Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma

Buritica, C.; Serrano, Marta; Zuluaga, Armando; Arrabal, María del Carmen Leiva; Regauer, Sigrid; Nogales, Francisco F.

doi:10.1136/jcp.2005.031294

Cited by 18 publications

(10 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This mixture of various types of these Müllerian epithelia can often be seen within a single tumor mass in MESTK [16]. In addition, the ovarian stroma of MESTK can infrequently reveal fibrous areas indistinguishable from corpora albicantia [15], and rarely, there may even be lutein stromal cells identical to those seen in the ovaries [4]. Such epithelial and stromal features are never seen in RATs.…”

Section: Discussionmentioning

confidence: 94%

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

et al. 2008

View full text Add to dashboard Cite

We present a series of a distinct tumorous entity named renal angiomyoadenomatous tumor (RAT). Five cases were retrieved from the consultation files of the authors. Histologic and immunohistochemical features were evaluated. Sequencing analysis of coding region of the VHL gene was carried out in all cases. The tumors were composed of admixture of an epithelial clear cell component and prominent leiomyomatous stroma. Epithelial cells formed adenomatous tubular formations endowed with blister-like apical snouts. All tubular/glandular structures were lined by a fine capillary network. The epithelial component was positive for epithelial membrane antigen, CK7, CK20, AE1-AE3, CAM5.2, and vimentin in all cases. In all analyzed samples, no mutation of the VHL gene was found. RAT is a distinct morphologic entity, being different morphologically, immunohistochemically, and genetically from all renal tumors including conventional clear cell carcinoma and mixed epithelial and stromal tumor of kidney.

show abstract

Section: Discussionmentioning

confidence: 94%

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

et al. 2008

View full text Add to dashboard Cite

show abstract

“…52 The ovarian stromal components of both pancreatic mucinous cystic neoplasms and renal mixed epithelial stromal tumors are also reactive with inhibin. 4,48 Similarly, SF-1 reactivity in primary gonadal sex-cord stromal tumors may show staining in metastatic foci. 41,51,52 In summary of this tissue microarray study, we have shown that using an antibody panel comprised of chromogranin plus SF-1 and either calretinin or inhibin (while maintaining a Z2+ staining intensity threshold) is most effective in distinguishing adrenal cortical lesions from pheochromocytomas.…”

Section: Discussionmentioning

confidence: 98%

A Tissue Microarray-based Comparative Analysis of Novel and Traditional Immunohistochemical Markers in the Distinction Between Adrenal Cortical Lesions and Pheochromocytoma

Sangoi¹,

McKenney

2010

American Journal of Surgical Pathology

View full text Add to dashboard Cite

We have encountered an increasing number of image-guided adrenal mass biopsies in which the differential diagnosis is adrenal cortical lesion versus pheochromocytoma. This distinction is sometimes difficult because of confounding clinical presentations, overlapping morphologies, and some degree of immunophenotypic overlap including focal staining with markers of purported lineage specificity. Interventional radiologists commonly use narrow gauge biopsy needles in this setting, which yield scant diagnostic tissue and further complicate pathologic evaluation. In this study, a detailed immunoprofile of 63 adrenal cortical lesions (3 adrenal rests, 6 adrenal cortical hyperplasias, 43 adrenal cortical adenomas, 4 adrenal cortical neoplasms of uncertain malignant potential, and 7 adrenal cortical carcinomas) was compared with 35 pheochromocytomas using traditional (calretinin, chromogranin, inhibin, melanA, and synaptophysin) and novel [steroidogenic factor-1 (SF-1), microtubule-associated protein 2, and mammalian achaete-scute homolog-1] antibodies, using tissue microarray technology to simulate small image-guided biopsies. Staining extent and intensity were each scored semiquantitatively for each antibody. A comparison of sensitivity and specificity using different intensity thresholds required for a "positive" result (> or = 1+ vs. > or = 2+) was performed. Staining results based on a > or = 1+ and (> or = 2+) intensity threshold were as follows: calretinin-95% (89%) in adrenal cortical lesions and 14% (0%) in pheochromocytomas; chromogranin-0% in adrenal cortical lesions and 100% in pheochromocytomas; inhibin-97% (86%) in adrenal cortical lesions and 6% (0%) in pheochromocytomas; microtubule-associated protein 2-29% (16%) in adrenal cortical lesions and 100% (89%) in pheochromocytomas; mammalian achaete-scute homolog-1-0% in both adrenal cortical lesions and pheochromocytomas; melanA-94% (86%) in adrenal cortical lesions and 6% (0%) in pheochromocytomas; SF-1-87% (86%) in adrenal cortical lesions and 0% in pheochromocytomas; synaptophysin-67% (59%) in adrenal cortical lesions and 100% in pheochromocytomas. Using an antibody panel consisting of chromogranin plus the nuclear antibody SF-1 and either calretinin or inhibin, while requiring a high-staining intensity threshold, helps to eliminate interpretative issues of artifactual or background reactivity, improves diagnostic sensitivity/specificity, and makes for an effective immunohistochemical approach in distinguishing adrenal cortical lesions from pheochromocytomas.

show abstract

“…Although there are case reports and series in the pathology literature [1][2][3]6,7,[9][10][11][12][13][14]16,17] there are few published reports describing the imaging findings of MEST [5,8,19]. To the best of our knowledge, the largest radiological study described the imaging features in three patients [5].…”

Section: Introductionmentioning

confidence: 94%

“…A strong association with oestrogen exposure was proposed. Of the 90 patients reported who had MEST [1][2][3][5][6][7][8][9][10][11][12][13][14][15][16][17][18], almost all have been women [2,4]. Many of these patients were perimenopausal with a history of long-term oestrogen replacement at the time of diagnosis [2].…”

Section: Introductionmentioning

confidence: 99%

Mixed epithelial and stromal tumour of the kidney: imaging features

et al. 2010

View full text Add to dashboard Cite

Study Type – Diagnosis (case series) Level of Evidence 4OBJECTIVETo describe the features on ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) of mixed epithelial and stromal tumours of the kidney.PATIENTS AND METHODSFive women with renal mixed epithelial and stromal tumours (mean age 55.6 years, range 49–59) who had preoperative imaging were retrospectively analysed. Three ultrasonograms, five contrast‐enhanced CT scans, and one contrast‐enhanced MRI examination were available for review. Specific imaging features analysed included lesion size, location, enhancement and cystic composition. The presence of calcification, septation, nodularity and a capsule were also evaluated.RESULTSAll mixed epithelial and stromal tumours appeared as well‐marginated, multi‐septate cystic masses with a nodular component. All lesions were classified as Bosniak category III (three) or IV (two). The presence of calcification (four) or a capsule (three) was variable. Two tumours invaginated into the renal pelvis with no invasion.CONCLUSIONMixed epithelial and stromal tumours of the kidney have a diverse radiographic appearance, indistinguishable from multilocular cystic nephroma and cystic renal cell carcinoma.

show abstract

Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma

Cited by 18 publications

References 15 publications

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

Renal angiomyoadenomatous tumor: morphologic, immunohistochemical, and molecular genetic study of a distinct entity

A Tissue Microarray-based Comparative Analysis of Novel and Traditional Immunohistochemical Markers in the Distinction Between Adrenal Cortical Lesions and Pheochromocytoma

Mixed epithelial and stromal tumour of the kidney: imaging features

Contact Info

Product

Resources

About