Mitotically active deep juvenile xanthogranuloma

Kořen, Jan; Matecek, Ludovit; Zámečnı́k, Michal

doi:10.1016/j.anndiagpath.2009.09.004

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…The high number of mitoses found in some NJXG cases could be explained by their immature or evolving character [4,9,10]. Nevertheless, two unusual cases of mitotically active classic JXG have been reported [23,24], demonstrating that mitotically active cases are not restricted to NJXG. Kubota et al [12] presented other interesting case of JXG on the scalp of an 8-month-old girl.…”

Section: Discussionmentioning

confidence: 99%

Nonlipidized juvenile xanthogranuloma: An unusual variant with a potential diagnostic pitfall

Batista

Mendonça

Elias

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Nonlipidized juvenile xanthogranuloma: An unusual variant with a potential diagnostic pitfall

Batista

Mendonça

Elias

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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“…To our knowledge, 51 cases of giant JXG have been reported in the English literature. 8,10-50 We analyzed all cases of giant JXG for various characteristics. In our analysis, we also compared giant JXG and classic JXG (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Ladha

Haber

2018

J Cutan Med Surg

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Juvenile xanthogranuloma (JXG) is a member of the non-Langerhans cell group of proliferative disorders of mononuclear phagocytes. JXG is a benign tumour of histiocytic cells. Classic JXG is divided into 2 main clinical subtypes: dome-shaped papules (<0.5 cm) and single/multiple nodules (<2.0 cm). A rare variant is referred to as giant; this term encompasses JXG lesions larger than 2.0 cm. In this article, we report a case of a congenital cutaneous giant JXG. In addition, we reviewed and analyzed all cases (n = 51) of giant JXG reported in the English literature. We propose an algorithm for classifying giant JXG based on the following factors: onset of lesions (congenital and acquired), number of lesions (solitary ± satellites and multiple), morphology of cutaneous/mucosal lesions (plaque, nodular, ulcerated-nodular, macular, and other), and extracutaneous manifestations.

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“…A central rounded to ovoid to a reniform nucleus with or without a nuclear groove is surrounded by a pale amphophilic cytoplasm; more prominent nuclear grooves and eosinophilic cytoplasm are features that give the mononuclear cells of JXG a striking resemblance to LCs. Nuclear atypia and mitotic figures are present in some cases, which can convey an unsettling appearance to the lesion [238]. Eosinophils and lymphocytes may also be prominent.…”

Section: Juvenile Xanthogranulomamentioning

confidence: 99%

Fibrohistiocytic Tumors and Related Neoplasms in Children and Adolescents

2012

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Fibrohistiocytic tumors (FHTs) in children and adolescents range from the benign fibrous histiocytoma, or dermatofibroma, to a variety of intermediate and malignant neoplasms, such as dermatofibrosarcoma protruberans and high-grade undifferentiated pleomorphic sarcoma (malignant fibrous histiocytoma). Those tumors as a group are comprised of fibroblasts, myofibroblasts, and histiocytes-dendritic cells with a variably prominent inflammatory infiltrate consisting of lymphocytes and eosinophils. Dendritic cells are also a major constituent of another group of neoplasms that include Langerhans cell histiocytosis, follicular and interdigitating cell sarcomas, and juvenile xanthogranuloma. These latter tumors are considered in this discussion for the sake of differential diagnosis and their possible histogenetic relationship to FHTs. Recent studies have suggested that the relationship between the fibroblast and histiocyte in the FHTs may reflect the intrinsic capacity to transdifferentiate from one to the other morphologic and functional state. The so-called “facultative fibroblast,” as a cell with fibroblastic and histiocytic properties, was discussed in the context of the fibrous xanthoma 50 years ago. Possibly the entire histogenetic concept of FHTs should be reconsidered in light of current studies.

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Mitotically active deep juvenile xanthogranuloma

Cited by 13 publications

References 20 publications

Nonlipidized juvenile xanthogranuloma: An unusual variant with a potential diagnostic pitfall

Nonlipidized juvenile xanthogranuloma: An unusual variant with a potential diagnostic pitfall

Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification

Fibrohistiocytic Tumors and Related Neoplasms in Children and Adolescents

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