Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

Kanfer, Gil; Courthéoux, Thibault; Peterka, Miroslav; Meier, Sonja; Soste, Martin; Melnik, André; Reis, Katarina; Aspenström, Pontus; Peter, Matthias; Picotti, Paola; Kornmann, Benoı̂t

doi:10.1038/ncomms9015

Cited by 92 publications

(157 citation statements)

References 36 publications

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“…This is in stark contrast with other EF-hand proteins, and difficult to reconcile with the strong effects of Ca 2 + on mitochondrial transport. Another observation that we have made is that expressing Ca 2 + -binding mutants of Miro did not yield the same result as artificially lowering cytosolic [Ca 2 + ], suggesting that the mutants do not faithfully mimic Ca 2 + -free Miro [4]. Clearly, more studies are necessary to fully understand Ca 2 + -dependent regulation of Miro-driven mitochondrial transport.…”

Section: The Miro Gtpases Mechanism and Functionmentioning

confidence: 69%

“…First, Cenp-F associates with growing microtubules. In particular, Cenp-F appears to connect mitochondria to polymerizing tips of microtubules, and mitochondria can 'track' growing microtubule tips over distances of a few micrometers in a Cenp-F-dependent manner [4]. The second observation relates to Cenp-F function at the kinetochore.…”

Section: Mitochondrial Transport During Mitosismentioning

confidence: 98%

“…Indeed, while mitochondria congress towards the division plane from anaphase to early cytokinesis, presumably to deliver ATP for the contraction of the actomyosin ring [5], in late cytokinesis/early G 1 , mitochondria are transported away from the division plane and spread towards the periphery of the two daughter cells [4]. This latter phenomenon is dependent on Miro's interaction with a cell-cycle-specific cytoskeletal adaptor, the centromeric protein F (Cenp-F).…”

Section: Mitochondrial Transport During Mitosismentioning

confidence: 99%

“…Cenp-F is a large microtubule-binding protein that mostly consists of coiled coils, as well as of binding sites for various cargo and motor protein adaptors ( Figure 2B). Cenp-F is recruited to mitochondria by Miro in a regulated fashion, at the end of cytokinesis [4]. Failure to recruit Cenp-F to mitochondria causes mitochondria to stay clumped in the perinuclear region of the two daughter cells.…”

Section: Mitochondrial Transport During Mitosismentioning

confidence: 99%

“…In interphase cells, the mitochondria are arranged in elongated tubules whereas in mitosis, the network is fragmented ( Figure 1B). At the exit of mitosis and initiation of cytokinesis, the mitochondria tubules merge again to reform an interconnected network [3] that is distributed across the cell [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Dynamics of the mitochondrial network during mitosis

Kanfer

Kornmann

2016

Biochemical Society Transactions

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During mitosis, cells undergo massive deformation and reorganization, impacting on all cellular structures. Mitochondria, in particular, are highly dynamic organelles, which constantly undergo events of fission, fusion and cytoskeleton-based transport. This plasticity ensures the proper distribution of the metabolism, and the proper inheritance of functional organelles. During cell cycle, mitochondria undergo dramatic changes in distribution. In this review, we focus on the dynamic events that target mitochondria during mitosis. We describe how the cell-cycle-dependent microtubule-associated protein centromeric protein F (Cenp-F) is recruited to mitochondria by the mitochondrial Rho GTPase (Miro) to promote mitochondrial transport and re-distribution following cell division.

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Section: The Miro Gtpases Mechanism and Functionmentioning

confidence: 69%

Section: Mitochondrial Transport During Mitosismentioning

confidence: 98%

Section: Mitochondrial Transport During Mitosismentioning

confidence: 99%

Section: Mitochondrial Transport During Mitosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dynamics of the mitochondrial network during mitosis

Kanfer

Kornmann

2016

Biochemical Society Transactions

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Malformations in the Murine Kidney Caused by Loss of CENP‐F Function

Haley

Waters

Bader

2018

The Anatomical Record

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Centromere‐binding protein F (CENP‐F) is a large and complex protein shown to play critical roles in mitosis and various other interphase functions. Previous studies have shown that the disruption of CENP‐F function leads to detrimental effects on human development. Still, it is important to note the lack of studies focusing on the effects that the loss of this essential protein may have on specific adult organs. In the current study, we used a novel global knockout murine model to analyze the potential consequences deletion of CENP‐F has on adult kidney structure and function. We discovered several structural abnormalities including loss of ciliary structure, tubule dilation, and disruption of the glomerulus. Along with these structural irregularities, renal dysfunction was also detected suggesting hydronephrosis and acute kidney injury in these knockout organs. Importantly, this is the first study linking CENP‐F to kidney disease and hopefully these data will serve as a platform to further investigate the molecular mechanisms disrupted in the kidney by the loss of CENP‐F. Anat Rec, 302:163–170, 2019. © 2018 Wiley Periodicals, Inc.

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Dynamic changes in mitochondrial localization in human neocortical basal radial glial cells during cell cycle

Gkini,

Gómez‐Lozano,

Heikinheimo

et al. 2024

J of Comparative Neurology

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Mitochondria play critical roles in neural stem/progenitor cell proliferation and fate decisions. The subcellular localization of mitochondria in neural stem/progenitor cells during mitosis potentially influences the distribution of mitochondria to the daughter cells and thus their fates. Therefore, understanding the spatial dynamics of mitochondria provides important knowledge about brain development. In this study, we analyzed the subcellular localization of mitochondria in the fetal human neocortex with a particular focus on the basal radial glial cells (bRGCs), a neural stem/progenitor cell subtype attributed to the evolutionary expansion of the human neocortex. During interphase, bRGCs exhibit a polarized localization of mitochondria that is localized at the base of the process or the proximal part of the process. Thereafter, mitochondria in bRGCs at metaphase show unpolarized distribution in which the mitochondria are randomly localized in the cytoplasm. During anaphase and telophase, mitochondria are still localized evenly, but mainly in the periphery of the cytoplasm. Mitochondria start to accumulate at the cleavage furrow during cytokinesis. These results suggest that the mitochondrial localization in bRGCs is tightly regulated during the cell cycle, which may ensure the proper distribution of mitochondria to the daughter cells and, thus in turn, influence their fates.

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Mitotic redistribution of the mitochondrial network by Miro and Cenp-F

Cited by 92 publications

References 36 publications

Dynamics of the mitochondrial network during mitosis

Dynamics of the mitochondrial network during mitosis

Malformations in the Murine Kidney Caused by Loss of CENP‐F Function

Dynamic changes in mitochondrial localization in human neocortical basal radial glial cells during cell cycle

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