Mixed ligand Cu(II) complexes of an unsymmetrical Schiff base ligand and N-donor heterocyclic co-ligands: Investigation of the effect of co-ligand on the antibacterial properties

Albobaledi, Zeinab; Esfahani, Maryam Hasanzadeh; Behzad, Mahdi; Abbasi, Alireza

doi:10.1016/j.ica.2019.119185

Cited by 22 publications

(7 citation statements)

References 37 publications

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“…The value of (τ) is almost between the two limiting values but it is slightly closer to that of SBP and hence, the geometry could be described as distorted SBP [ 22 ]. The obtained bond lengths, bond angles, and the (τ) value is in the same range of previously reported similar complexes [ [23] , [24] ]. The weak hydrogen bonds N-H…O, table 3 , together with the CH-π and π - π stacking interactions stabilize the entire 3D Network structure ( figure 3 ).…”

Section: Resultssupporting

confidence: 88%

Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore modeling studies on the main proteases of SARS-CoV-2 virus (COVID-19 disease)

et al. 2022

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Section: Resultssupporting

confidence: 88%

Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore modeling studies on the main proteases of SARS-CoV-2 virus (COVID-19 disease)

et al. 2022

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“…These data are similar to previously published complexes with the same scaffold. [16][17][18] Besides, there are two moderate and two weak hydrogen bonds (H. bonds) (N4-H4A … O5, N4-H4B … O4, and C11-H11 … O4, C15-H15A … O6 with distances D … A of 3.198, 3.220, and 3.496, 3.411 Å, respectively), together with one relatively weak halogen bond of Br1 … O7, 3.263 Å, between perchlorate ions and complexes, stabilizing the 3D crystal structure.…”

Section: Crystallographic Data Collection and Determination Of The St...mentioning

confidence: 99%

“…We have previously synthesized a series of mixedligand Schiff base complexes [16][17][18] and have studied their antibacterial properties. Those complexes had the general formula [Cu(SB)(L')]ClO 4 , in which the SBs were unsymmetrical tridentate NN'O type Schiff base ligands and the L's were either pyridine or bipyridine/ phenanthroline derivatives.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of two new mixed‐ligand Cu(II) complexes of a tridentate NN'O type Schiff base ligand and N‐donor heterocyclic co‐ligands: In vitro anticancer assay, DNA/human leukemia/COVID‐19 molecular docking studies, and pharmacophore modeling

Ghasemi

Behzad

Khaleghian

et al. 2022

Applied Organom Chemis

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Two new mixed-ligand complexes with general formula [Cu(SB)(L')]ClO 4(1 and 2) were synthesized and characterized by different spectroscopic and analytical techniques including Fourier transform infrared (FT-IR) and UV-Vis spectroscopy and elemental analyses. The SB ligand is an unsymmetrical tridentate NN'O type Schiff base ligand that was derived from the condensation of 1,2-ethylenediamine and 5-bromo-2-hydroxy-3-nitrobenzaldehyde. The L' ligand is pyridine in (1) and 2,2 0 -dimethyl-4,4 0 -bithiazole (BTZ) in (2). Crystal structure of (2) was also obtained. The two complexes were used as anticancer agents against leukemia cancer cell line HL-60 and showed considerable anticancer activity. The anticancer activity of these complexes was comparable with the standard drug 5-fluorouracil (5-FU). Molecular docking and pharmacophore studies were also performed on DNA (PDB:1BNA) and leukemia inhibitor factor (LIF) (PDB:1EMR) to further investigate the anticancer and anti-COVID activity of these complexes. The molecular docking results against DNA revealed that (1) preferentially binds to the major groove of DNA receptor whereas (2) binds to the minor groove. Complex (2) performed better with 1EMR. The experimental and theoretical results showed good correlation. Molecular docking and pharmacophore studies were also applied to study the interactions between the synthesized complexes and SARS-CoV-2 virus receptor protein (PDB ID:6LU7). The results revealed that complex (2) had better interaction than (1), the free ligands (SB and BTZ), and the standard drug favipiravir.anticancer, COVID-19, mixed-ligand, molecular docking, unsymmetrical Schiff base CCDC number 2089608 contains the supplementary crystallographic data for complex (2). These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif (supporting information).

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“…recorded on SHIMADZU UV-1601 UV-visible spectrophotometer. 1 H-NMR (300 MHz) spectra were measured on Bruker Avance instrument in d6-DMSO and TMS as internal standard. Reaction progress was monitored by thin layer chromatography (TLC).…”

Section: Crystengcomm Accepted Manuscriptmentioning

confidence: 99%

Interplay of weak noncovalent interactions in alkoxybenzylidene derivatives of benzohydrazide and acetohydrazide: a combined experimental and theoretical investigation and lipoxygenase inhibition (LOX) studies

et al. 2021

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Mixed ligand Cu(II) complexes of an unsymmetrical Schiff base ligand and N-donor heterocyclic co-ligands: Investigation of the effect of co-ligand on the antibacterial properties

Cited by 22 publications

References 37 publications

Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore modeling studies on the main proteases of SARS-CoV-2 virus (COVID-19 disease)

Synthesis and crystal structures of new mixed-ligand schiff base complexes containing N-donor heterocyclic co-ligands: Molecular docking and pharmacophore modeling studies on the main proteases of SARS-CoV-2 virus (COVID-19 disease)

Synthesis and characterization of two new mixed‐ligand Cu(II) complexes of a tridentate NN'O type Schiff base ligand and N‐donor heterocyclic co‐ligands: In vitro anticancer assay, DNA/human leukemia/COVID‐19 molecular docking studies, and pharmacophore modeling

Interplay of weak noncovalent interactions in alkoxybenzylidene derivatives of benzohydrazide and acetohydrazide: a combined experimental and theoretical investigation and lipoxygenase inhibition (LOX) studies

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