2012
DOI: 10.1158/1078-0432.ccr-11-1610
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Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors

Abstract: Purpose: The importance of KIT and PDGFRA mutations in the oncogenesis of gastrointestinal stromal tumors (GIST) is well established, but the genetic basis of GIST metastasis is poorly understood. We recently published a 67 gene expression prognostic signature related to genome complexity (CINSARC for Complexity INdex in SARComas) and asked whether it could predict outcome in GISTs.Experimental Design: We carried out genome and expression profiling on 67 primary untreated GISTs.Results: We show and validate he… Show more

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Cited by 121 publications
(142 citation statements)
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“…4,[10][11][12][13] Several tumor cell-intrinsic molecular prognosticators have been suggested, mainly based on proteins [47][48][49][50][51] or gene signatures 52,53 related to cell proliferation. Potential immune prognostic/predictive parameters have been more recently reported.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…4,[10][11][12][13] Several tumor cell-intrinsic molecular prognosticators have been suggested, mainly based on proteins [47][48][49][50][51] or gene signatures 52,53 related to cell proliferation. Potential immune prognostic/predictive parameters have been more recently reported.…”
Section: Discussionmentioning
confidence: 99%
“…We collected histoclinical and gene expression data of clinical GIST samples from our 2 databases 57,58 and 3 public data sets 53,59,60 from the National Center for Biotechnology Information (NCBI)/Genbank GEO and ArrayExpress databases. The 5 datasets are described in Table S5.…”
Section: Tumor Samplesmentioning
confidence: 99%
“…12 The array comparative genomic hybridization (aCGH) data from 54 GIST included in this study were published before by our group. 14,15 Mutational analysis of the entire coding sequence of PTEN (ENST00000371953-exons 1-9) was performed as described. 12 The primer sequences are listed in Table 2.…”
Section: Pten Copy Number Loss Mutational Analysis and Methylation mentioning
confidence: 99%
“…The genomic signature (genomic index) is a powerful predictor of metastatic relapse, as is the CINSARC signature. 17 Further, this array-CGH technique is adapted to formalin-fixed paraffin-embedded tumor material and its efficacy has been demonstrated on tumor samples that have been archived for over 15 years.…”
mentioning
confidence: 99%