Mixed lymphocyte cultures in rheumatoid arthritis.

Šťastný, Peter

doi:10.1172/jci108382

Cited by 300 publications

(150 citation statements)

References 29 publications

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“…HLA-Dw4 and Dw14 are increased among Caucasian subjects with RA, and Dw15 is increased among Japanese subjects with RA, while DwlO is absent among RA patients in both groups (39)(40)(41). In contrast, in another HLA-DR4-associated autoimmune dermatologic disease, pemphigus vulgaris, only the HLADw 10 subtype has been found to be associated with disease susceptibility, among an Ashkenazi Jewish patient population (15,16).…”

Section: Discussionmentioning

confidence: 91%

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

Kaneoka

Hsu

Takeda

et al. 1992

Arthritis & Rheumatism

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Objective. We have recently found that the presence of autoantibodies against the 70-kd polypeptide of U1 RNP (Ul-70-kd) is associated with HLA-DR4 and DR2. To further characterize this association, we performed a molecular genetic analysis of HLA-DR and DQ genes among patients with autoantibodies against Methods. The polymerase chain reaction (PCR), sequence-specific oligonucleotide hybridization, and U1-70-kd.

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Section: Discussionmentioning

confidence: 91%

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

Kaneoka

Hsu

Takeda

et al. 1992

Arthritis & Rheumatism

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“…In the light of the present report, the findings by Ferreira and Nussenzweig (24) of a control of the serum levels of CS by the H-2 system acquire In any event, it is probably significant that C3 variants in humans appear to be associated with several diseases (reviewed in ref. 14), some of which (rheumatoid arthritis and leprosy) have known associations with the HLA system (25,26), while others are associated with viral infections (hepatitis and influenza). Susceptibility to such infections has been suspected of being determined by MHR-linked immune response (Ir) genes.…”

Section: Discussionmentioning

confidence: 99%

Murine complement component 3: genetic variation and linkage to H-2.

Silva¹,

Hoecker²,

Day³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

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Two electrophoretic variants of murine complement component 3 (C3) were detected by using high-voltage electrophoresis of fresh mouse serum in agarose gels. Most of the inbred strains tested were homozygous for the S allele (for the slow-migrating variant); only four out of 46 strains had the alternative F allele (fast variant). Pen-bred Swiss-Webster animals belonged to one of three phenotypes-S. F, or SF-and the genes responsible for this variation segregated in a strictly Mendelian manner. In three such crosses, with 52 offspring, C3 segregated with H-2 in 46 instances, corresponding to a recombination frequency of -0.12.

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“…The association of RA with HLA-Dw4 was first reported by Stastny in 1976. 6 The development of higher resolution HLA-DRB1 genotyping led to the demonstration that different HLA-DR4 alleles are not equally associated with RA.…”

Section: The Shared Epitope (Se) Hypothesismentioning

confidence: 99%

A review of the MHC genetics of rheumatoid arthritis

et al. 2004

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Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.

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Mixed lymphocyte cultures in rheumatoid arthritis.

Cited by 300 publications

References 29 publications

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

Molecular Genetic Analysis of HLA—DR and HLA—DQ Genes Among Anti—U1‐70‐kd Autoantibody Positive Connective Tissue Disease Patients

Murine complement component 3: genetic variation and linkage to H-2.

A review of the MHC genetics of rheumatoid arthritis

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