Abstract:Pure chick kidney glomeruli and proximal tubular fragments have been isolated by graded sieving through nylon screens. Electron micrographs revealed that, in distinct contrast to proximal epithelial cells, the glomerular epithelial and endothelial cells are essentially devoid of mitochondria. Glomeruli as well as proximal tubular fragments contain the 1 alpha- and 24R-hydroxylases of 25-hydroxycholecalciferol. The level of 1 alpha-hydroxylase activity was the same in both segments of the nephron. However, the … Show more
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