Aqueous Medium

“…As indicated in Table , the concentrations of CAC dropped as the concentration of DPC increased in the micellar medium. We previously reported that the CMC of DPC was 92.2 mmol L –1 and CPM was 66.8 mmol L –1 in water, , and that at lower concentrations of STS molecules, monomeric interactions between STS-DPC and STS-CPM were discovered, with the first break occurring. The CMC of STS was thought to be the second or most prominent break in the conductance graphs.…”

“…Therefore, it was chosen that the fitted value of N m was approximately equivalent to 1, and the absorbance data showed that one drug was bound to each micelle. Other studies have already reported on the variance of N m values. ,,,,,,, For instance, Caetano and Tabak used a relation similar to eq to analyze the absorbance data of the drugs trifluoperazine and chlorpromazine in aqueous cetyltrimethylammonium chloride solution, resulting in found values of N m in the variety of 0.90–1.14 for chlorpromazine and in the range of 1.00–1.12 for trifluoperazine. Pellosi et al reported values of N m around 1 for the four xanthenes dyes fluorescein, eosin Y, erythrosin B, and rose bengal B in an aqueous pluronic P-123 solution, however, they observed values of N m close to 2 in an aqueous cetyltrimethylammonium bromide solution.…”

“…Other studies have already reported on the variance of N m values. 13,14,19,28,29,32,40,41 For instance, Caetano and Tabak 45 Furthermore, the K b value was determined using the slope and intercept data from Figure 8. For DPC and CPM, the values of log K b were 2.232 and 2.837, respectively.…”

Comparative studies on the aggregate formation of synthesized zwitterionic gemini and monomeric surfactants in the presence of the amphiphilic antipsychotic drug chlorpromazine hydrochloride in aqueous solution: an experimental and theoretical approach

“…The values of b R and b have similarity in magnitude and the same trend has been observed for the CPZ/ C 12 DmCB system (Tables 3 and 4) and also the undefined values of the interaction parameter (b R ) according to the Rubingh model for the CPZ/C 14 Ab system were obtained here (b values in Table 4) by applying this thermodynamic model. The values of cmc cal also show (Table 4) good similarity with the experimental values (Table 2) which have been calculated by using eqn (25) with the help of eqn ( 26) and (27).…”

“…20 In the pharmaceutical field, mixed micelles have been shown to enhance the absorption of various water-insoluble drugs in the human body, as mixed micelle systems have been used as effective drug carriers. [21][22][23][24][25] Most drugs commonly used as local anesthetics, antidepressants, sedatives, and antibiotics are amphiphilic, like conventional surfactants, and can form micellar aggregates in water with an aggregation number of 8-10. 26 The pharmacological activity of these drugs requires a concentration well below their cmcs, 27 which are measured in vitro with a negligible number of drug monomers in the aggregated units.…”