Mixed ligand complex via zinc(II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of antihypertensive agent

Bakale, Raghavendra P.; Naik, Ganesh N.; Mangannavar, Chandrashekhar V.; Muchchandi, Iranna S.; Shcherbakov, I. N.; Frampton, Chris; Gudasi, Kalagouda B.

doi:10.1016/j.ejmech.2013.11.037

Cited by 71 publications

(41 citation statements)

References 16 publications

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“…For a long time, the coordination chemistry of hydrazone ligands and their coordination compounds has attracted an extensive attention. This is due to their easy synthetic methods and diverse applications as, for example, anti‐microbial, anti‐tumour, anti‐tubercular and anti‐hypertensive agents. Indeed, heterocyclic hydrazones have interesting coordinating behaviour in addition to their broad applications in biological, analytical and various other fields …”

Section: Introductionmentioning

confidence: 99%

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Khalil

Kishk

EL-Mekkawi

et al. 2019

Applied Organom Chemis

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A new dual‐functional Cu(II) complex and its nanohybrid form encapsulated into NaY zeolite cavities were synthesized. The synthesized compounds were characterized using elemental analyses, X‐ray fluorescence, infrared, 1H NMR, electronic, electron spin resonance and mass spectra, powder X‐ray diffraction, surface area and transmission electron microscopy in addition to conductivity and magnetic susceptibility measurements. The encapsulated Cu(II) complex was catalytically tested for degradation of industrial wastewater. The decolorization and mineralization results indicate that the Cu(II) complex encapsulated into zeolite host is an effective heterogeneous catalyst for real industrial wastewater remediation. In addition, both free and encapsulated Cu(II) complexes were tested as anti‐microbial and anti‐tumour agents. The results show that the Cu(II) complex encapsulated into zeolite has a high activity (IC50 = 14.4 μg ml−1). The results of in vivo toxicity experiments indicate that the Cu(II) complex encapsulated into zeolite is a less toxic biocompatible material (LD50 = 1245 mg kg−1). The catalytic properties, cytotoxicity and toxicity of the new nanohybrid Cu(II) complex encapsulated into zeolite make it a promising eco‐friendly and biocompatible material for water remediation and biomedical applications.

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Section: Introductionmentioning

confidence: 99%

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Khalil

Kishk

EL-Mekkawi

et al. 2019

Applied Organom Chemis

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“…Mass spectra were recorded with the EI technique at 70 eV using an MS-5988 GS-MS Hewlett-Packard instrument at the Microanalytical Centre, Cairo University. 1 H NMR spectra were recorded using a 300 MHz Varian-Oxford Mercury. The solvent used was deuterated dimethylsulfoxide (DMSO-d 6 ) and the spectra extended from 0 to 15 ppm.…”

Section: Instrumentationmentioning

confidence: 99%

“…[1][2][3][4] Positively charged metal centre combined with heteroaromatic periphery forms well-defined geometries, which facilitate the interaction with biomolecules and transport across membranes in biological systems. [5,6] Thiosemicarbazone heterocyclic compounds and their metal complexes have attracted considerable attention due to their coordination chemistry and broad range of pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied

Zayed

Fahim

et al. 2017

Applied Organom Chemis

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Novel Schiff base [N′,N′″-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(benzohydrazide)] was formed by the condensation reaction of benzohydrazide with 2,2′-(ethane-1,2-diylbis(oxy))dibenzaldehyde. Its reaction with various metal ions was studied and the structures of the new products were characterized using common analytical and spectroscopic methods. All the metal complexes have pronounced anticancer activities. The antimicrobial activities against Gram-negative and Gram-positive bacteria were investigated.

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“…They are widely used in different areas, not only because of their facile synthesis, but also for potential biological, catalytic, and industrial applications [2,3]. Many recent reports show that they are good candidates for the development of new drugs as well as their usage in other biochemical processes like enzyme inhibition, or the simulation of antimicrobial, anti-cancer, anti-malarial activities [4,5].…”

Section: Introductionmentioning

confidence: 99%

cis-Dioxido-molybdenum(VI) complexes of tridentate ONO hydrazone Schiff base: Synthesis, characterization, X-ray crystal structure, DFT calculation and catalytic activity

Ebrahimipour

Khabazadeh

Castro

et al. 2015

Inorganica Chimica Acta

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C NMR and electronic spectra. The structure of complexes has been accomplished by single crystal X-ray diffraction. All experimental results confirmed that both complexes have an octahedral geometry around the Mo(VI) central atom, which is coordinated by the donor atoms of the dianionic hydrazone ligand, two oxido groups and oxygen/nitrogen atoms of solvent molecules. Computational studies were also performed using DFT calculations at B3LYP/DGDZVP level of theory. Furthermore, their catalytic activities were investigated on the electrophilic reaction of indole with aldehydes in molten tetrabutyl ammonium bromide (TBAB) to obtain bis(indolyl)methane derivatives.

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Mixed ligand complex via zinc(II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of antihypertensive agent

Cited by 71 publications

References 16 publications

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied

cis-Dioxido-molybdenum(VI) complexes of tridentate ONO hydrazone Schiff base: Synthesis, characterization, X-ray crystal structure, DFT calculation and catalytic activity

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Mixed ligand complex via zinc(II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of antihypertensive agent

Cited by 71 publications

References 16 publications

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

New less toxic zeolite‐encapsulated Cu(II) complex nanomaterial for dual applications in biomedical field and wastewater remediation

Synthesis of novel macrocyclic Schiff's‐base and its complexes having N2O2 group of donor atoms. Characterization and anticancer screening are studied

cis-Dioxido-molybdenum(VI) complexes of tridentate ONO hydrazone Schiff base: Synthesis, characterization, X-ray crystal structure, DFT calculation and catalytic activity

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Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied