Mitotic Antipairing of Homologous Chromosomes

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

“…The two discrete peaks of centromeric components found in the present study and the haploid set-based segregation of homologous chromosomes during cell division ( Hua et al 2022 ) lead to the question of how the spatial restriction of chromosome movement and positioning is regulated during the cell cycle. The current work is an initial step to address this obvious question by analyzing dynamics of centromere oscillation and movement.…”

“…Chromosomes are highly organized structures within the nucleus of the cell ( Cooper 2000 ). Multiple studies have investigated the distribution of chromosomes across various human cell types, and have proposed different models for individual chromosome organization ( Hua et al 2022 ). Interphase chromosome organization is radially distributed in the nucleus in what was originally thought to be random patterns ( Emmerich et al 1989 ; Lesko et al 1995 ), but is increasingly correlated with factors such as chromosome size, gene density, or heterochromatic content ( Cremer et al 2001 ; Bolzer et al 2005 ; Bridger et al 2000 ; Boyle et al 2001 ; Kupper et al 2007 ).…”

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

“…The two discrete peaks of centromeric components found in the present study and the haploid set-based segregation of homologous chromosomes during cell division [2] lead to the question of how the spatial restriction of chromosome movement and positioning is regulated during the cell cycle. The current work is an initial step to address this obvious question by analyzing dynamics of centromere oscillation and movement.…”

“…As mentioned, a molecular or cytoskeletal barrier or cage could work together with the IcL-DZ to partition or encapsulate the chromosomes within each haploid set. Parental origin or epigenetic identity may also be implicated in haploid set organization (Hua et al, 2022). Previously, we have shown that a maternally derived translocation chromosome segregates within the same nuclear hemisphere as the X chromosome in male mouse fibroblasts (Hua and Mikawa, 2018).…”

“…Chromosomes are highly organized structures within the nucleus of the cell (Cooper, 2000). Multiple studies have investigated the distribution of chromosomes across various human cell types, and have proposed different models for individual chromosome organization (reviewed in Hua et al, 2022). Interphase chromosome organization is radially distributed in the nucleus in what was originally thought to be random patterns (Emmerich et al, 1989; Lesko et al, 1995), but is increasingly correlated with factors such as chromosome size, gene density, or heterochromatic content (Cremer et al, 2001; Bolzer et al, 2005; Bridger et al, 2000; Boyle et al, 2001; Küpper et al, 2007).…”