Mitral valvar grafts

Ionescu, Marian I.

doi:10.1136/hrt.33.suppl.56

Cited by 6 publications

(2 citation statements)

References 6 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bovine pericardium is an important natural biomaterial for treatment of multiple pathological conditions in the regenerative medicine. Their application range covers cardiac valve reconstruction [11], ophthalmic surgery [12,13], bony and periodontal defects [14,15], gingival recessions [16], reconstruction and closure of blood vessels [17], abdominal wall repair [18]. All scaffolds designed for clinical use that utilize tissues derived from biologic sources must undergo a series of processing steps designed to rid the material of diseases causing agents and provide the sterility required for surgical use [19].…”

Section: Discussionmentioning

confidence: 99%

Biological Membrane with Antimicrobial Activity Based on Lyophilized and Decellularized Bovine Pericardium Impregnated with Vancomycin or Silver Nanoparticles

Collatusso,

Dantas,

Suss

et al. 2023

Preprint

View full text Add to dashboard Cite

Introduction: Infections associated with medical implants pose significant challenges to healthcare, demanding the development of new effective antimicrobial strategies. This study focuses on the creation of a novel biological membrane with enhanced antimicrobial properties by with the incorporation of either vancomycin or silver nanoparticles. Methods: Pericardium samples were impregnated with either silver nanoparticles (AgNPs) or vancomycin (VAN). The antimicrobial activity of the membranes was assessed through qualitative microbiological analysis, biofilm production and animal in vivo model of infection. Histological analysis was performed on the pericardium samples, and quantitative microbiological analysis was conducted on the tissue from the animal model and biocompatibility evaluation. Statistical analyses were carried out using appropriate tests. Results: Microbiological tests confirmed both VAN and AgNP showed inhibition halos against bacteria. Histological analysis indicated minimal inflammatory response and bacterial presence in VAN and AgNP groups compared to the control group revealed reduced bacterial presence. Biomechanical testing showed that polypropylene had the lowest tensile strength, while AgNP-impregnated pericardium exhibited lower resistance than VAN-impregnated and control pericardium. Conclusion: Lyophilized and decellularized bovine pericardium as a substrate, combined with the incorporation of vancomycin or silver nanoparticles, provides a versatile platform for combating infections associated with medical implants.

show abstract

Section: Discussionmentioning

confidence: 99%

Biological Membrane with Antimicrobial Activity Based on Lyophilized and Decellularized Bovine Pericardium Impregnated with Vancomycin or Silver Nanoparticles

Collatusso,

Dantas,

Suss

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The first reported clinical use of bovine pericardium was used in construction of an artificial heart valve in 1971 by Ionescu [14]. Since that time various congenital cardiac defects such as ASD, VSD, and Tetralogy of Fallot have been treated with bovine pericardium as a patch material.…”

Section: Discussionmentioning

confidence: 99%

Polyester vs. Bovine Pericardial Patching during Carotid Endarterectomy: Early Neurologic Events and Incidence of Restenosis

Neuhauser

Oldenburg

2003

Cardiovascular Surgery

View full text Add to dashboard Cite

Purpose The aim of this report was to compare polyester vs. bovine pericardial patching during CEA with regards to the incidence of early neurologic events and recurrent stenosis. Patients and methods One hundred and twenty-five consecutive patients with high grade symptomatic (14%) or asymptomatic (86%) carotid artery stenosis (>70%) who underwent 139 CEAs by a single surgeon between January 1997 and April 2001 were retrospectively reviewed. Patients were assessed postoperatively clinically and with routine follow-up duplex scanning. Recurrent stenosis was defined as a narrowing in the common or internal carotid artery of more than 50% by duplex ultrasound examination. Results From January 1997 to May 1999, a polyester patch was routinely used in 81 (58%) patients, while between June 1999 and April 2001, a bovine pericardium patch was exclusively used in 59 (42%) patients. There were no ipsilateral postoperative TIAs or strokes in either group. The combined 30-day mortality rate for both groups was 0.8%. One patient in the polyester patch group died from cardiopulmonary complications 10 days after discharge. The length of follow-up in the bovine pericardial patch group was 3–28 months (mean 12 months), while in the polyester patch group was 1–50 months (mean 24.5 month). One patient developed a carotid pseudoaneurysm of the suture line in the bovine pericardium patch group caused by a local infection after previous neck dissection and radiation. The incidence of recurrent stenosis was two patients (4%) in the bovine pericardium group as opposed to six patients (7.6%) in the polyester patch group. Conclusion Although this is a preliminary report, it is concluded that bovine pericardium provides excellent perioperative results and is at least comparable to polyester patching in terms of safety. Our study with short term follow up suggests that bovine pericardium patching during carotid endarterectomy may have a lower restenosis rate compared to knitted polyester patching. Clear superiority of bovine pericardium as a patch material awaits a prospective randomised study with long-term follow-up.

show abstract

Biological membrane with antimicrobial activity with vancomycin and silver nanoparticles for guided bone regeneration – Development and clinical study

Collatusso,

Bespalez,

Dantas

et al. 2024

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

Mitral valvar grafts

Cited by 6 publications

References 6 publications

Biological Membrane with Antimicrobial Activity Based on Lyophilized and Decellularized Bovine Pericardium Impregnated with Vancomycin or Silver Nanoparticles

Biological Membrane with Antimicrobial Activity Based on Lyophilized and Decellularized Bovine Pericardium Impregnated with Vancomycin or Silver Nanoparticles

Polyester vs. Bovine Pericardial Patching during Carotid Endarterectomy: Early Neurologic Events and Incidence of Restenosis

Biological membrane with antimicrobial activity with vancomycin and silver nanoparticles for guided bone regeneration – Development and clinical study

Contact Info

Product

Resources

About