Mitral valve replacement with glutaraldehyde preserved aortic allografts1

Salles, Cláudio A; Buffolo, Ênio; Andrade, José Carlos S; Palma, José Honório; Silva, R. R. P.; Santiago, Roberto; Casagrande, Ivan S. J.; Moreira, M.C.V.

doi:10.1016/s1010-7940(97)00320-5

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Finally, for full clinical translational use of this approach one must consider issues related to potential toxicities of the crosslinking agent used in this study. While GLUT is utilized for preservation of implant biologic materials, such as valves, cartilage, and tendons [25,[68][69][70], there have been many studies that reported information regarding cytotoxicity and immunogenicity of using GLUT as a crosslinking agent in the literature [71][72][73][74]. Most of these studies do not discuss the in vivo responses due to the presence of biopolymer grafts crosslinked with GLUT vapor.…”

Section: Discussionmentioning

confidence: 99%

“…Small-diameter synthetic polymer grafts, which introduce an exogenous nonbiological material into the body, have been shown to be biocompatible and/ or biodegradable in some small animal models [15][16][17][18][19][20] but may not be suitable for some large animal models [21,22] and clinical patients [3,23,24], due to acute thrombogenicity and anastomotic intimal hyperplasia. While some researchers have attempted to address this issue by reducing the thrombogenetic nature of the synthetic polymer [8,25], others have considered nonsynthetic biopolymers to fabricate their scaffolds [26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries

Tamimi

Ardila

Haskett

et al. 2015

Journal of Biomechanical Engineering

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Cardiovascular disease (CVD) is the leading cause of death for Americans. As coronary artery bypass graft surgery (CABG) remains a mainstay of therapy for CVD and native vein grafts are limited by issues of supply and lifespan, an effective readily available tissue-engineered vascular graft (TEVG) for use in CABG would provide drastic improvements in patient care. Biomechanical mismatch between vascular grafts and native vasculature has been shown to be the major cause of graft failure, and therefore, there is need for compliance-matched biocompatible TEVGs for clinical implantation. The current study investigates the biaxial mechanical characterization of acellular electrospun glutaraldehyde (GLUT) vapor-crosslinked gelatin/fibrinogen cylindrical constructs, using a custom-made microbiaxial optomechanical device (MOD). Constructs crosslinked for 2, 8, and 24 hrs are compared to mechanically characterized porcine left anterior descending coronary (LADC) artery. The mechanical response data were used for constitutive modeling using a modified Fung strain energy equation. The results showed that constructs crosslinked for 2 and 8 hrs exhibited circumferential and axial tangential moduli (ATM) similar to that of the LADC. Furthermore, the 8-hrs experimental group was the only one to compliance-match the LADC, with compliance values of 0.0006±0.00018 mm Hg-1 and 0.00071±0.00027 mm Hg-1, respectively. The results of this study show the feasibility of meeting mechanical specifications expected of native arteries through manipulating GLUT vapor crosslinking time. The comprehensive mechanical characterization of cylindrical biopolymer constructs in this study is an important first step to successfully develop a biopolymer compliance-matched TEVG.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomechanical Comparison of Glutaraldehyde-Crosslinked Gelatin Fibrinogen Electrospun Scaffolds to Porcine Coronary Arteries

Tamimi

Ardila

Haskett

et al. 2015

Journal of Biomechanical Engineering

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“…While other storage methods such as glutaraldehyde [ 113 ], glycerol [ 114 ], etc., have been reported, there is no consensus so far on the best storage strategies to ensure the quality of decellularized TEHV.…”

Section: Discussionmentioning

confidence: 99%

Tissue Engineered Transcatheter Pulmonary Valved Stent Implantation: Current State and Future Prospect

Zhang

Puehler

Seiler

et al. 2022

IJMS

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Patients with the complex congenital heart disease (CHD) are usually associated with right ventricular outflow tract dysfunction and typically require multiple surgical interventions during their lives to relieve the right ventricular outflow tract abnormality. Transcatheter pulmonary valve replacement was used as a non-surgical, less invasive alternative treatment for right ventricular outflow tract dysfunction and has been rapidly developing over the past years. Despite the current favorable results of transcatheter pulmonary valve replacement, many patients eligible for pulmonary valve replacement are still not candidates for transcatheter pulmonary valve replacement. Therefore, one of the significant future challenges is to expand transcatheter pulmonary valve replacement to a broader patient population. This review describes the limitations and problems of existing techniques and focuses on decellularized tissue engineering for pulmonary valve stenting.

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