Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review

Yoshimachi, Shingo; Ohtsuka, Hideo; Aoki, Takeshi; Miura, Takayuki; Ariake, Kyohei; Masuda, Koichi; Ishida, Masaharu; Mizuma, Masamichi; Hayashi, Hiroki; Nakagawa, Kazuhiko; Morikawa, Takanori; Motoi, Fuyuhiko; Kanno, Atsushi; Masamune, Atsushi; Fujishima, Fumiyoshi; Sasano, Hironobu; Kamei, Takashi; Naitoh, Takeshi; Unno, Michiaki

doi:10.1007/s12328-019-01009-2

Cited by 15 publications

(28 citation statements)

References 21 publications

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“…8 To-date, there have only been a few cases of MANECs located in the ampullary region. 9 In this report we describe the case of a MANEC located in the ampulla of Vater. The purpose of this article is to expand medical knowledge of this rare condition and disseminate information about its detection, diagnosis and effective treatment strategies.…”

Section: Introductionmentioning

confidence: 95%

Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

Liu

Sun

et al. 2020

J Int Med Res

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Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract with both epithelial and neuroendocrine components. We describe a case of a 57-year-old man who presented with yellow sclera and dark urine. Contrast-enhanced computed tomography (CT) showed enlargement of the intra and extrahepatic bile ducts and a neoplastic lesion at the end of the common bile duct which was indistinguishable from the adjacent head of the pancreas and duodenum. A pancreaticoduodenectomy was performed and histopathological examination of resected samples showed that tumour was a complex lesion with adenocarcinoma and neuroendocrine components positive for neuroendocrine markers (chromogranin A and synaptophysin) with a Ki-67 labelling index of 40%. The patient was diagnosed with MANEC in the ampulla of Vater with a neuroendocrine carcinoma component of approximately 70%. Ampullary MANECs are highly aggressive tumours with a high risk for distant metastases and a poor prognosis. Therefore, establishing a standard therapeutic strategy is crucial.

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Section: Introductionmentioning

confidence: 95%

Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

Liu

Sun

et al. 2020

J Int Med Res

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“…Duodenal MiNENs do not show a sex predilection, and the average age at diagnosis is~60 years. 35 Symptoms are generally non-specific, and include pain, weight loss, nausea, and vomiting. In some cases, jaundice has also been observed.…”

Section: S M a L L I N T E S T I N Ementioning

confidence: 99%

“…In some cases, jaundice has also been observed. 35 Macroscopically, ampullary MiNEN resembles an adenocarcinoma presenting as a fungating or ulcerated lesion with a mean diameter of 27 mm. Histologically, most cases are composed of adenocarcinoma and NEC, either of the small-cell or the large-cell subtype.…”

Section: S M a L L I N T E S T I N Ementioning

confidence: 99%

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Looking into digestive mixed neuroendocrine – nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors

Uccella

Rosa

2020

Histopathology

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Looking into digestive mixed neuroendocrinenonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors Mixed neuroendocrinenonneuroendocrine neoplasms (MiNENs) of the digestive system represent a challenge for both pathologists and clinicians. Their nomenclature has changed several times, and their diagnostic criteria, classification and clinical behaviour have been matter of debate over the years. Although several attempts have been made to elucidate the pathogenesis and biology of MiNENs, some issues remain open. This review will provide: a historical background that helps in understanding the evolution of the concept and nomenclature of mixed neoplasms; a revision of the knowledge on this topic, including molecular aspects, to give the reader a comprehensive and practical overview on this challenging field of pathology; a focus on the diagnostic criteria and on the determination of prognostic and predictive factors; and a description of the different tumour types in the different sites of origin.

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“…Some ampullary NECs are associated with an adenocarcinoma component (Nassar et al 2005;Yoshimachi et al 2020). When both the neuroendocrine and exocrine components are morphologically recognizable and account for at least 30% of the neoplastic population, the neoplasm is to be classified as mixed neuroendocrine/nonneuroendocrine component (MiNEN) (Fig.…”

Section: Microscopymentioning

confidence: 99%

Duodenal Neuroendocrine Neoplasm

Vanoli¹

2020

Encyclopedia of Pathology

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Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review

Cited by 15 publications

References 21 publications

Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

Mixed adenoneuroendocrine carcinoma (MANEC) of the ampulla of Vater in a Chinese patient: A case report

Looking into digestive mixed neuroendocrine – nonneuroendocrine neoplasms: subtypes, prognosis, and predictive factors

Duodenal Neuroendocrine Neoplasm

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