Mitotic kinases are emerging therapeutic targets against metastatic breast cancer
Alexandra N. Aquino-Acevedo,
Joel A. Orengo-Orengo,
Melanie E. Cruz-Robles
et al.
Abstract:This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, including triple-negative breast cancer (TNBC). Breast cancer poses a significant global health risk, with TNBC standing out as the most aggressive subtype. Comprehending the role of mitosis is crucial for understanding how TNBC advances from a solid tumor to metastasis. Chemothera… Show more
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