Mixed Epithelial and Stromal Tumor of the Kidney: Preliminary Immunohistochemical and Electron Microscopic Studies of the Epithelial Component

Picken, Maria M.; Fresco, Raoul

doi:10.1080/01913120590951275

Cited by 19 publications

(19 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with the previous reports of malignant MEST, which also describe a benign epithelial component associated with malignant stroma [6][7][8]. Interestingly, a recent study by Picken and Fresco [12] suggests that the epithelial component of MEST may represent entrapped nonneoplastic tubules, which may explain our observation [13]. Malignantappearing cells were present throughout the stroma; curiously however, the regions of stromal condensation associated with the epithelial components, the ovarian-like regions, showed a greater degree of atypical cytologic features and more brisk mitotic activity relative to the regions more distant to the epithelial components where the stroma assumed a looser arrangement.…”

Section: Discussionsupporting

confidence: 90%

Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors

et al. 2007

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 90%

Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors

et al. 2007

View full text Add to dashboard Cite

“…Its histogenesis remains uncertain. However, preliminary EM studies [32] suggest that the epithelial component may be entrapped rather than neoplastic. Again, additional EM studies may be helpful in addressing this issue.…”

Section: Other Tumorsmentioning

confidence: 94%

The Evolving Concept of Renal Neoplasia: Impact of Emerging Molecular and Electron Microscopic Studies

Picken

2005

Ultrastructural Pathology

View full text Add to dashboard Cite

The classification of renal tumors has evolved from one that initially encompassed only 2 types of tumors, i.e., clear and granular cell carcinomas, to the markedly expanded recent classification that incorporates new entities, some of which are primarily defined by specific molecular abnormalities. Despite these advances, a single tumor category, clear cell carcinoma, still incorporates the majority (approximately 70%) of renal tumors. It is, however, postulated that this single category is likely to encompass several different tumor types that are, at present, undifferentiated. Electron microscopic studies have been pivotal in defining the spectrum of oncocytoma-chromophobe renal cell carcinoma. Cytoplasmic eosinophilia found in some renal cell carcinomas currently classified as clear cell type is under intense study. Tumors that have recently emerged from this group include tumors with translocations involving chromosome Xp11.2, carcinomas associated with neuroblastoma and epithelioid angiomyolipoma. The spectrum of renal tumors seen in younger patients is wider than among older patients, with rare and unusual tumors being more likely seen in younger patients. The author concludes that although the routine application of electron microscopy to kidney tumor diagnosis may not be practical, systematic ultrastructural studies of these tumors may aid in the definition of new entities.

show abstract

“…Both entities show some remarkable similarities including sex predilection, age distribution, and morphological attributes of the epithelial and stromal components as well as immunohistochemical profile [15]. Albeit there are some variations in the individual categories with a higher prevalence of stromal-to-epithelial ratio, prominent ovarian stroma, smaller cysts more common in MEST; in contrast larger cysts with only thin septa (with septa being smaller than 5 mm) and in addition a lower stromal-to-epithelial ratio are typically observed in cystic nephroma [2].…”

Section: Discussionmentioning

confidence: 99%

Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity

et al. 2010

View full text Add to dashboard Cite

BackgroundMixed epithelial and stromal tumour (MEST) represents a recently described benign composite neoplasm of the kidney, which predominantly affects perimenopausal females. Most tumours are benign, although rare malignant cases have been observed.Case reportA 47-year-old postmenopausal female presented to the urologist with flank pain. A CT scan of the abdomen showed a 30-mm-in-diameter uniform mass adjacent to the pelvis of the left kidney. Surgical exploration showed a tumour arising from the lower anterior hilus of the left kidney. The tumour could be excised by preserving the kidney. By intraoperative frozen section the tumour showed characteristic features of MEST with epithelial-covered cysts embedded in an "ovarian-like" stroma. Additional immunohistochemistry investigations showed expression for hormone receptors by the stromal component of the tumour.DiscussionMEST typically presents in perimenopausal women as a primarily cystic mass. Commonly, the tumour arises from the renal parenchyma or pelvis. The tumour is composed of an admixture of cystic and sometimes more solid areas. The stromal cells typically demonstrate an ovarian-type stroma showing expression for the estrogen and progesterone receptors.ConclusionMEST represents a distinctive benign tumour entity of the kidney, which affects perimenopausal woman. The tumour should be distinguished from other cystic renal neoplasms. By imaging studies it is difficult to distinguish between a benign or malignant nature of the tumour. Thus, intraoperative frozen section is necessary for conservative surgery, since the overall prognosis is favourable and renal function can be preserved in most cases.

show abstract

Mixed Epithelial and Stromal Tumor of the Kidney: Preliminary Immunohistochemical and Electron Microscopic Studies of the Epithelial Component

Cited by 19 publications

References 3 publications

Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors

Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors

The Evolving Concept of Renal Neoplasia: Impact of Emerging Molecular and Electron Microscopic Studies

Exophytic benign mixed epithelial stromal tumour of the kidney: case report of a rare tumour entity

Contact Info

Product

Resources

About