Mixed Arterial and Venous Thromboembolism in a Person with HIV Infection

Callens, Steven; Florence, Éric; Philippe, Marc; Planken, Marc van der; Colebunders, Robert

doi:10.1080/00365540310017014

Cited by 12 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Available data on the actual prevalence of venous and arterial thromboembolic disease in HIV patients, however, are rather inconclusive. Indeed, most of the published studies are actually case reports or noncontrolled, retrospective cohort studies [7][8][9], and the results of controlled studies are conflicting [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 94%

Venous and arterial thrombosis in patients with HIV infection

Micieli

Dentali²,

Giola³

et al. 2007

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

Thromboembolic complications in HIV-infected patients have been reported. To our knowledge, no case-control studies have compared the prevalence of thromboembolic events between HIV-positive and HIV-negative individuals. One hundred and sixty-nine HIV-infected patients and 180 randomly selected blood donors were enrolled. Selected patients completed a specific questionnaire and were subsequently interviewed. Information was collected on family and personal history of cardiovascular disorders and the presence of personal risk factors for venous and arterial thrombosis. All reported events were adjudicated only if adequate documentation of objective tests was available. Mean age and sex were similar in the two groups. A vascular event was documented in six HIV-infected patients (3.55%) and in none of the controls (P=0.0108). Family history of cardiovascular disorders, cigarette smoking and hypertriglyceridemia were more prevalent in HIV patients than in controls. In multivariate analysis, neither family traditional cardiovascular risk factors nor HIV infection were independently associated with the presence of thromboembolic events. The results confirm the hypothesis that HIV-positive patients have an increased risk of thromboembolic disorders. Whether this increased risk has been provoked by HIV infection itself or by other associated risk factors for cardiovascular events, such as cigarette smoking and hypertriglyceridemia, remain to be clarified.

show abstract

Section: Introductionmentioning

confidence: 94%

Venous and arterial thrombosis in patients with HIV infection

Micieli

Dentali²,

Giola³

et al. 2007

Blood Coagulation &Amp; Fibrinolysis

View full text Add to dashboard Cite

show abstract

“…19-7.63%/year, with most reports citing 1-2%. 6,[9][10][11][12][13][14][15][16][17][18][19][20] This frequency has been correlated to an approximate 10-fold increase in the risk for VTE in the HIV population compared with the general population. 8 The diagnosis of VTE in these studies was generally through International Classification of Disease, Ninth Revision codes, venous duplex ultrasonography, abdominal computed tomography (CT), ventilation-perfusion lung scans, or CT pulmonary angiography.…”

mentioning

confidence: 99%

Risk Factors for Venous Thromboembolism in Patients with Human Immunodeficiency Virus Infection

Kiser

Badowski

2010

Pharmacotherapy

View full text Add to dashboard Cite

Prevention and treatment of venous thromboembolism are gaining attention in the lay and medical communities because of an increase in frequency, cost, and risk factors. Evidence shows that patients with human immunodeficiency virus (HIV) have multiple risk factors and a 2-10-fold increased risk for venous thromboembolism compared with the general population. A higher rate of venous thromboembolism also occurs in patients with HIV who are younger than 50 years (3.31% vs 0.53% in age-matched healthy controls, p<0.0001), have a CD4(+) cell count less than 200 cells/mm³, or have a diagnosis of acquired immunodeficiency syndrome. Both protein S and C deficiencies--disorders that may predispose individuals to thrombotic disease--are considered risk factors; in addition, the use of protease inhibitors and the presence of active opportunistic infections or antiphospholipid antibodies may be associated with venous thromboembolism. It is imperative that all risk factors for venous thromboembolism be identified and incorporated into medical decision making for high-risk patients, including those with HIV. The classification and mechanism of these risk factors are not well understood. Long-term, prospective studies assessing the factors associated with venous thromboembolism in patients with HIV are needed. Risk stratification systems or screening tools, as well as effective preventive measures, must be developed.

show abstract

“…Thrombotic microangiopathy is a well known complication in the advanced phases of HIV-infection and in association with specific conditions [8] and thrombosis has been observed in HIV-infected patients [3,5,10,12]. However, against that argument, our patient had no obvious triggering cause and a normal CD4+ count.…”

mentioning

confidence: 80%

“…We speculate whether the infection by the retrovirus itself might have been the critical prothrombotic component in our patient. In accordance with this, several prothrombogenic factors have been identified in HIV-infected patients [3,5].…”

mentioning

confidence: 81%

“…Besides inflammatory and neoplastic diseases [1], vascular processes should be considered. Hemostasis disturbances and thrombotic microangiopathy have been described in HIV-infected patients [5,6,8] and venous or arterial thrombosis have been observed in HIV-infected patients [3,10]. To the best of our knowledge, internal carotid artery (ICA) thrombosis has not yet been described in HIVpositive patients in the absence of other major thrombophilic factors.…”

mentioning

confidence: 99%

See 1 more Smart Citation