Mixed epithelial and stromal tumor—adult cystic nephroma of the kidney: a case report with immunohistochemical analysis

Karasavvidou, Foteini; Mitrakas, Lampros; Tzika, Styliani; Zachos, Ioannis; Anagnostou, Athanasios; Tzortzis, Vassilios

doi:10.1093/jscr/rjac387

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…This case highlights the challenges in diagnosing mixed epithelial and stromal renal tumors, which can mimic benign renal cysts as well as the importance of thorough investigation and consideration of atypical aetiologies in patients with longstanding symptoms attributed to renal cysts [ 6,7 ] . The successful management through laparoscopic deroofing emphasizes the importance of using minimally invasive techniques for diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

Mukendi,

de Heer‐Menlah Phaladi,

Mathye

2024

UroPrecision

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BackgroundRenal cysts are common in clinical practice, but some may harbor rare pathological entities such as mixed epithelial and stromal tumors (MEST). Imaging studies are crucial for accurate diagnosis. While laparoscopic deroofing is an established approach for symptomatic renal cysts, encountering MEST within a cyst is uncommon.Case PresentationWe present the case of a 37‐year‐old female who presented with persistent left flank pain. Imaging revealed a large renal cyst in the lower pole of the left kidney, classified as Bosniak 2. Despite analgesia, the patient's symptoms persisted, leading to a laparoscopic deroofing procedure. Histopathological examination postprocedure revealed a MEST. The patient reported complete resolution of symptoms at the 3‐month follow‐up.ConclusionThis unique case presents the successful identification and surgical management of a MEST masquerading as a lower pole renal cyst through laparoscopic deroofing. It also contributes to the existing literature by highlighting the importance of considering rare pathological entities in the evaluation of renal cysts and the value of laparoscopic techniques in their management.

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Section: Discussionmentioning

confidence: 99%

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

Mukendi,

de Heer‐Menlah Phaladi,

Mathye

2024

UroPrecision

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“…Чаще всего данные опухоли являются случайной находкой [1,26], однако, их рост может характеризоваться типичными клиническими проявлениями для всех типов опухолей почки, такими как боли в поясничной области, боли в животе, макро-и микрогематурия и пр. [14,17,21,27].…”

Section: Discussionunclassified

“…Кисты разного размера и формы, с гладкой и блестящей оболочкой, содержат серозную жидкость [16]. Размер СЭИСО сильно варьирует со средним показателем от 4 до 7 см по данным различных источников [15,16,20,21,26,35,36]. Сообщается, что некоторые опухоли могут вызывать компрессию чашечно-лоханочной системы [21], но истинная жировая инфильтрация синуса встречается редко [27].…”

Section: Discussionunclassified

“…Также отмечено, что в строме яичникового типа отмечается экспрессия ингибина, кальретинина и Forkhead Box L2 (FOXL2) [43]. Для эпителиального компонента характерна экспрессия цитокератинов, Paired Box 2 (PAX2) и Paired Box 8 (PAX8), а также вариабельно ER и PR [26,35,44]. В 57% случаев была обнаружена коэкспрессия GATA Binding Protein 3 (GATA3) и PAX8 [15].…”

Section: Discussionunclassified

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Mixed epithelial and stromal tumor in combination with oncocytoma of the kidney: a rare clinical case and review of the literature.

E.V.,

А.А.,

P.O.

et al. 2024

ECU

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Introduction. Mixed epithelial and stromal tumors (MEST) of the kidney are rare neoplasms and, along with adult cystic nephroma, are grouped together called mixed epithelial and stromal tumors (World Health Organization Classification of Tumors of the Kidney, 2022). Clinically and radiologically, they mimic other cystic renal neoplasms, thus definitive diagnosis requires histological and immunohistochemical examination. Despite the benign course, MEST can undergo malignancy; isolated cases of recurrence have also been documented. Clinical case. Patient X, 65 years old, underwent robot-assisted left-side partial nephrectomy for cystic formations of the left kidney with a hypervascular soft tissue component along the medial semicircle of one of the cysts. According to histological examination, MEST of the left kidney in combination with oncocytoma was diagnosed. Conclusions. This article presents probably the first published case of MEST in combination with oncocytoma of the kidney.

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“…It exhibits a complex architecture with both solid and cystic elements, comprised of dilated tubules and cysts lined by cuboidal to columnar epithelium, frequently presenting a distinctive "hobnail" appearance on the surface [ 2 ]. Among all renal cancers, MEST accounts for only 0.2% [ 3 ]. While the majority of cases exhibit a benign clinical course with favorable outcomes, there is a potential for malignant transformation, as documented in isolated cases in the literature [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Unmasking the Mystery of Renal Neoplasm in a Perimenopausal Woman: A Case Report

Dharwadkar,

Gore,

Bhuibhar

et al. 2024

Cureus

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Mixed epithelial and stromal tumor (MEST) is a benign, complex, and rarely encountered renal neoplasm. This case involves a 46-year-old perimenopausal woman who presented with symptoms, such as abdominal pain, burning sensation during urination, increased urinary frequency, and hesitancy. Computed tomography (CT) urography revealed an exophytic, heterogeneously hyperdense mass originating from the interpolar and lower pole parenchyma of the left kidney, suggesting a neoplastic origin. Due to concerns about malignancy and the presence of local symptoms, a laparoscopic-assisted left radical nephrectomy was performed. Histopathological examination of the excised tissue revealed a biphasic neoplasm consisting of epithelial and stromal elements. The epithelial component exhibited cysts and glands of variable sizes, lined by columnar cells and surrounded by stromal tissue. The diagnosis of MESTs of the kidney was established and confirmed through immunohistochemistry. This unique type of benign kidney tumor can be effectively managed through conservative surgery and is associated with a favorable prognosis.

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Mixed epithelial and stromal tumor—adult cystic nephroma of the kidney: a case report with immunohistochemical analysis

Cited by 3 publications

References 13 publications

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

Successful management of a mixed epithelial and stromal renal tumor masquerading as lower pole renal cyst: A laparoscopic deroofing approach

Mixed epithelial and stromal tumor in combination with oncocytoma of the kidney: a rare clinical case and review of the literature.

Unmasking the Mystery of Renal Neoplasm in a Perimenopausal Woman: A Case Report

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