Mixed Lymphocyte-Platelet, Lymphocyte-Kidney Cell and Lymphocyte-Liver Cell Reactions in Rats

Nishihira, Tetsuro; Fujii, G

doi:10.1620/tjem.108.1

Cited by 7 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that rat whole liver tissue expresses very little Ia-like antigen (Hart & Fabre 1979) and there is evidence in the rat, as in the pig that the parenchymal cells themselves lack Ia-like antigens (Davies, unpublished data). Reports that rat liver cells stimulated proliferation of allogeneic lymphocytes may have been due to contamination by passenger lymphocytes (Nishihira & Fujii 1972). However, it was recently reported that rat liver cells were capable of stimulating lymphocytes in a system designed t o exclude passenger lymphocytes (Sakai et al 1978).…”

Section: Discussionmentioning

confidence: 99%

“…these are skin cells (Cochrum et al 1971, Levis & Miller 1972, Hirschberget al 1973, vascular endothelium (Hirschberg et al 1974 and spermatozoa (Levis et al 1974(Levis et al , 1975; in the dog, vascular endothelium (Vetto & Burger 1972) and kidney cells (Lifton et al 1977); in the rat, skin cells , kidney cells (Main et al 1975, Mashimo et al 1976), heart cells (Sakai et al 1977) and liver cells (Nishihira & Fujii 1972, Sakai et al 1978; and in the pig, kidney cells (Pawelec 1977) and liver cells .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Stimulation of Lymphocyte Proliferation by Non‐Lymphoid Porcine Tissue Cells

Pawelec

et al. 1979

Tissue Antigens

View full text Add to dashboard Cite

Cultured porcine non‐lymphoid cells, characterized by biochemical and morphological criteria, were derived from different tissues of individuals typed by serological and mixed lymphocyte culture methods for gene products of the major histocompatibility complex. These cultured cells have been used as stimulators in mixed lymphocyte‐tissue cell cultures in order to investigate (1) the magnitude, kinetics and dose‐dependence of lymphocyte transformation caused by tissue cells compared with that caused by lymphocytes as stimulators; (2) the relationship between the expression of serologically detected Ia‐like antigens by tissue cells and their ability to cause lymphocyte transformation; (3) the genetic control of stimulation by tissue cells and by lymphocytes and (4) the expression and genetic control of lymphocyte stimulatory properties restricted to tissue cells and absent from lymphocytes. It has been shown that some but not all kinds of tissue cells can stimulate allogeneic lymphocytes strongly and that the characteristics of such stimulation are similar to those observed in mixed lymphocyte cultures. Strong stimulation by tissue cells does not always correlate with the expression of serologically detectable Ia‐like antigens, but appears to be controlled by the major histocompatibility complex. There is evidence that certain tissue cells possess lymphocyte stimulatory properties not shared by lymphocytes. Preliminary data suggest that such tissue cell specific stimulation is not controlled by the major histocompatibility complex, though more detailed genetic analysis is required.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Stimulation of Lymphocyte Proliferation by Non‐Lymphoid Porcine Tissue Cells

Pawelec

et al. 1979

Tissue Antigens

View full text Add to dashboard Cite

show abstract

“…One way mixed lymphocyte reaction (MLR) was performed with peripheral blood lymphocytes (PBL) obtained from axillary arteries (Nishihira and Fujii 1972). Stimulating cells of F1 hybrid PBL were irradiated with 1,000 rads electron beam and those of LJ cells with 8,000 rads.…”

Section: -Azaguanine Resistant L Cells Derived From C3h/he Mouse (H-mentioning

confidence: 99%

Prolonged survival time of allogeneic skin grafts in host pretreated with somatic cell hybrids and prednisolone.

Nishihira

Ishii

Kasai

et al. 1979

Tohoku J. Exp. Med.

Self Cite

View full text Add to dashboard Cite

The Mixed Kidney Cell – Lymphocyte Reaction in Rats

et al. 1976

View full text Add to dashboard Cite

Optimal conditions for obtaining the proliferative response in mixed kidney cell‐lymphocyte culture (MKLC) have been determined in rats. The addition of 2‐mercaptoethanol to the culture medium was essential for successful stimulation of lymphocytes by allogeneic kidney cells. Proliferative responses by standard MLC and MKLC were compared in rats with the same or a different Ag‐B locus. In most strain combinations, there was a significant correlation between MLC and MKLC reactions. However, the DA‐ACI combination, compatible at the Ag‐B locus, consistently showed negative MLC and positive MKLC reactions. This suggested the possibility that this technique allowed the expression of kidney specific antigens.

show abstract

Mixed Lymphocyte-Platelet, Lymphocyte-Kidney Cell and Lymphocyte-Liver Cell Reactions in Rats

Cited by 7 publications

References 2 publications

Stimulation of Lymphocyte Proliferation by Non‐Lymphoid Porcine Tissue Cells

Stimulation of Lymphocyte Proliferation by Non‐Lymphoid Porcine Tissue Cells

Prolonged survival time of allogeneic skin grafts in host pretreated with somatic cell hybrids and prednisolone.

The Mixed Kidney Cell – Lymphocyte Reaction in Rats

Contact Info

Product

Resources

About