Mitral annular calcification as a cause of mitral valve gradients

Diastolic transmitral valve pressure gradients in patients with severe calcific aortic stenosis

“…Mitral annular calcification and aortic valve sclerosis frequently coexist [7][8][9][10][11][12][13][14], and its presence has been shown to be predictive of the progression of aortic sclerosis to aortic stenosis [15]. There are reports of a MVG seen in patients with mitral annular calcification [16,17]. Potential mechanisms include a rigid annulus which fails to dilate during diastole [16] and extension of disease to involve mitral leaflet calcification [17].…”

“…There are reports of a MVG seen in patients with mitral annular calcification [16,17]. Potential mechanisms include a rigid annulus which fails to dilate during diastole [16] and extension of disease to involve mitral leaflet calcification [17]. It is therefore possible that there is a MVG seen in patients with calcific aortic stenosis due to its association with mitral annular calcification.…”

Echocardiographic Assessment of Degenerative Mitral Stenosis: A Diagnostic Challenge of an Emerging Cardiac Disease

“…41 Data from more recent studies utilizing multimodality imaging have demonstrated that involvement of the anterior annulus is not as rare as it was previously thought. A recent retrospective study on patients ≥ 65 years of age assessed the frequency of calcium deposits in different segments of the mitral annulus using non-contrast CT scan images performed for other clinical indications.…”

Degenerative Mitral Stenosis

“…Analysis of 22 patients with moderately or severely reduced anterior mitral leaflet mobility secondary to MAC revealed a mean mitral valve gradient of 7±3 compared with 3±1 mm Hg in 21 patients with normal anterior mitral leaflet mobility. 28 Limited data are available for the natural history of progression of DMS. Tyagi and colleagues 29 studied the progression of DMS in a cohort of 254 patients.…”