Mixed-beam approach for high-risk prostate cancer: Carbon-ion boost followed by photon intensity-modulated radiotherapy. Dosimetric and geometric evaluations (AIRC IG-14300)

Gugliandolo, Simone Giovanni; Marvaso, Giulia; Comi, S.; Pepa, Matteo; Romanò, Chiara; Zerini, Dario; Augugliaro, Matteo; Russo, Stefania; Vischioni, Barbara; Valvo, Francesca; Giandini, T.; Avuzzi, B.; Valdagni, Riccardo; Ciardo, D.; Cobelli, Ottavio De; Jereczek‐Fossa, Barbara Alicja; Cattani, Federica; Orecchia, Roberto

doi:10.1016/j.ejmp.2020.07.012

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…( 4 ). Patients’ enrollment started after trial approval from all treating centers’ Ethical Committees ( 8 ). The selected patients underwent carbon-ion boost at CNAO, followed by photon intensity-modulated radiotherapy (IMRT) at IEO or INT, and signed informed consents at the coordinating center prior to treatment.…”

Section: Methodsmentioning

confidence: 99%

“…We retrospectively analyzed treatment and imaging data of 16 consecutive patients, enrolled from 2016 to 2020 in a phase II study for CIRT boost treatment at CNAO, diagnosed with highrisk PCa according to the inclusion criteria previously described in Marvaso et al (4). Patients' enrollment started after trial approval from all treating centers' Ethical Committees (8). The selected patients underwent carbon-ion boost at CNAO, followed by photon intensity-modulated radiotherapy (IMRT) at IEO or INT, and signed informed consents at the coordinating center prior to treatment.…”

Section: Patient Cohortmentioning

confidence: 99%

“…Priority was given to OAR dose constraints over PTV coverage for boost plans. More details on the cumulative plan acceptance criteria can be found in Gugliandolo et al (8).…”

Section: Target Definition and Treatment Planningmentioning

confidence: 99%

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Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

et al. 2021

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Rectum and bladder volumes play an important role in the dose distribution reproducibility in prostate cancer adenocarcinoma (PCa) radiotherapy, especially for particle therapy, where density variation can strongly affect the dose distribution. We investigated the reliability and reproducibility of our image-guided radiotherapy (IGRT) and treatment planning protocol for carbon ion radiotherapy (CIRT) within the phase II mixed beam study (AIRC IG 14300) for the treatment of high-risk PCa. In order to calculate the daily dose distribution, a set of synthetic computed tomography (sCT) images was generated from the cone beam computed tomography (CBCT) images acquired in each treatment session. Planning target volume (PTV) together with rectum and bladder volume variation was evaluated with sCT dose-volume histogram (DVH) metric deviations from the planning values. The correlations between the bladder and rectum volumes, and the corresponding DVH metrics, were also assessed. No significant difference in the bladder, rectum, and PTV median volumes between the planning computed tomography (pCT) and the sCT was found. In addition, no significant difference was assessed when comparing the average DVHs and median DVH metrics between pCT and sCT. Dose deviations determined by bladder and rectum filling variations demonstrated that dose distributions were reproducible in terms of both target coverage and organs at risk (OARs) sparing.

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Section: Methodsmentioning

confidence: 99%

Section: Patient Cohortmentioning

confidence: 99%

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Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

et al. 2021

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“…Computed tomography (CT) simulation, volumes of interest contouring, and treatment delivery were performed following the previously described methodology ( 15 , 16 ).…”

Section: Methodsmentioning

confidence: 99%

Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300

et al. 2021

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PurposeThis study represents a descriptive analysis of preliminary results of a Phase II trial on a novel mixed beam radiotherapy (RT) approach, consisting of carbon ions RT (CIRT) followed by intensity-modulated photon RT, in combination with hormonal therapy, for high-risk prostate cancer (HR PCa) with a special focus on acute toxicity.MethodsPrimary endpoint was the evaluation of safety in terms of acute toxicity. Secondary endpoints were early and long-term tolerability of treatment, quality of life (QoL), and efficacy. Data on acute and late toxicities were collected according to RTOG/EORTC. QoL of enrolled patients was assessed by IPSS, EORTC QLQ-C30, EORTC QLQ-PR25, and sexual activity by IIEF-5.ResultsTwenty-six patients were enrolled in the study, but only 15 completed so far the RT course and were included. Immediately after CIRT, no patients experienced GI/GU toxicity. At 1 and 3 months from the whole course RT completion, no GI/GU toxicities greater than grade 2 were observed. QoL scores were overall satisfactory.ConclusionsThe feasibility of the proposed mixed treatment schedule was assessed, and an excellent acute toxicity profile was recorded. Such findings instil confidence in the continuation of this mixed approach, with evaluation of long-term tolerability and efficacy.

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Prostate cancer invading rectal serosa and anal sphincter treated with definitive radiation therapy: Case report and review of the literature

Lee

2023

Journal of Cancer Research and Therapeutics

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Despite anatomical proximity, prostatic adenocarcinoma with rectal invasion is rare. We describe a case of prostate cancer invading the anal sphincter, treated with radiation therapy (RT). A 78-year-old patient underwent definitive radiotherapy in 2018 because of poorly differentiated adenocarcinoma, Gleason 4 + 3 (7). The initial stage was mrT4N0 on magnetic resonance imaging (MRI) images. The pre-treatment prostate-specific antigen level was 142 ng/mL, and the patient was subjected to androgen deprivation therapy. RT was performed using volumetric modulated arc therapy (VMAT) and a dose of 76 Gy in 38 fractions. After 2 months, MRI showed a complete response. During RT, toxicity was limited to mild gastro-intestinal and urologic symptoms. This report is the first to describe prostate cancer invasion of the anal sphincter and to extend to that condition the use of RT – already regarded as a useful treatment option for inoperable locally advanced high-risk prostate cancer (PC). This study suggests that VMAT can be a safe and effective treatment option for locally advanced high-risk PC patients.

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Mixed-beam approach for high-risk prostate cancer: Carbon-ion boost followed by photon intensity-modulated radiotherapy. Dosimetric and geometric evaluations (AIRC IG-14300)

Cited by 3 publications

References 36 publications

Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

Dosimetric Impact of Inter-Fraction Anatomical Changes in Carbon Ion Boost Treatment for High-Risk Prostate Cancer (AIRC IG 14300)

Mixed-Beam Approach for High-Risk Prostate Cancer Carbon-Ion Boost Followed by Photon Intensity-Modulated Radiotherapy: Preliminary Results of Phase II Trial AIRC-IG-14300

Prostate cancer invading rectal serosa and anal sphincter treated with definitive radiation therapy: Case report and review of the literature

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