Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1

The underlying causes of chordae tendinae rupture: A systematic review

“…Degeneration may be either idiopathic or inherited. Previous studies suggested x-linked inheritance or autosomal dominant inheritance [40,41]. MD of the mitral valve is more frequent among males, and with age.…”

Cardiovascular characterization of Pkd2+/LacZ mice, an animal model for the autosomal dominant polycystic kidney disease type 2 (ADPKD2)

“…However, despite the feasibility of subdividing ADPKD patients into genetically defined groups (ADPKD type I caused by mutations in PKD1 versus ADPKD type 2 caused by mutation in PKD2) up to now only a single study has been published comparing a genetically classified cohort of ADPKD type 1 patients to unaffected family members and healthy controls [34]. In addition, although Pkd1 and Pkd2 mouse models are available, there are to the best of our knowledge no published data concerning the question whether cardiac performance is impacted in these animals.…”

Clinical Manifestation, Management and Prognosis of Acute Myocardial Infarction in Autosomal Dominant Polycystic Kidney Disease

“…50% of hypertensive patients with ADPKD exhibit left ventricular hypertrophy (LVH) [10]. Additionally, cardiac valvular abnormalities occur in more than 20% of patients, with defects of the aortic root, annulus, and mitral valve being the predominant irregularities [11]. As one of the most serious complications of ADPKD, AMI must be a topic of greater research focus as it is a cause of mortality in approximately 10% of the world population [12].…”