Mitral valve repair or replacement for ischemic mitral regurgitation? The Italian Study on the Treatment of Ischemic Mitral Regurgitation (ISTIMIR)

Lorusso, Roberto; Gelsomino, Sandro; Vizzardi, Enrico; D’Aloia, Antonio; Cicco, Giuseppe De; Lucà, Fabiana; Parise, Orlando; Gensini, Gian Franco; Stefàno, Pierluigi; Livi, Ugolino; Vendramin, Igor; Pacini, Davide; Bartolomeo, Roberto Di; Miceli, Antonio; Varone, Egidio; Glauber, Mattia; Parolari, Alessandro; Arlati, Francesco; Alamanni, Francesco; Serraino, Giuseppe Filiberto; Renzulli, Attilio; Messina, Antonio; Troise, Giovanni; Mariscalco, Giovanni; Cottini, Marzia; Beghi, Cesare; Nicolini, Francesco; Gherli, Tiziano; Borghetti, Valentino; Pardini, Alessandro; Caimmi, Philippe Primo; Micalizzi, Ezio; Fino, Carlo; Ferrazzi, Paolo; Mauro, Michele Di; Calafiore, Antonio M.

doi:10.1016/j.jtcvs.2012.09.042

Cited by 112 publications

(94 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13,14) Although the reoperation ratios are suggested to be similar, there are studies referring to high reoperation ratios in the ischemic mitral regurgitation. 7) None of our patients needed reoperation within the six-month follow-up. In a cost-analysis study, it is suggested that repair can be the first choice with its lower cost comparing to the replacement applied with mechanical or biological valve.…”

Section: Discussionmentioning

confidence: 64%

“…3,4) Although thromboembolic complications in the mechanical valves and early degeneration of biological valves were the major disadvantages of mitral valve replacement (MVR), due to the high achievement drive of the method in terms of early post-surgical rehabilitation, it was used as the preferred method in the mitral valve surgery for many years. [5][6][7] However, during the last ten years, thanks to the better standardized rehabilitation techniques, surgeons gained experience and in this way mitral valve repair (MvRp) has become the preferred method in mitral valve surgery. 5,6) The success of the mitral operations has increased due to the standardization of surgical techniques and comprehensive post-operative intensive care.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Health Related Quality of Life of Patients Following Mitral Valve Surgical Procedures in the 6-Months Follow-up: A Prospective Study

Kara

Aydın

et al. 2013

ATCS

View full text Add to dashboard Cite

Purpose: The aim of the present study is to evaluate the health-related quality of life of the patients who underwent mitral valve repair (MvRp) and mitral valve replacement (MVR). Methods: Within the scope of this prospective study design, 56 patients who had mitral valve operation between the years of 2011-2012 were enrolled in the study. 24 (42.8%) of these patients had MVR while 32 (57.1%) of them had MvRp. The health-related quality of life was evaluated according to the Turkey norms of Short Form 36 Quality-Of-Life Measures (SF-36), which were filled in by the patients before and 6 months after the operation. Moreover, preoperative risk factors affecting the quality of life (age, gender, functional capacity, rhythm, hypertension, diabetes, applied surgical method and echocardiographic results) were investigated for all the patients (n = 56) by using independent sample t test analysis. Results: When the pre and postoperative changes were compared between the two groups, it was found out that there were no significant difference between the groups in terms of restraints on physical role functioning (PR), and the social role functioning values (SF) (respectively; p = 0.097, p = 0.105). However, in the comparison of pre-/postoperative changes between the groups, the changes in physical functioning (PF), bodily pain (BP), general health (GH), vitality (VT) and restraints on emotional role functioning (RE) and mental health (MH) values were found out to be significantly superior in the MvRp group than in the MVR group (respectively; p <0.01, p <0.05, p <0.01, p <0.01, p <0.05 and p <0.01). It was also confirmed that female gender, atrial fibrillation (AFR), and MVR method negatively affected the physical and mental components (respectively; p = 0.033, p = 0.003, p = 0.015). Conclusion: Results of the SF-36 quality of life measures show that quality of life may be better in patients that have had MvRp. It should be considered that the planned surgical treatment method can affect the patient's quality of life, and this effect can indicate the success of the surgical treatment.

