Mixed corticomedullary tumour with myelolipoma: a rare coexistence

Singh, Meeta; Mandal, Shramana; Kakkar, Arun; Khurana, Nita; Garg, Ankur

doi:10.3109/00313025.2010.508741

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…As the two components of the adrenal gland have different embryological origins, it is not surprising that mixed corticomedullary tumors are rare. A total of twenty eight patients with adrenal mixed corticomedullary tumors have been described [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Of these, only three had malignant mixed corticomedullary tumors [ 16 , 23 , 24 ] and one [ 16 ] among those succumbed rapidly to their disease.…”

Section: Discussionmentioning

confidence: 99%

Mixed Corticomedullary Tumor of the Adrenal Gland: A Case Report and Literature Review

Maradana,

Edem,

Menon

et al. 2023

Medicina

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Adrenal mixed corticomedullary tumors (MCMTs) are composed of an admixture of cortical and medullary cells. Owing to the presence of two distinct components of different embryonic lineage, these tumors are extremely rare. Less than 30 tumors of this type have been reported to date. MCMTs have varied presentation including hypertension, Cushing syndrome or even as adrenal incidentalomas. Also noted is a slightly higher female preponderance. We report a case of a 26-year-old female who was evaluated for uncontrolled hypertension. A renal ultrasound followed by MRI abdomen revealed a 9.3 × 8.1 × 7.0 cm partially cystic, partially solid enhancing mass in the region of/replacing the left adrenal gland. Hormonal work-up was significant for elevated catecholamines concerning pheochromocytoma. She underwent laparoscopic left adrenalectomy, with adequate pre-operative adrenergic blockade. Histology and immunochemical testing were consistent with a mixed corticomedullary tumor. She was monitored annually for recurrence of the tumor. We also performed a comprehensive review of literature of the cases published so far to the best of our knowledge.

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Section: Discussionmentioning

confidence: 99%

Mixed Corticomedullary Tumor of the Adrenal Gland: A Case Report and Literature Review

Maradana,

Edem,

Menon

et al. 2023

Medicina

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“…It should be pointed out that myelolipoma can coexist with other tumors as collision tumors, especially when it occurs in the adrenal gland. The most common collision tumor reported is adrenocortical adenoma . In addition, secondary hematopoietic malignancy can be associated with myelolipoma or arise in the background of myelolipoma .…”

Section: Introductionmentioning

confidence: 99%

“…The most common collision tumor reported is adrenocortical adenoma. [9][10][11] In addition, secondary hematopoietic malignancy can be associated with myelolipoma or arise in the background of myelolipoma. [12][13][14] Myeloid sarcoma should be also included in the differential diagnosis, which shows proliferation of highly atypical hematopoietic cells.…”

Section: Introductionmentioning

confidence: 99%

Fine needle aspiration cytology of peripancreatic myelolipoma

Huang

Parmer

Muniraj

et al. 2020

Diagnostic Cytopathology

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Mixed corticomedullary adrenal carcinoma

et al. 2013

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Truly mixed corticomedullary tumors (MCMTs) are extremely rare and present as a single tumor mass composed of an intimately admixed population of both adrenal cortical cells and pheochromocytes. The current study describes the first case of a mixed corticomedullary adrenal carcinoma. In addition, we also review the published data on MCMTs to determine their clinical features, biochemical characteristics, pathological findings, and management. In order to compose this review, a search of the international literature for MCMTs was conducted. Fifteen related articles were found. The clinical and pathological information was obtained for all reported cases. MCMTs were found almost exclusively in females. In the vast majority of patients, the symptoms were related to the tumor's hormone hypersecretion. Hypertension and diabetes were present in 80 and 40 % of cases, respectively. Cushing's syndrome was reported in eight cases (53.33 %). A final diagnosis was made in all cases after surgery based on the pathological results. As of the writing of this article, all published cases of MCMTs had benign clinical behavior, with no instances of metastasis or death due to the tumor. MCMTs are currently considered to be benign tumors. Ours is the first case of malignant MCMT reported in the literature. The potential for malignancy should therefore be considered for these tumors.

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Mixed corticomedullary tumour with myelolipoma: a rare coexistence

Cited by 8 publications

References 8 publications

Mixed Corticomedullary Tumor of the Adrenal Gland: A Case Report and Literature Review

Mixed Corticomedullary Tumor of the Adrenal Gland: A Case Report and Literature Review

Fine needle aspiration cytology of peripancreatic myelolipoma

Mixed corticomedullary adrenal carcinoma

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