Mixed form, diffusely scattered calcifications in breast cancer with apocrine features.

Kopans, Daniel B.; Nguyen, Phuong L.; Koerner, F C; White, G.; McCarthy, Kathleen A.; Hall, D A; Mrose, H E; Cardenosa, G; Pile-Spellman, Eliza

doi:10.1148/radiology.177.3.2173843

Cited by 19 publications

(6 citation statements)

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“…7,8 Groups of calcification that can reflect a benign view may be seen in apocrine tumors. 9 Mammographic imaging revealed peripheral macrocalcifications with central cystic areas that filled the whole left breast in our case.…”

Section: Medical Pathologysupporting

confidence: 48%

Diagnostic Pitfalls in Fine Needle Aspiration Cytology of Apocrine Carcinoma of the Breast: Case Report

Şahin¹,

Aktepe²,

Dılek³

et al. 2013

Turkiye Klinikleri J Med Sci

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576pocrine carcinoma of the breast is a rare, unique, and morphologically distinct type of invasive breast carcinoma. It is most frequent in the sixth and seventh decades.1 Main characteristics of apocrine carcinoma are unilaterality, multicentricity, low histological grade, lower positivity of estrogen (ER) and progesterone (PR) receptors.2 There is uncertainty about the diagnosis and prognosis of the apocrine carcinoma of the breast due to its rarity and the absence of standard definite diagnostic criteria in the histopathological examination.3 Apocrine changes of breast lesions can be seen in a spectrum from microscopic cysts to invasive carcinoma. Sclerosing adenosis, complex sclerosing lesions with apocrine foci, Diagnostic Pitfalls in Fine Needle Aspiration Cytology of Apocrine Carcinoma of the Breast:Case Report A AB BS ST TR RA AC CT T Apocrine carcinoma of the breast is a rare type of invasive breast cancer. It is most frequently seen in the postmenopausal period as a unilateral and multicentric mass. A 76-year-old female with a left breast mass for 12 years presented with left areolar retraction and discharge, and ulceration of the breast skin. A fine needle aspiration cytology (FNAC) of the breast mass showed three dimensional clusters of atypical cells with groups in a necrotic background. Those cells were apocrine-like and had hyperchromatic nuclei, cytoplasmic vacuoles and granular cytoplasms. The cytological result was reported as "suspicious for malignancy". The patient underwent simple mastectomy. Histological examination of the excised specimen revealed apocrine carcinoma. The differential diagnosis mainly includes benign lesions, such as apocrine adenoma, atypical apocrine adenosis and granular apocrine metaplasia, in addition to apocrine carcinoma.K Ke ey y W Wo or rd ds s: : Breast; carcinoma; diagnostic errors Ö ÖZ ZE ET T Memenin apokrin karsinomu, invaziv meme kanserleri arasında oldukça nadir görülür. En sık postmenapozal kadınlarda unilateral ve multisentrik olarak ortaya çıkar. Yetmiş altı yaşında kadın hasta, sol memede yaklaşık 12 yıldır şişlik ve meme başında retraksiyon, meme başı akıntısı ve meme derisinde yara oluşması şikayeti ile başvurdu. İnce iğne aspirasyon sitolojisinde (İİAS); nekroz zemininde, üç boyutlu kümeler oluşturan iri hiperkromatik nükleuslu, granüler stoplazmalı, apokrin benzeri hücreler saptanarak şüpheli malign tanısı verildi. Daha sonra yapılan basit mastektomide apokrin karsinom tanısı verildi. Apokrin hücreler varlığında preoperatif ayırıcı tanıda; apokrin adenoma, atipik apokrin metaplazi, apokrin komponentli kompleks sklerozan lezyonlar gibi benign durumların yanısıra apokrin karsinom da akılda tutulmalıdır.A An na ah ht ta ar r K Ke el li im me el le er r: : Meme; karsinom; tanısal hatalar T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J M Me ed d S Sc ci i 2 20 01 13 3; ;3 33 3( (2 2)

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Section: Medical Pathologysupporting

confidence: 48%

Diagnostic Pitfalls in Fine Needle Aspiration Cytology of Apocrine Carcinoma of the Breast: Case Report

Şahin¹,

Aktepe²,

Dılek³

et al. 2013

Turkiye Klinikleri J Med Sci

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“…Kopans et al . suggested in their study that, radiologically, these tumours might present distinctive characteristics, with a higher incidence of ‘mixed‐form’, diffusely‐scattered calcifications in tumours with apocrine features . However, Gilles et al .…”

Section: Discussionmentioning

confidence: 87%

“…Kopans et al suggested in their study that, radiologically, these tumours might present distinctive characteristics, with a higher incidence of 'mixed-form', diffusely-scattered calcifications in tumours with apocrine features. 7 However, Gilles et al studied 16 invasive apocrine carcinomas and showed that their mammographic presentation did not differ from other breast carcinomas. 8 Bilateral breast US and breast MRI were performed for the present case.…”

Section: Discussionmentioning

confidence: 99%

Apocrine carcinoma of the male breast

2012

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Apocrine carcinoma of the male breast is an extremely rare tumour. Only two cases have been published in the medical literature. There is insufficient data about clinical presentation, management and prognostic features of apocrine carcinoma in the male breast. In this study, the clinical presentation, magnetic resonance imaging and histopathological features and management of a 76‐year‐old male with apocrine carcinoma in the left breast are discussed. We present, to best of our knowledge, the third case of apocrine carcinoma of the male breast in medical literature.

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“…From the mammographies, the calcific debris was identified as milk of calcium and hence, escaped the benign cyst lumen during the sectioning, as well as the transfer to glass slides, and staining. Kopans et al (5) described 10 cases of typically benign calcifications associated with malignant cells, including milk of calcium layering in the dependent portion of cystically dilated acini lined with malignant cells. Even so, the classic crescent-shaped calcium precipitated in the cysts, and the spherical centrally lucent calcium deposits are almost always associated with the benign processes.…”

Section: Discussionmentioning

confidence: 99%