Mixed Epithelial and Stromal Tumor of the Kidney with Extension into Inferior Vena Cava: Case Report and Discussion of Adult Biphasic Cystic Renal Lesions and the Significance of Vascular Involvement

Picken, Maria M.; Bova, Davide; Pins, Michael; Quek, Marcus L.

doi:10.1155/2018/8234295

Cited by 10 publications

(20 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 It is still debated whether SMART represent a distinct entity or may be considered a variant of MEST with an exaggerated epithelial component. 17 In our case, the TLF epithelial nodule was well circumscribed and partially encapsulated as opposed to adenomatous proliferations intimately admixed with stroma.…”

Section: Discussionmentioning

confidence: 45%

“…The vast majority of MEST cases are benign, however, malignant sarcomatous or carcinosarcomatous transformation, local extension into the inferior vena cava, and rare cases of borderline or malignant epithelial tumors including RCC have been reported. [13][14][15][16][17][18] All these studies suggest that both stromal and epithelial components of MEST are neoplastic and have malignant potential in rare cases.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Thyroid-Like Follicular Renal Cell Carcinoma Arising Within Benign Mixed Epithelial and Stromal Tumor

Tretiakova

Kehr²,

Gore

et al. 2019

Int J Surg Pathol

View full text Add to dashboard Cite

Thyroid-like follicular renal cell carcinoma (TLF-RCC) is an extremely rare tumor with less than 40 published reports. These tumors are morphologically distinct with striking resemblance to thyroid follicular tumors, but immunohistochemically different due to lack of thyroglobulin and thyroid transcription factor 1 expression. TLF-RCCs arise in younger patients (mean age = 41 years) with female predominance and in all reported cases were solitary tumors without coexisting epithelial or mesenchymal kidney neoplasms. In this article, we report a case of a 42-year-old woman who presented with an incidental 4-cm solid and cystic left renal mass of the upper pole, which was resected. A detailed imaging assessment, pathologic findings, and immunohistochemical studies revealed a partially encapsulated TLF-RCC arising in a background of mixed epithelial and stromal tumor.

show abstract

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 98%

Thyroid-Like Follicular Renal Cell Carcinoma Arising Within Benign Mixed Epithelial and Stromal Tumor

Tretiakova

Kehr²,

Gore

et al. 2019

Int J Surg Pathol

View full text Add to dashboard Cite

show abstract

“…14 The presence of vascular invasion does not appear to affect the excellent prognosis associated with these tumours.…”

Section: Discussionmentioning

confidence: 93%

“…Vascular invasion has also been described in other rare benign renal neoplasms including anastomosing haemangioma 13 and mixed epithelial and stroma tumour of the kidney. 14 The presence of vascular invasion does not appear to affect the excellent prognosis associated with these tumours. 16,17 A common diagnostic challenge is distinguishing the eosinophilic variant of ChRCC and oncocytoma.…”

Section: Discussionmentioning

confidence: 93%

Renal oncocytoma with vascular and perinephric fat invasion

Omiyale

Carton

2019

Therapeutic Advances in Urology

View full text Add to dashboard Cite

Renal oncocytoma is a benign epithelial neoplasm typically composed of large cells with granular eosinophilic cytoplasm. Although rare, histologically worrisome features such as vascular and perinephric fat invasion have been reported. Of the 159 renal oncocytomas resected at our institution, 20 (12.6%) had vascular and/or perinephric fat invasion. Microscopically, 10 oncocytomas had perinephric fat invasion, 7 had vascular invasion and 3 had both vascular and perinephric fat invasion. Grossly, perinephric fat invasion was visible in three cases and tumour was identified within the branches of the renal vein in two cases. Tumours occurred in 14 men and 6 women (M:F = 2.3:1). The mean age at diagnosis was 64.5 years (range, 33–88 years). A total of 11 cases had radical nephrectomies while 9 cases had partial nephrectomies. There was no evidence of disease recurrence, metastasis or death due to tumour after a mean follow up of 25.6 months (range, 2–103 months). The presence of vascular and perinephric fat invasion in renal oncocytoma though worrisome, does not alter the benign course of the tumour.

show abstract

“…This neoplasm has a bimodal distribution, in children under 4 years and in adults ranged from 40 to 65 years, much more frequent in women with a ratio of 8/1 [28]. Before the operation, CN doesn't have any specific clinical presentation or any distinctive imaging features from other renal cystic lesions, in particular MEST and CCRC [29]. Pathogeny of this entity is unknown and it has been proposed that the epithelial stromal components of the tumor are neoplastic.…”

Section: Discussionmentioning

confidence: 99%

Renal Cystic Nephroma: Histologic and Immunohistochemical Analyses and Review of Literature

Darouichi¹,

Jp²,

Pe³

2019

Arch Clin Biomed Res

View full text Add to dashboard Cite

Background: A case of renal Cystic Nephroma (CN) was reported in 32 years-old women presenting with an incidental renal mass on radiological imaging. Methods:On CT-scan examination, a renal cell carcinoma was suspected and right nephrectomy was performed. The resected tumor measured 17 × 10 × 7 cm. Macroscopically, the tumor was a multilocular mass with cysts ranging from 0.5 cm to 4.5 cm. The tumor was well delineated relative to non-tumoral renal parenchyma, which was physiological in appearance with a cortex at 1 cm without evidence of infiltration of the tumor. At the hilum, the arterial, venous and ureter were normal. No lymph node was identified. Microscopically, the lesion was well defined by a fibrous capsule, consisting of multiple cystic formations of variable sizes bordered by a mono-stratified epithelium, which ranged from flat to cubic.The lining epithelial cells had a hobnail appearance, abundant cytoplasm and an oval nucleus associated with a nucleolus.No mitosis were founded. The cysts were subtended by cellular fibrous septa of ovarian type. On immunohistochemical examination, the epithelial cells were positive for cytokeratins 7 and 19; stromal cells were positive for estrogen receptors, progesterone receptor and CD10. In the septa, there were some bundles of smooth muscle cells positive for desmin and smooth muscle actin. Conclusion:The patient was alive 8 years after treatment, without metastasis or recurrence. Histologic and immunohistochemical analyses may be helpful in differential diagnosis between benign cystic renal neoplasms, CN, mixed epithelial and stromal tumor (MEST) and malignant tumors such as clear cell renal carcinoma (CCRC) in adults.

show abstract

Mixed Epithelial and Stromal Tumor of the Kidney with Extension into Inferior Vena Cava: Case Report and Discussion of Adult Biphasic Cystic Renal Lesions and the Significance of Vascular Involvement

Cited by 10 publications

References 40 publications

Thyroid-Like Follicular Renal Cell Carcinoma Arising Within Benign Mixed Epithelial and Stromal Tumor

Thyroid-Like Follicular Renal Cell Carcinoma Arising Within Benign Mixed Epithelial and Stromal Tumor

Renal oncocytoma with vascular and perinephric fat invasion

Renal Cystic Nephroma: Histologic and Immunohistochemical Analyses and Review of Literature

Contact Info

Product

Resources

About