Mixed ligand complexes with 2-piperidine-carboxylic acid as primary ligand and ethylene diamine, 2,2′-bipyridyl, 1,10-phenanthroline and 2(2′-pyridyl)quinoxaline as secondary ligands: preparation, characterization and biological activity

Abstract

Synthesis procedures are described for the new stable mixed ligand complexes, [Pd(Hpa)(pa)]Cl, [Pd(pa)(H 2 O) 2 ]Cl, [Pd(pa)(en)]Cl, [Pd(pa)(bpy)]Cl, [Pd(pa)(phen)Cl], [Pd(pa)(pyq)Cl], cis-[MoO 2 (pa) 2 ], [Ag(pa)(bpy)], [Ag(pa)(pyq)], trans-[UO 2 (pa)(pyq)](BPh 4 ) and [ReO (PPh 3 )(pa) 2 ]Cl (Hpa = 2-piperidine-carboxylic acid, en = ethylene diamine, bpy = 2,2¢-bipyridyl, phen = 1,10-phenanthroline, pyq = 2(2¢-pyridyl)quinoxaline). Their elemental analyses, conductance, thermal measurements, Raman, IR, electronic, 1 H-n.m.r. and mass spectra have been measured and discussed. 2-Piperidine-carboxylic acid and its palladium complexes have been tested as growth inhibitors against Ehrlich ascites tumour cells (EAC) in Swiss albino mice.

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

“…[21][22][23][24][25] A good number of mixed ligand complexes containing 1,10-phenanthroline as a ligand are identied as potential chemotherapeutic agents and have received much attention in the eld of medicine. [26][27][28][29] In view of the promising biological activities of these scaffolds our main intention was to explore whether the incorporation of these important scaffolds in one complex would result in potentiation of activities and therefore would give a new strategy for the development of chemotherapeutic agents. Finding rare instances of literature about the tryptamine based Schiff base ligands and their mixed ligand complexes with 1,10phenenthroline, bearing an indole ring pendent, we report the synthesis, characterization and antifungal activity of the ligand and its metal complexes.…”

Antineoplastic Activity of New Transition Metal Complexes of 6‐Methylpyridine‐2‐carbaldehyde‐N(4)‐ethylthiosemicarbazone: X‐Ray Crystal Structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl]

“…Also, the far IR and Raman spectra show new bands near 325 and 300 cm −1 can be assigned to v (M-S) and v (M-Cl), respectively [9, 10]. …”

Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2′-Bipyridyl

“…Also, the spectrum of [Ag(bpy)(Hdahmp)] + shows bands at 467, 382, and 277 nm; the latter two may arise from charge transfer of the type ligand ( π ) → b 1g (Ag + ) and ligand ( σ ) → b 1g (Ag + ), respectively, in a typically distorted square planar environment around the metal ion [4, 28, 29]. …”

“…The elemental analyses of the isolated complexes agree with the assigned formula. The conductivities (Λ M ) in DMF at room temperature showed the electrolytic character of these complexes [ 4 , 16 ].…”

“…Over the past years, a renewed interest in Pd(II) complexes as potential anticancer agents has developed. Though a number of interesting Pd(II) targets have been investigated [ 4 – 7 ], the biological utility of such agents continues to be questioned, this may be due to the poor solubility of common Pd(II) complexes under physiologic conditions. Many studies, including nucleic and amino acid derivatives, showed that 2-mercaptopyrimidine and 2-mercapto-4-aminopyrimidine are able to inhibit the synthesis of t -RNA [ 8 ].…”