Mixed ligand complexes of cadmium(II) and copper(II) dithiocarbazate: Synthesis, spectral characterization, X-ray crystal structure

Takjoo, Reza; Centore, Roberto; Hayatolgheibi, S. Samaneh

doi:10.1016/j.ica.2017.11.043

Cited by 19 publications

(3 citation statements)

References 42 publications

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“…The electronic spectra data of H1 and 2 are tabulated in Table 1. H1 exhibits 2 spectral bands at 262 and 380 nm, which can be assigned to the (*) aromatic ring of the dithiocarbazate and 5-fluoroindole moiety, and (n*) of the carbonyl (C=O), thione (C=S) and azomethine (C=N) groups respectively (Table 1) [12,25]. On the other hand, the spectrum of the cadmium complex showed only an intra-ligand transition with the n* band experiencing a shift to longer wavelength (265 nm).…”

Section: Spectroscopic and Physical Characterization Of Complexmentioning

confidence: 99%

Cadmium(II) Schiff base Complex Containing 5-Fluoroisatin Moiety: Synthesis, Characterization, Antibacterial Activity and Structural Studies

Manan

Cordes

2022

Trends Sci

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The Schiff base ligand, HSB5FISA (H1), obtained by the condensation of S-benzyldithiocarbazate with 5-fluoroisatin, has been employed to synthesize a new cadmium(II) complex, Cd(SB5FISA)2 (2) (SB5FISA = monoanionic form of H1). The complex has been characterized by elemental analysis, molar conductivity, magnetic susceptibility, inductively coupled plasma atomic emission spectroscopy (ICP-AES), Fourier-transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectroscopy (UV-Vis). The crystallographic study of Cd(SB5FISA)2×2DMSO (2a) (DMSO = dimethyl sulfoxide) was conducted using single-crystal X-ray diffraction. The crystal structure of 2a confirmed the presence of 6-coordinated cadmium in a distorted octahedral environment. Ligand H1 behaves in a tridentate monoanionic fashion, coordinating to a cadmium(II) metal centre through the thiolate sulfur, azomethine nitrogen and carbonyl oxygen. The antibacterial activity of both H1 and 2 was examined against 4 different bacterial strains using the disc diffusion method. Complex 2 showed significant inhibitory effect against Bacillus subtilis with an inhibition zone of 14 mm, comparable to the standard antibiotic streptomycin. HIGHLIGHTS Cd(II) complex of 5-fluoroisatin Schiff base was synthesized Structural studies of compound determined via single crystal X-ray diffraction Compound exhibited significant antibacterial activity towards Bacillus subtilis GRAPHICAL ABSTRACT

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Section: Spectroscopic and Physical Characterization Of Complexmentioning

confidence: 99%

Cadmium(II) Schiff base Complex Containing 5-Fluoroisatin Moiety: Synthesis, Characterization, Antibacterial Activity and Structural Studies

Manan

Cordes

2022

Trends Sci

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“…They have different donor atoms that can coordinate with metals and form stable chelates. These compounds can also be modified in their -R groups, leading to different possibilities and coordination sites, such as bi, tri, or polydentate forms, in addition to forming complexes with different geometries ( Li et al, 2012 ; Lima et al, 2018 ; Takjoo et al, 2018 ; Yekke-Ghasemi et al, 2018 ; Yusof et al, 2019 ; Boshaala et al, 2021 ). Furthermore, the biological action of free dithiocarbazates can be potentiated or suppressed (protective effect) after complexing with different metal ions ( Cavalcante et al, 2019 ; Sohtun et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Dithiocarbazate ligands and their Ni(II) complexes with potential biological activity: Structural, antitumor and molecular docking study

Cavalcante

Mota

Oliveira

et al. 2023

Front. Mol. Biosci.

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In the search for new metal complexes with antitumor potential, two dithiocarbazate ligands derived from 1,1,1-trifluoro-2,4-pentanedione (H2L1) and (H2L2) and four Ni(II) complexes, [Ni(L1)PPh3] (1), [Ni(L1)Py] (2), [Ni(L2)PPh3] (3), and [Ni(L2)Py] (4), were successfully synthesized and investigated by physical-chemistry and spectroscopic methods. The crystal structure of the H2L1 and the Ni(II) complexes has been elucidated by single-crystal X-ray diffraction. The obtained structure from H2L1 confirms the cyclization reaction and formation of the pyrazoline derivative. The results showed square planar geometry to the metal centers, in which dithiocarbazates coordinated by the ONS donor system and a triphenylphosphine or pyridine molecule complete the coordination sphere. Hirshfeld surface analysis by dnorm function was investigated and showed π–π stacking interactions upon the molecular packing of H2L1 and non-classical hydrogen bonds for all compounds. Fingerprint plots showed the main interactions attributed to H⋅H C⋅H, O⋅H, Br⋅H, and F⋅H, with contacts contributing between 1.9% and 38.2%. The mass spectrometry data indicated the presence of molecular ions [M + H]+ and characteristic fragmentations of the compounds, which indicated the same behavior of the compounds in solution and solid state. Molecular docking simulations were studied to evaluate the properties and interactions of the free dithiocarbazates and their Ni(II) complexes with selected proteins and DNA. These results were supported by in vitro cytotoxicity assays against four cancer cell lines, showing that the synthesized metal complexes display promising biological activity.

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“…Development of novel copper coordination compounds with antitumor activity is a promising and relevant area of medical chemistry [24][25][26][27]. A number of copper/Disulfiram-based drug combinations are in recruiting clinical trials as inexpensive and highly effective antitumor agents for metastatic breast cancer therapy and as diagnostic tools [28].…”

Section: Introductionmentioning

confidence: 99%

Copper Coordination Compounds as Biologically Active Agents

Krasnovskaya

Naumov

Guk

et al. 2020

IJMS

121

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Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. 64Cu-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer’s disease amyloid-β (Aβ). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.

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Mixed ligand complexes of cadmium(II) and copper(II) dithiocarbazate: Synthesis, spectral characterization, X-ray crystal structure

Cited by 19 publications

References 42 publications

Cadmium(II) Schiff base Complex Containing 5-Fluoroisatin Moiety: Synthesis, Characterization, Antibacterial Activity and Structural Studies

Cadmium(II) Schiff base Complex Containing 5-Fluoroisatin Moiety: Synthesis, Characterization, Antibacterial Activity and Structural Studies

Dithiocarbazate ligands and their Ni(II) complexes with potential biological activity: Structural, antitumor and molecular docking study

Copper Coordination Compounds as Biologically Active Agents

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