Mitotic Rhythm in Human Epidermis

Cooper, Zola K.

doi:10.1038/jid.1939.25

Cited by 50 publications

(10 citation statements)

References 5 publications

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“…In man, however, scarce and even contradictory results have been published as yet [Cooper and Sell iff, 1938;Cooper, 1939;Broders and Dublin, 1939;Scheving, 1959;Fisher, 1968;Kahn et a i, 1968;Pullmann et a!., 1974;Schell el al., 1977] whereas, in laboratory animals a circadian rhythmicity in epidermal growth which is correlated with phases of bodily resting and activity has been proved [Bullough, 1948a, b;Scheving and Pauly, 1960;Alov, 1963]. In nocturnal animals such as mice and rats, e.g., lowered rates of both epidermal DNA synthesis and mitotic activity have been determined during night alternating with an increase of epidermal proliferation during resting.…”

Section: Discussionmentioning

confidence: 99%

Human Epidermal Cell Proliferation with Regard to Circadian Variation of Plasma Cortisol

Schell¹,

Hornstein²,

Schwarz³

1980

Dermatology

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This study was performed in 6 healthy young men under analogous experimental conditions to investigate whether or not the epidermal proliferative activity is influenced by the physiological circadian rhythmicity of cortisol concentration in blood. Every 6 h of total duration of the experiments, blood samples were taken for radioimmunoassay of serum cortisol and skin punch biopsies (upper arm inside) were labelled in vitro by ³H-thymidine. In 4 out of 6 individuals, an inverse and time-shifted correlation between the combined serum cortisol levels and the epidermal ³H-LI could be found, i.e., a rise or decline of serum cortisol were followed by a lowered or elevated rate of epidermal LI 6 h later. In particular, a steep increase of serum cortisol from midnight to 6 a.m. correlated to a decrease of ³H-LI from 6 a.m. to noon. This indicates that in man the rate of the epidermal proliferative activity inversely depends, apart from other mechanisms of regulation, on the concentration and circadian periodicity of endogenous cortisol in blood. However, we failed to demonstrate a clear circadian rhythm of the epidermal proliferation, possibly due to the short duration of the experiments extended in each individual to 48 h only.

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Section: Discussionmentioning

confidence: 99%

Human Epidermal Cell Proliferation with Regard to Circadian Variation of Plasma Cortisol

Schell¹,

Hornstein²,

Schwarz³

1980

Dermatology

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“…Circadian variation of mitotic activity in normal human tissues has been described since 1938 189 . The uncoupling of mitotic rhythm between normal host tissue and metastasizing cancer was first reported in 1940 190 .…”

Section: The Role Of the Mammalian Circadian Clock In Tumor Suppressionmentioning

confidence: 99%

The Circadian Clock in Cancer Development and Therapy

Kettner

2013

Progress in Molecular Biology and Translational Science

216

198

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Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and peripheral clocks coordinately generate rhythmic gene expression in a tissue-specific manner in vivo to couple diverse physiological and behavioral processes to periodic changes in the environment. However, as the world industrialized, activities that disrupt endogenous homeostasis with external circadian cues have increased. This change in lifestyle has been linked to increased risk of diseases in all aspects of human health, including cancer. Studies in humans and animal models have revealed that cancer development in vivo is closely associated with the loss of circadian homeostasis in energy balance, immune function and aging that are supported by cellular functions important for tumor suppression including cell proliferation, senescence, metabolism and DNA damage response. The clock controls these cellular functions both locally in cells of peripheral tissues and at the organismal level via extracellular signaling. Thus, the hierarchical mammalian circadian clock provides a unique system to study carcinogenesis as a deregulated physiological process in vivo. The asynchrony between host and malignant tissues in cell proliferation and metabolism also provides new and exciting options for novel anti-cancer therapies.

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“…This uneven distribution of mitosis is a general phenomenon and can be found in the normal tissues of animals. I n contrast, some neoplastic tissues show either absence or a different mitotic rhythm, as reported by many authors (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

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confidence: 69%