Mitral valve prolapse

Hayek, Emil; Gring, Christian; Griffin, Brian P.

doi:10.1016/s0140-6736(05)17869-6

Cited by 224 publications

(164 citation statements)

References 141 publications

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“…77 When asymptomatic, this disease is usually discovered incidentally during clinical examination or during an echocardiogram. 74 MVP is more likely to be found in people having thoracic skeletal abnormalities and a leaner build. 76,78 MVP is usually suspected following auscultatory findings, physical examination being a diagnostic standard.…”

Section: 72mentioning

confidence: 97%

“…11,72 It is defined by echocardiography as mono-or bileaflet (or limited only to scallops) systolic atrial displacement of at least 2 mm over the long-axis annular plane, that can be accompanied or not by leaflet thickening. 35,73,74 The disease is characterised by typical fibromyxomatous changes of the leaflet tissue and possibly chordal abnormalities such as lengthening. 37,73 According to the Framingham Heart Study, MVP affects approximately one in 40 individuals, irrespective of sex and age.…”

Section: Mitral Valve Prolapsementioning

confidence: 99%

“…75,76 The early misconception that this syndrome frequently occurs simultaneously with MVP was not confirmed by case-control studies. 35,74 Symptoms occur when the compensatory ventricular dilation is overwhelmed and they indicate severe MR and LV dysfunction. Nonetheless, if the ventricular compensation of the severe MR is appropriate, the patient may remain asymptomatic for many years.…”

Section: Clinical Evaluationmentioning

confidence: 99%

“…75,79 Classically, a dynamic, mid-to-late systolic click commonly associated with a late systolic murmur has been described. 74 However, a late systolic murmur is more frequent than a mid-to-late systolic click. 79 The click-dynamics may be perceived with specific maneuvers: an earlier click is produced by a reduced end-diastolic volume (e.g.…”

Section: 72mentioning

confidence: 99%

“…Valsalva, standing), whereas opposite maneuvers generate a click shift into late systole. 74,80 With chordal rupture and consequent leaflet flail, the murmur becomes holosystolic. A flailing posterior leaflet will generate a murmur radiating anteriorly which may mimic aortic stenosis.…”

Section: 72mentioning

confidence: 99%

See 4 more Smart Citations

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Popa

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Papagheorghe

et al. 2016

Discoveries (Craiova)

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Section: 72mentioning

confidence: 97%

Section: Mitral Valve Prolapsementioning

confidence: 99%

Section: Clinical Evaluationmentioning

confidence: 99%

Section: 72mentioning

confidence: 99%

Section: 72mentioning

confidence: 99%

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The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

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Left Ventricular Inflow Regurgitation

Séguéla

Léobon

Acar

2012

Pediatric Cardiovascular Medicine

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Diagnostic yield in adults screened at the marfan outpatient clinic using the 1996 and 2010 ghent nosologies

Aalberts

Thio

Schuurman

et al. 2012

American J of Med Genetics Pt A

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Marfan syndrome (MFS) is diagnosed according to the Ghent nosology, which has recently been revised. In the Netherlands, evaluation for possible MFS is performed in specialized Marfan outpatient clinics. We investigated the diagnostic yield in our clinic and the impact of the 2010 nosology. All adult patients (n = 343) who visited our clinic between 1998 and 2008 were included. We analyzed their reasons for referral, characteristics, and established diagnoses. In addition, we applied the 2010 nosology to all patients and compared the outcomes to those obtained with the 1996 nosology. Diagnoses that were made using the 1996 and the 2010 Ghent nosology included MFS (44/343 vs. 47/343), familial thoracic aortic aneurysm and/or dissection (22/343 vs. 22/343 patients), Loeys-Dietz syndrome (4/343 vs. 4/343 patients), and (familial) mitral valve prolapse (MVPS; 5/343 vs. 28/343 patients). In both nosologies, 77% of MFS patients had an FBN1 mutation. The 2010 nosology led to an increase in the number of diagnoses made: 4 additional cases of MFS were identified (one patient was "lost" who no longer fulfilled the criteria) and 23 additional cases of MVPS were diagnosed. The diagnostic yield of patients with aortic root dilatation was 65% using the 1996 nosology and 70% using the 2010 nosology. The change in diagnoses did not lead to a difference in clinical follow-up. We conclude that the diagnostic yield of our specialized clinic was high, in particular in patients with aortic root dilatation. Further more the 2010 Ghent nosology led to a significant increase in the number of diagnoses made, mainly due to lowering of the diagnostic threshold for MVPS.

show abstract

Mitral valve prolapse

Cited by 224 publications

References 141 publications

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Left Ventricular Inflow Regurgitation

Diagnostic yield in adults screened at the marfan outpatient clinic using the 1996 and 2010 ghent nosologies

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