Mitteilungen der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung

Trappe, H.-J.; Löllgen, H

doi:10.1007/s003920070190

Cited by 78 publications

(5 citation statements)

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“…The German Spiroergometry guidelines were applied for Spiroergometry [ 74 ]. Mechanography was done according to Novotec ® handbook instructions [ 75 , 76 ].…”

Section: Methodsmentioning

confidence: 99%

Immunological Effects of an Add-On Physical Exercise Therapy in Depressed Adolescents and Its Interplay with Depression Severity

Wunram

Oberste

Hamacher

et al. 2021

IJERPH

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Background: Pro-inflammatory cytokines (PICs) have gained attention in the pathophysiology and treatment of depressive disorders. At the same time, the therapeutic effect of physical activity seems to work via immunomodulatory pathways. The interventional study “Mood Vibes” analyzed the influence of exercise on depression severity (primary endpoint) in depressive adolescents; the influence of PICs on the clinical outcome was analyzed as a secondary endpoint. Methods: Clinically diagnosed depressed adolescents (N = 64; 28.1% male; mean age = 15.9; mean BMI = 24.6) were included and participated either in Whole Body Vibration (WBV) (n = 21) or bicycle ergometer training (n = 20) in addition to treatment-as-usual (TAU). Patients in the control treatment group received TAU only (n = 23). The PICs (interleukin-6—IL-6 and tumor necrosis factor-α—TNF-α) were analyzed before intervention, after 6 weeks of training (t1), and 8 weeks post-intervention (t2). The effects of the treatment on depression severity were rated by self-rating “Depression Inventory for Children and Adolescents” (DIKJ). Results: Basal IL-6 decreased in all groups from t0 to t1, but it increased again in WBV and controls at t2. TNF-α diminished in ergometer and controls from baseline to t1. PIC levels showed no correlation with depression severity at baseline. The influence on DIKJ scores over time was significant for IL-6 in the WBV group (p = 0.008). Sex had an impact on TNF-α (p < 0.001), with higher concentrations in male patients. Higher body mass index was associated with higher IL-6 concentrations over all measurement points (p < 0.001). Conclusions: The positive effects of an intensive add-on exercise therapy on adolescent depression seem to be partly influenced by immunomodulation. A small sample size and non-randomized controls are limitations of this study.

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“…The German Spiroergometry guidelines were applied for Spiroergometry [ 74 ]. Mechanography was done according to Novotec ® handbook instructions [ 75 , 76 ].…”

Section: Methodsmentioning

confidence: 99%

Immunological Effects of an Add-On Physical Exercise Therapy in Depressed Adolescents and Its Interplay with Depression Severity

Wunram

Oberste

Hamacher

et al. 2021

IJERPH

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“…After physical examination and a 30-minute period of rest, a needle was inserted in an anticubital vein and all included subjects had to undergo a 12-lead-ECG-controlled graded bicycle exercise test according to the ergometry protocol of the Austrian Society of Cardiology which is consistent with the protocol of the The German Society of Cardiology and the Bruce Protocol [21]. The participants were asked to reach their individual maximum workload (calculated by age, sex, height and weight) until exhaustion occured, where the workload increased every 2 minutes by 25 watts.…”

Section: Methodsmentioning

confidence: 99%

Exercise increases serum endostatin levels in female and male patients with diabetes and controls

Sponder

Dangl

Kampf

et al. 2014

Cardiovasc Diabetol

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Background: Type 2 diabetes mellitus (T2DM) is often associated with atherosclerotic changes in coronary vessels, most notably plaques. The angiostatic parameter endostatin is able to inhibit angiogenesis in tissue as well as in plaques and therefore plays an important role in physiological and pathological neovascularisation. The aim of the present study was to investigate sex-specific differences and the influence of exercise on circulating endostatin levels in patients suffering from diabetes, and control subjects. Methods: In total, 42 T2DM-patients and 45 control subjects were investigated. They underwent a graded physical stress test (ergometry). Serum endostatin levels were measured in venous blood at rest and directly after reaching maximum workload. Results: Females showed significantly higher endostatin levels at baseline measurements compared to men, independently of their underlying disease. In both female and male T2DM-patients endostatin levels were significantly lower compared to controls. Both groups and sexes showed a significant increase of endostatin after physical stress, whereas the extent of endostatin-increase was between 10.59-15.05%.

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“…The exercise capacity in metabolic equivalents (METs) was estimated based on patients body weight and maximum achieved level of exercise on the cycle ergometer in Watts [18]. The Duke Treadmill Score (DTS) was calculated based on the METs, the amount of ST-segment deviation, and exercise angina index [12,19].…”

Section: Methodsmentioning

confidence: 99%

Comparison of exercise electrocardiography and stress perfusion CMR for the detection of coronary artery disease in women

Greulich

Bruder

Parker

et al. 2012

Journal of Cardiovascular Magnetic Resonance

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BackgroundExercise electrocardiography (ECG) is frequently used in the work-up of patients with suspected coronary artery disease (CAD), however the accuracy is reduced in women. Cardiovascular magnetic resonance (CMR) stress testing can accurately diagnose CAD in women. To date, a direct comparison of CMR to ECG has not been performed.Methods and resultsWe prospectively enrolled 88 consecutive women with chest pain or other symptoms suggestive of CAD. Patients underwent a comprehensive clinical evaluation, exercise ECG, a CMR stress test including perfusion and infarct imaging, and x-ray coronary angiography (CA) within 24 hours. CAD was defined as stenosis ≥70% on quantitative analysis of CA.Exercise ECG, CMR and CA was completed in 68 females (age 66.4 ± 8.8 years, number of CAD risk factors 3.5 ± 1.4). The prevalence of CAD on CA was 29%. The Duke treadmill score (DTS) in the entire group was −3.0 ± 5.4 and was similar in those with and without CAD (−4.5 ± 5.8 and −2.4 ± 5.1; P = 0.12). Sensitivity, specificity and accuracy for CAD diagnosis was higher for CMR compared with exercise ECG (sensitivities 85% and 50%, P = 0.02, specificities 94% and 73%, P = 0.01, and accuracies 91% and 66%, P = 0.0007, respectively). Even after applying the DTS the accuracy of CMR was higher compared to exercise ECG (area under ROC curve 0.94 ± 0.03 vs 0.56 ± 0.07; P = 0.0001).ConclusionsIn women with intermediate-to-high risk for CAD who are able to exercise and have interpretable resting ECG, CMR stress perfusion imaging has higher accuracy for the detection of relevant obstruction of the epicardial coronaries when directly compared to exercise ECG.

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Mitteilungen der Deutschen Gesellschaft für Kardiologie – Herz- und Kreislaufforschung

Cited by 78 publications

References 0 publications

Immunological Effects of an Add-On Physical Exercise Therapy in Depressed Adolescents and Its Interplay with Depression Severity

Immunological Effects of an Add-On Physical Exercise Therapy in Depressed Adolescents and Its Interplay with Depression Severity

Exercise increases serum endostatin levels in female and male patients with diabetes and controls

Comparison of exercise electrocardiography and stress perfusion CMR for the detection of coronary artery disease in women

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