Mixed exposure effect of seminal metals on semen quality, mediation of total antioxidant capacity, and moderation of GSTM1/GSTT1 gene deletion in Chinese reproductive-aged men

Ren, Jun; Jin, Huidong; Zhang, Chen; Liu, Song; Han, Yufen; Xi, Jinyan; Cao, Jinhu; Lin, Fenglong; Zhang, Pingyang; Zhang, Fengquan; Zhang, Guanghui; Yang, Huijun; Huang, He‐Feng; Cao, Jun

doi:10.1016/j.envres.2023.115888

Cited by 5 publications

(2 citation statements)

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“…Because metals are usually interrelated in the environment, they can exhibit mutual promotion or inhibition, suggesting synergistic or antagonistic effects on human health [ 41 , 42 , 43 ]. In this study, several models were used to determine the effects of mixed metal exposure on lung functions.…”

Section: Discussionmentioning

confidence: 99%

“…Metals are fixed in the environment, but environmental metal distribution can be changed by anthropogenic activities, making adults, especially those in industrial occupations, more prone to metal exposure compared with children and the elderly. The interrelation among metals in the environment suggests potential synergistic or antagonistic effects on human health [ 41 , 42 , 43 ], posing greater health risks in mixed exposures. Children and the elderly benefit from protective policies against toxic substances, whereas less attention is paid to normal adults, making them the group with the highest exposure risk to toxic metal species [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

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The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

Chen,

Gu,

Zhou

et al. 2024

Metabolites

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Herein, we explored the overall association between metal mixtures and lung functions in populations of varying ages and the relationship among the associated components. The 2007–2012 National Health and Nutrition Examination Survey data of 4382 American participants was analyzed, and generalized linear, elastic net, quantile g–computation, and Bayesian kernel machine regression models were used to evaluate the relationship between exposure to the metal mixture and lung function at various ages. The results of barium exposure at distinct stages revealed that children and adolescents exhibited greater lung function changes than those in adults and the elderly. Additionally, compared with children and adolescents, cadmium– and arsenic–containing metabolites contributed to nonconductive lung function changes in adults and the elderly exposed to metal mixtures. The results showed that the effects of exposure to metal mixtures on lung function in children and adolescents were predominantly caused by lead and barium. Altogether, children and adolescents were found to be more susceptible to metal–exposure–mediated lung function changes than adults and the elderly.

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Section: Discussionmentioning

confidence: 99%