Mixed micelles of structurally related antidepressant drugs

Thermodynamics of Micellization of Surfactants of Low Aggregation Number: The Aggregation of Propranolol Hydrochloride

“…In our continuing investigations on the association characteristics and surface properties of a wide variety of drugs (1)(2)(3)(4)(5) we have investigated propranolol hydrochloride (I), which is the prototype of the beta-adrenergic blocking agents. It is a racemic compound, with only its 1-isomer having any adrenergic blocking activity.…”

Influence of Molecular Structure on the Ideality of Mixing in Micelles Formed in Binary Mixtures of Surface-Active Drugs

“…1 to 4 show the variation of the critical concentration with the composition of the mixed micelles as determined by this method. The lower curves (dotted) show the variation of the experimentally measured cc with the composition of the systems, which was fitted to equations of the form cc ϭ a͑ x 2 ͒ 2 ϩ b͑ x 2 ͒ ϩ c. [6] Fit parameters for the four systems are listed in Table 2. To quantify the nonideality of mixing in the mixed aggregates we have used the simplified approach proposed by Holland and Rubingh (14).…”

Conductometric and spectrofluorimetric characterization of the mixed micelles constituted by dodecyltrimethylammonium bromide and a tricyclic antidepressant drug in aqueous solution

“…The presence of this alkyl amine side chain on TCA molecules confers on them a "surfactant-like" behavior, which may be manifested in the formation of aggregates in aqueous solution. This aggregation behavior of TCA molecules in general [5,6], and of AMYTP in particular [7], has been previously investigated using conductivity experiments.…”