Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer

Mendoza, Rachelle; Haidary, Tahmineh; Gabutan, Elmer; Zhou, Ying; Bukhari, Zaheer; Connelly, Courtney; Lee, Wen-Ching; Lee, Yi-Chun; Wadgaonkar, Raj; Agrawal, Raag; Haseeb, Muhammad; Gupta, Raavi

doi:10.1038/s41598-021-93485-1

Cited by 13 publications

(8 citation statements)

References 52 publications

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“…CC is one of the most serious female reproductive system tumors, which is characterized by high incidence and mortality. Women of all ages are susceptible to CC, especially the middle-aged, seriously affecting their psychological health and social activities [ 12 ]. With the rapid economic and social development and the change of people's living habits, the exposure factors of CC are increasing day by day [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Lin

Wang

2022

Computational and Mathematical Methods in Medicine

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Background. Cervical carcinoma (CC) is a common and highly malignant tumor in women. The involvement of zinc finger E-box binding homeobox 1 (ZEB1) in many kinds of tumors has been well-documented; however, its role and mechanism in CC remain to be clarified. Objective. This study investigated the mechanism of ZEB1 in modulating the growth and metastasis of CC cells. Methods. The expression of ZEB1 in CC tissues and adjacent normal counterparts was determined by reverse transcription-polymerase chain reaction (RT-PCR). The correlation between ZEB1 and patient clinicopathological indexes was analyzed. In vitro, gain and loss functions of ZEB1 were performed in C-33A and HeLa cell lines. The proliferation, migration, and invasion of CC cells were detected by Cell Counting Kit-8 (CCK-8) assay and transwell assay, respectively. The expression levels of apoptosis-related proteins such as BCL2-associated X (Bax), B-cell lymphoma-2 (Bcl2), and Caspase-3, as well as epithelial-mesenchymal transition (EMT)-associated proteins including E-cadherin, Vimentin, and Snail, were measured by Western blotting. In addition, the targeting relationship between ZEB1 and programmed death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) was predicted by bioinformatics and further verified by dual-luciferase reporter assay. Results. ZEB1 was significantly up-regulated in CC tissues compared with normal counterparts. ZEB1 overexpression promoted the migration, proliferation, and invasion of CC cells and inhibited apoptosis, while knocking down ZEB1 contributed to the opposite effects. In addition, experiments on related mechanisms confirmed that ZEB1 targeted the 3’EUTR terminal of PD-1/PD-L1 and negatively regulated its expression. And an interaction between ZEB1 and PD-1/PD-L1 was identified. Conclusion. ZEB1 can promote the proliferation and metastasis of CC cells via modulating the PD-1/PD-L1 checkpoint.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Lin

Wang

2022

Computational and Mathematical Methods in Medicine

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“…While some of the reasons for disparities are linked to cultural, socioeconomic, and genetic factors 41 , studies adjusted for those factors revealed a potential biological bias of higher mortality in this population 42 . We have identified one comparable study by Mendoza et al 43 with a similar population cohort, including 90% of AA women. Their study showed high PD-L1-positivity in AA women with CSCC (93.3%).…”

Section: Discussionmentioning

confidence: 92%

Programmed Death Ligand-1 (PD-L1) Expression in Cervical Squamous Cell Carcinoma: Does it Correlate With Outcomes?

Monsrud

Avadhani

Mošunjac

et al. 2023

International Journal of Gynecological Pathology

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Cervical cancer is one of the most common gynecological malignancies. Upregulation of programmed death ligand-1 (PD-L1), an immunoregulatory protein, is associated with an adverse outcomes in several malignancies. Most studies evaluating PD-L1 expression in cervical squamous cell carcinoma (CSCC) lack data on outcomes. In this study, we correlate PD-L1 expression with clinicopathologic factors and clinical outcomes in invasive CSCC. Seventy-three cases of CSCC from 2010 to 2018 were immunostained for PD-L1. A combined positive score (CPS) of ≥1 and ≥10 was correlated with age, stage, and survival outcomes. Kaplan-Meier curves for progression-free survival and overall survival were plotted and compared using the log-rank test. Cox regression analysis was performed to identify significant prognostic factors (2-tailed P<0.05 was considered statistically significant). With CPS ≥1 or ≥10 as the cut-off, PD-L1 was positive in 52/73 (71.2%) and 23/73 (31.5%) of cases, respectively. PD-L1 positive patients present at a higher stage of disease, especially those with CPS ≥10. With CPS of ≥10 as the cut-off, the 5-yr progression-free survival and 5-yr overall survival were significantly lower (P = 0.034 and 0.012, respectively). Only stage was statistically significant for worse overall survival on multivariate analysis. PD-L1 positive patients present at a higher stage of disease, and stage is an independent prognostic indicator for adverse outcomes in CSCC. This study highlights the potential of PD-L1 targeted therapy in patients with CSCC.

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“…Except for Hispanic patients, historically marginalised racial/ethnic groups had disproportionately lower rates of vaccination and decreased knowledge of HPV (online supplemental table 2). Additionally, these populations had lower physician recommendation for vaccination,20–22 higher prevalence of HPV infections23–32 and were less likely to undergo primary surgery as treatment for HPV-associated cancer 33–35. Although vaccination rates among Hispanic patients were relatively high, all historically marginalised racial/ethnic populations had higher rates of HPV-associated cancer36 and worse cancer-related outcomes compared with white patients 37…”

Section: Resultsmentioning

confidence: 99%

Health inequities in human papillomavirus prevention, diagnostics and clinical care in the USA: a scoping review

et al. 2022

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BackgroundHuman papillomavirus (HPV) represents the most common STI in the USA. HPV inequities in prevention, diagnostics and clinical care persist. We define inequities as systematic, avoidable and unfair differences in health outcomes.ObjectivesThe objectives of this scoping review are to chart existing data on HPV-related inequities, identify gaps in existing literature and guide future research to reduce these inequities.MethodsWe completed a scoping review following guidelines from the Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses scoping reviews extension. We performed a literature search on PubMed and Ovid Embase in July 2022 for articles pertaining to HPV and evaluating populations within the USA. We included English language publications from 2018 to 2022 evaluating at least one health inequity outlined by the National Institutes of Health. General publication characteristics and health inequity data were charted in a masked, duplicate fashion using a pilot-tested Google Form. We analysed frequencies of health inequities and summarised main findings from included studies.ResultsOur final sample included 170 publications. The most common inequities examined were race/ethnicity (140 studies), sex or gender (97 studies), and income (69 studies). Many historically marginalised racial/ethnic groups had lower rates of HPV-related knowledge, vaccination and worse overall outcomes related to HPV. Compared with women, men had lower rates of HPV vaccination and provider recommendation, and higher rates of HPV-infection. Results regarding income were largely conflicting.ConclusionFindings from our review demonstrate clear gaps in HPV-related inequity research. Vaccine completion, provider recommendation and intersectionality should continue to be evaluated to implement targeted interventions.

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Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer

Cited by 13 publications

References 52 publications

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Programmed Death Ligand-1 (PD-L1) Expression in Cervical Squamous Cell Carcinoma: Does it Correlate With Outcomes?

Health inequities in human papillomavirus prevention, diagnostics and clinical care in the USA: a scoping review

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