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Comparison of the Health Related Quality of Life of Patients Following Mitral Valve Surgical Procedures in the 6-Months Follow-up: A Prospective Study

Kara

Aydın

et al. 2013

ATCS

View full text Add to dashboard Cite

show abstract

“…From the initial cohort of 257 patients, 143 were excluded for various reasons [9], i.e., 1) Presence of aortic valve regurgitation or stenosis, congenital valvular heart disease, infective endocarditis, or recurrent MR (i.e., postoperative MR ≥ 2+ at follow-up); or 2) Performance of other procedures, such as LV reconstruction/reshaping, partial band/pericardial annuloplasty, or procedures other than ring annuloplasty for mitral valve plasty. Thus, the final study cohort was comprised of 114 patients.…”

Section: Patients and Study Designmentioning

confidence: 99%

“…eligible for inclusion in the study. CIMR was defined by echocardiographic and coronary angiographic findings according to accepted criteria, i.e., 1) MR occurring more than 16 days after myocardial infarction; 2) ≥ 70% stenosis of at least one coronary artery, with wall motion abnormalities of the corresponding left ventricular (LV) segment; and 3) Type I/IIIb leaflet dysfunction according to the Carpentier classification [9].…”

Section: Introductionmentioning

confidence: 99%

Predicting functional mitral stenosis after restrictive annuloplasty for ischemic mitral regurgitation

Sun

et al. 2019

Cardiol J

View full text Add to dashboard Cite

show abstract

“…48 This tech nique can be recommended in patients with severe mitral valve tethering (coaptation distance >1 cm) in secondary MR, where it is likely to produce similar survival rates and less recurrent MR than mitral valve repair. 49 …”

Section: Surgical Optionsmentioning

confidence: 99%

Therapeutic decision-making for patients with fluctuating mitral regurgitation

2015

View full text Add to dashboard Cite

| Mitral regurgitation (MR) is a common, progressive, and difficult-to-manage disease. MR is dynamic in nature, with physiological fluctuations occurring in response to various stimuli such as exercise and ischaemia, which can precipitate the development of symptoms and subsequent cardiac events. In both chronic primary and secondary MR, the dynamic behaviour of MR can be reliably examined during stress echocardiography. Dynamic fluctuation of MR can also have prognostic value; patients with a marked increase in regurgitant volume or who exhibit increased systolic pulmonary artery pressure during exercise have lower symptom-free survival than those who do not experience significant changes in MR and systolic pulmonary artery pressure during exercise. Identifying patients who have dynamic MR, and understanding the mechanisms underlying the condition, can potentially influence revascularization strategies (such as the surgical restoration of coronary blood flow) and interventional treatment (including cardiac resynchronization therapy and new approaches targeted to the mitral valve).

show abstract

Mitral valve repair or replacement for ischemic mitral regurgitation? The Italian Study on the Treatment of Ischemic Mitral Regurgitation (ISTIMIR)

Abstract: Mitral valve replacement is a suitable option for patients with chronic ischemic mitral regurgitation and impaired left ventricular function. It provides better results in terms of freedom from reoperation with comparable valve-related complication rates.

Cited by 112 publications

References 27 publications

Comparison of the Health Related Quality of Life of Patients Following Mitral Valve Surgical Procedures in the 6-Months Follow-up: A Prospective Study

Comparison of the Health Related Quality of Life of Patients Following Mitral Valve Surgical Procedures in the 6-Months Follow-up: A Prospective Study

Predicting functional mitral stenosis after restrictive annuloplasty for ischemic mitral regurgitation

Therapeutic decision-making for patients with fluctuating mitral regurgitation

Contact Info

Product

Resources

About