Mixed-function oxidase activity in seabirds and its relationship to oil pollution

Peakall, David B.; Jeffrey, Deborah A.; Boersma, Dora C.

doi:10.1016/0742-8413(87)90059-4

Cited by 21 publications

(9 citation statements)

References 13 publications

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“…Numerous laboratory studies have documented the relationship between exposure to petroleum and cytochrome P450 induction. Activity of EROD was induced in adult Atlantic puffins ( Fratercula arctica ) after a single dose of Prudhoe Bay crude oil [36]. Hepatic naphthalene‐metabolizing activities of mallard ducks increased almost four times after exposure to food dosed with South Louisiana crude oil [37].…”

Section: Discussionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons, aliphatic hydrocarbons, trace elements, and monooxygenase activity in birds nesting on the North Platte River, Casper, Wyoming, USA

Custer

Dickerson

et al. 2001

Enviro Toxic and Chemistry

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Tree swallow (Tachycineta bicolor) and house wren (Troglodytes aedon) eggs and chicks were collected near a refinery site on the North Platte River, Casper. Wyoming, USA and at a reference site 10 km upstream. Total polycyclic aromatic hydrocarbon (PAH) concentrations in swallow and wren chicks were higher at the refinery site than at the reference site. Polycyclic aromatic hydrocarbon concentrations in sediment and chick dietary samples were consistent with these findings. The general lack of methylated PAHs in sediment, diet, and bird carcasses suggested that the PAHs were derived from combustion and not from petroleum. The predominance of odd-numbered aliphatic hydrocarbons and the low ratios (< or =0.25) of pristane:n-C17 and phytane:n-C18 in chick and diet samples also suggested that swallow and wren chicks were not being chronically exposed to petroleum. Mean ethoxyresorufin-O-dealkylase and benzyloxyresorufin-O-dealkylase activities in tree swallow livers averaged nine times higher at the refinery site than at the reference site and were probably induced by exposure to PAHs. Trace element concentrations in eggs and livers of swallows and wrens were similar or greater at the reference site than at the refinery site. Selenium, strontium, and boron concentrations were elevated in eggs and livers of swallows and wrens at both the refinery and reference sites.

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Section: Discussionmentioning

confidence: 99%

Polycyclic aromatic hydrocarbons, aliphatic hydrocarbons, trace elements, and monooxygenase activity in birds nesting on the North Platte River, Casper, Wyoming, USA

Custer

Dickerson

et al. 2001

Enviro Toxic and Chemistry

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“…Under captive conditions, the relationship between exposure to PAH-rich petroleum hydrocarbons and induction of the cytochrome P450-[A] system has been documented in a variety of nondomesticated avian species: Atlantic puffins (Fratercula artica) (Peakall et al, 1987), mallard ducks (Anas platyrhynchos) (Gorsline and Holmes, 1981), and European starlings (Sturnus vulgaris) (Trust et al, 1994). Peakall et al (1989) found single doses of Prudoe Bay crude oil caused induction of EROD activity in herring gulls and concluded that this hepatic mixed function oxidase activity was a sensitive, but short-lived (<72 h), biological indicator of recent and possibly continuous exposure to oil and PAHs.…”

Section: Origin Of the Exposures And Nature Of The Genotoxinsmentioning

confidence: 99%

DNA Strand Length and EROD Activity in Relation to Two Screening Measures of Genotoxic Exposure in Great Lakes Herring Gulls

et al. 2005

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We collected tissues from herring gulls (Larus argentatus) nesting within and outside of the Great Lakes basin. Genotoxin exposure was assessed as fluorescent aromatic compounds (FACs) in bile and SOS Chromotest-inducing activity in muscle extracts. We determined whether these exposures were associated with decreased erythrocyte DNA strand length and/or induction of hepatic ethoxyresorufin-O-deethylase (EROD) activity. FACs were detected in all bile samples. Most muscle extracts produced a positive or marginal SOS response in the presence of S9. SOS induction potentials were strongly associated with dietary trophic level. The median molecular length of DNA isolated from erythrocytes for 14 of 17 adult and 10 of 11 prefledgling collections was reduced compared to the modal class for their respective age group suggesting widespread DNA damage. DNA damage was greatest in gulls from Saginaw Bay, Lake Huron. Median EROD activity in both adults and prefledglings from remote locations was significantly lower than that of gulls from the lower Great Lakes and was not associated with concentrations of benzo[a]pyrene (B[a]P)-like FACs. Our results indicate Great Lakes herring gulls were exposed to genotoxins and Ah-receptor activating agents in biologically significant concentrations in the early 1990s. These agents appear to be persistent bioaccumulative compounds and/or their metabolites.

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“…One study (Riviere et al 1978) reported increased hepatic P‐450 and UDP‐GT activity in adult Japanese quail dosed with a PCB mixture (Phenochlor). Baseline hepatic UDP‐GT activity in galliform birds is considerably lower than in mammals in direct comparisons (Short et al 1988; McCleary et al 2001) and appear to be even lower in several species of fish‐eating birds than in galliforms (Peakall et al 1987). Hepatic UDP‐GT and EROD activity were correlated in individual liver samples from common terns in western Europe, but there were no significant differences in hepatic UDP‐GT activity between collection sites with a range of yolk sac PCBs of 6.4 times (Murk et al 1994).…”

Section: Studies Of Thyroid Function In Pcb‐exposed Birdsmentioning

confidence: 99%

Avian thyroid development in chemically contaminated environments: is there evidence of alterations in thyroid function and development?

McNabb

Fox²

2002

Evolution and Development

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Poor reproductive success, developmental abnormalities, and behavioral alterations in fish-eating birds in some Great Lakes areas have led to more than 35 years of toxicological studies and residue monitoring of herring gull (Larus argentatus) populations. Polyhalogenated aromatic hydrocarbons (PHAHs), especially polychlorinated biphenyls (PCBs), are widespread contaminants in the Great Lakes ecosystem. The introduction of regulations and elimination of point sources since the 1970s have resulted in decreased PHAHs in fish-eating bird eggs and tissues. PCB exposure is associated with thyroid disruption (hypothyroidism) in mammals, but much less is known of PCB effects on avian thyroid function. Our 1998-2000 studies of herring gulls from the Great Lakes show that both pipping embryos and prefledglings from highly contaminated sites have marked depletion of thyroid gland hormone stores compared with similarly aged gulls at the reference sites. However, organismal hypothyroidism was not apparent in many embryo and chick collections where severe depletion of thyroid gland hormone was observed. Adults, sampled at two high PCB sites and a low PCB site in the Great Lakes and the maritime reference colony in 2001, showed no differences in organismal thyroid status across sites, but gulls from the high sites had enlarged thyroid glands and depressed thyroid gland hormone stores. Here we discuss the evidence that ecological exposure to PHAHs are responsible for thyroid deficiencies in gulls and that during development these deficiencies lead to developmental abnormalities in young gulls from highly contaminated Great Lakes sites.

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Mixed-function oxidase activity in seabirds and its relationship to oil pollution

Cited by 21 publications

References 13 publications

Polycyclic aromatic hydrocarbons, aliphatic hydrocarbons, trace elements, and monooxygenase activity in birds nesting on the North Platte River, Casper, Wyoming, USA

Polycyclic aromatic hydrocarbons, aliphatic hydrocarbons, trace elements, and monooxygenase activity in birds nesting on the North Platte River, Casper, Wyoming, USA

DNA Strand Length and EROD Activity in Relation to Two Screening Measures of Genotoxic Exposure in Great Lakes Herring Gulls

Avian thyroid development in chemically contaminated environments: is there evidence of alterations in thyroid function and development?

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