Mixed-effects models: Family burden and functionality in patients with bipolar disorder

Abstract

IntroductionThe bipolar disorder (BD) has an important effect over the lives of patients and families. The attitude of the family is a modifiable factor through specific interventions and it has been related with BD prognosis.ObjectivesStudy a sample of families and patients with BD.AimsCompare between two groups its course of burden of caring for family members with BD. Also, we will see the course of the functionality in patients.MethodsSample of 148 individuals who caring a familiar with BD. Seventy-six of these followed psychoeducation session are going to be experimental group (EG), and the others 72 did not followed any session are going to be control group (CG). There is a follow-up at 6 months and one year. To see the course of the burden and the functionality it will be used mixed models.ResultsAt baseline, there were not significant differences between CG and EG in objective and subjective burden and functionality. But over time there were significant results in the three cases. For objective burden (b = −0.016; P = 0.0001) EG presented a drop (b = −0.014; P = 0.0062), while CG did not show changes (b = 0.002; P = 0.4691). For subjective burden (b = −0.014; P = 0.0058) without significant results for CG (b = −0.352; P = 0.3203) and a significant decrease in EG (b = −0.017; P = 0.003). For the functionality (b = 1.474; P = 0.000) there was a significant increase in EG (b = 1.349; P = 0.000) but not for CG (b = −0.125; P = 0.3828).ConclusionsTwo groups did not differ at baseline however after the psychoeducation sessions appear clear differences, decreasing the burden for EG group and the functionality also improved for EG.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Promoting medication adherence among patients with bipolar disorder: a multicenter randomized controlled trial of a multifaceted intervention

“…The beneficial effects of psychoeducation for patients with BD have been demonstrated on a number of different outcomes, including MA, insight improvement, and a reduction in symptoms relief for people with BD (Bilderbeck et al, 2016, Hidalgo-Mazzei et al, 2016, Kallestad et al, 2016, Rouget and Aubry, 2007. Similar interventions have also been shown to reduce the burden of care, as well as distress among family members (Bermúdez-Ampudia et al, 2016, Hubbard et al, 2016. Given that patients with BD can differ in their responses to the same intervention (Culpepper, 2014), it is possible that a multifaceted intervention that targets various reasons for non-adherence might result in even better outcomes.…”