Mitragyna inermis Willd (Rubiaceae) inhibits Acetylcholinesterase and Butyrylcholinesterase activities in Alzheimer’s disease mice models.

Abstract

The objective of our study was to evaluate the anti-Alzheimer activities of Mitragyna inermis leaf decoction against scopolamine, D-galactose and atropineinduced Alzheimer likes effects in mice. Mitragyna inermis leaves decoction was used against memory lost, which is characterized in our study by the elevation of acetylcholinesterase and butyrylcholinesterase activities induced by scopolamine, Dgalactose and atropine. For this study, we used behavioral tests such as Elevated Plus maze and Open field tests, and biochemical tests were the determination of AChE and BChE activities. In all tests, mice of 18 to 25 g were divided into groups of 5. The Mitragyna inermis…..