Mixed-Lymphocyte-Culture and Skin-Graft Data in Unrelated Hl-a Identical Individuals

Koch, C; Eysvoogel, V. P.; Frederiks, Edith; Rood, Jon J. van

doi:10.1016/s0140-6736(71)92358-0

Cited by 23 publications

(5 citation statements)

References 5 publications

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“…In man increasing evidence indicates the existence of an MLC locus outside of the HL-A region (1). These findings may be of considerable importance when unrelated HL-A identical donor-recipient pairs are used in tissue grafting experiments (16). As previously demonstrated in man and dogs, H typing correlates well with MLC reactivity in sibships (17,18).…”

Section: Discussionsupporting

confidence: 70%

Consequent Intrafamilial Immunization for Dl-a Haplotyping in Canines

Does

Rood

Walker

et al. 1973

The Journal of Experimental Medicine

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A procedure of intrafamilial immunization is described for production of antisera recognizing DL-A haplotypes. In a colony consisting of 1 sire, 6 bitches, and 67 offspring all haplotypes could be accurately allocated. In the colony the observed reaction frequencies of the antisera are in agreement with mendelian codominant inheritance. Mixed lymphocyte culture tests confirmed the accuracy of the serologic typing and the presence of homozygous individuals within the colony. Further evidence is presented supporting the presence of two or more subloci within the DL-A system. Colonies of canines such as the one described should provide a sensitive system for evaluating interaction between serologic DL-A typing, MLC reactivity, and immune response genetics in a nonrodent species which is not highly inbred.

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Section: Discussionsupporting

confidence: 70%

Consequent Intrafamilial Immunization for Dl-a Haplotyping in Canines

Does

Rood

Walker

et al. 1973

The Journal of Experimental Medicine

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“…Further detailed studies will be required to clarify this point with particular regard to the possible relationship of HLA-DR antibodies to the beneficial effects of blood tranfusions before transplantation. The results of this study may also be of relevance to earlier reports on the influence of HLA-D compatibilities upon the survival of skin (16,30,31) and bone marrow (32) In the murine species, where the H-2 complex bears so many similarities to HLA, the I subregion (Ia and Ic), which has the major MLC-stimulating power, is also the source of the determinants which govern the serologically detectable Ia products (33). It is interesting, in this regard, that skin graft incompatibilities at the murine Ia subregion result in acute rejection and formation of anti-Ia antibodies as well as effector T-lymphocytes detectable by the cell-mediated lympholysis technique (34).…”

Section: Discussionsupporting

confidence: 76%

Role of Ia-Like Products of the Main Histocompatibility Complex in Conditioning Skin Allograft Survival in Man

Dausset¹,

Contu²,

Legrand³

et al. 1979

J. Clin. Invest.

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“…There have been many reports that the skin graft survival is significantly correlated with HLA-A and -B antigen compatibility (7,(9)(10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

“…HLA antigens (7,(9)(10)(11)(12)(13) and ABO blood group antigens (14) exert an influence on the survival time of homografts in human subjects. There have been some reports that HLA-compatible grafts were applied to burned patients in order to prolong survival time (7,10).…”

Section: Introductionmentioning

confidence: 99%

Influence of Histocompatibility Antigens on Skin Homograft Survival in an Extensively Burned Patient

Higuchi

Sei

Takiuchi

1981

The Journal of Dermatology

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Thirty‐eight donors were selected from 312 volunteers to be as nearly compatible as possible with the patient's HLA‐A and ‐B antigens. In addition to HLA‐A and ‐B, MLC test was performed between the patient and all but one of the 38 donors (Donor No. 35), and all 38 homografts were applied to the patient at once. The mean survival time of HLA‐A and ‐B‐identical grafts was better than two haplotype‐mismatched grafts. There were no clear differences between 0 and 1, or 1 and 2 haplotype‐mismatched grafts. No definite differences in the survival number at 21 days was observed between HLA‐A and ‐B‐identical grafts and 1 haplotype‐mismatched grafts. However, a significant difference was detected between (0+1) mismatched grafts and 2 mismatched grafts. We were not able to detect any effects of ABO blood antigens or sex on graft survival.

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Mixed-Lymphocyte-Culture and Skin-Graft Data in Unrelated Hl-a Identical Individuals

Cited by 23 publications

References 5 publications

Consequent Intrafamilial Immunization for Dl-a Haplotyping in Canines

Consequent Intrafamilial Immunization for Dl-a Haplotyping in Canines

Role of Ia-Like Products of the Main Histocompatibility Complex in Conditioning Skin Allograft Survival in Man

Influence of Histocompatibility Antigens on Skin Homograft Survival in an Extensively Burned Patient

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