Mixed cryoglobulinemia: Clinical aspects and long-term follow-up of 40 patients

Gorevic, Peter D.; Kassab, Hannah Jane; Levo, Y; Kohn, R; Meltzer, M.; Prose, Philip H.; Franklin, Edward C.

doi:10.1016/0002-9343(80)90390-3

Cited by 711 publications

(340 citation statements)

References 146 publications

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“…Anemia occurs in 70%of cases (6), but evaluation for specific etiologies are generally unrevealing. Rare cases of type II cryoglobulinemia associated with hemolytic anemia have been reported (6). In the present case, hematologic data suggested the possibility that the anemia was accompanied by chronic inflammation.…”

Section: Discussionsupporting

confidence: 51%

“…Hepatic involvement of cryoglobulinemia has been reported in 8%of cases and an elevated level of serum alkaline phosphatase is known to be the most frequent abnormality (6). Although there have been manyreports on the association between cryoglobulinemia and hepatitis virus infection (7-9), the present patient had no history of liver diseases or serologic evidence of viral hepatitis.…”

Section: Discussionmentioning

confidence: 59%

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Mixed-Cryoglobulinemia Associated with Cutaneous Vasculitis and Pulmonary Symptoms.

et al. 1997

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A 45-year-old Japanese man with Sjogren's syndrome developed recurrent skin ulcers, palpable purpura, and dyspnea. Serum mixed-type cryoglobulin level was elevated. A biopsy of his skin lesion showedthe characteristic leukocytoclastic vasculitis of mixed-type cryoglobulinemia. Dyspnea, skin ulcers, and purpura resolved along with a reduction in the serum cryoglobulin level after prednisolone administration. This patient demonstrated cryoglobulinemia-associated vasculitis, as well as possible cryoglobulinemia-associated pulmonary symptoms. (Internal Medicine 36: 62-67, 1997)

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 59%

Mixed-Cryoglobulinemia Associated with Cutaneous Vasculitis and Pulmonary Symptoms.

et al. 1997

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“…His liver function also improved, and absolute lymphocytosis and atypical lymphocytes were not Immunoblot showing plateletproteins recognizedby the patient's plasma. Normal washed platelet membraneprotein was electrophoresed on sodium dodecyl sulfate polyaerylamide gels under nonreducing (1 , 3, 5, 7) and reducing (2,4,6,8) conditions, transferred to nitrocellose sheets and incubated with plasma from the patient on his 10th (1)(2)(3)(4) and 53rd (5-8) days in hospital. Bound anti-platelet antibodies were detected by the Avidin-Biotin-Peroxidase complex method using biotinylated anti-human IgM (1,2,5,6) and IgG (3,4,7,8 present by day 1 8.…”

Section: Case Reportmentioning

confidence: 99%

Cytomegalovirus Mononucleosis with Mixed Cryoglobulinemia Presenting Transient Pseudothrombocytopenia.

et al. 1993

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A 61-year-old manwas admitted to our hospital because of fever and general malaise. We diagnosed his condition as cytomegalovirus (CMV)mononucleosis by hematological testing. His platelet count was decreased in spite of collection with several anticoagulants at room temperature (20°C) ; no decrease was observed at 37°C. Mixed cryoglobulinemia, monoclonal IgM and polyclonal IgG, which acted as anti-platelet antibodies in cold condition, were found in the patient's serum. With the resolution of CMVinfection, the cryoglobulins disappeared and the platelet count returned to normal without platelet agglutination. This is the first report of transient pseudothrombocytopenia in CMVmononucleosis with mixed cryoglobulinemia. (Internal Medicine 32: 598-601, 1993)

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“…Tissue injury in HCV-related mixed cryoglobulinemia is probably due to the vascular deposition of circulating HCV-containing immune complexes (6,7). Similarly, in general population of HCV-positive patients, the appearance of various types of organ involvement can be related to different immunological factors, including autoantibody and immune complex production secondary to B-lymphocyte expansion (8,9). HCV-induced autoantibodies or circulating immunecomplexes reported to be contributed to the polymyositis and pulmonary fibrosis (10).…”

Section: Introductionmentioning

confidence: 99%

Polymyositis, Pulmonary Fibrosis and Malignant Lymphoma Associated with Hepatitis C Virus Infection.

et al. 2001

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Polymyositis has been associated with various viral infections, and a spectrum of immune-relateddiseases may occur with hepatitis C (HCV) infection. Both polymyositis and HCVinfection may be accompanied by pulmonary fibrosis. Anassociation between polymyositis and malignancy has also been reported. Wereport a 55-year-old woman acompanied cryoglobulinemia with HCVinfection and manifesting polymyositis, pulmonary fibrosis and malignant lymphoma.Steroid therapy was effective to improve interstitial pneumonia, polymyositis, and liver function.

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Mixed cryoglobulinemia: Clinical aspects and long-term follow-up of 40 patients

Cited by 711 publications

References 146 publications

Mixed-Cryoglobulinemia Associated with Cutaneous Vasculitis and Pulmonary Symptoms.

Mixed-Cryoglobulinemia Associated with Cutaneous Vasculitis and Pulmonary Symptoms.

Cytomegalovirus Mononucleosis with Mixed Cryoglobulinemia Presenting Transient Pseudothrombocytopenia.

Polymyositis, Pulmonary Fibrosis and Malignant Lymphoma Associated with Hepatitis C Virus Infection.

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