Mitotic activity in vaginal epithelium in neonatally androgenized mice following estrogen administration.

Iguchi, Taisen

doi:10.2183/pjab.53.113

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

1977

DOI: 10.2183/pjab.53.113

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Mitotic activity in vaginal epithelium in neonatally androgenized mice following estrogen administration.

Taisen Iguchi

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1979

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Cited by 3 publications

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Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero

Mittendorf

1995

Teratology

130

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Exposure of the human fetus to physician-prescribed diethylstilbestrol and other synthetic estrogens (collectively referred to as "DES") led to an important iatrogenic epidemic. In the United States alone, at least four million fetuses and their mothers had a substantial exposure to these estrogens now known to be mild carcinogens and potent teratogens. Mothers exposed to DES may have a somewhat higher risk of breast cancer than women who were not exposed. The sequelae of in utero exposure of daughters include clear cell adenocarcinoma of the vagina and cervix, various gross anomalies of the genital tract that are associated with adverse outcomes of pregnancy, vaginal adenosis and other vaginal epithelial changes, and other possible health effects that have not yet been fully evaluated. Among sons exposed in utero to DES, no increase in the incidence of any cancer has been reported, but several anomalies of the genital tract have been described, and it is possible that some social behaviors are modified. Although the grandchildren of the DES-exposed daughters and sons have not been shown to have any abnormalities, some of them have been the products of short gestations. Future research, being funded by the National Cancer Institute, will permit monitoring of the DES-exposed population to determine whether any other abnormalities will become apparent in them.

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Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero

Mittendorf

1995

Teratology

130

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Blockade by vitamin A of the occurrence of permanent vaginal changes in mice treated neonatally with 5?-dihydrotestosterone

Iguchi

Takasugi

1979

Anat Embryol

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Estrogen-independent, persistent proliferation and cornification of the vaginal epithelium occurred in ovariectomized adult mice which had received neonatal injections of 50 microgram 5alpha-dihydrotestosterone (DHT). The occurrence of the permanent vaginal changes was prevented by injections of 200 IU vitamin A acetate (VA) given simultaneously with DHT. In 45% of the DHT plus VA-treated, ovariectomized mice, clear cells with pale cytoplasm appeared in the basal layer of the degenerating epithelium, while they came out in the epithelium of 13% of the ovariectomized mice receiving neonatal injections of DHT alone. For suppressing the permanent vaginal changes, including high mitotic rate, more than 1 month was required after the combined treatment. However, the occurrence of the permanent changes was not blocked by VA given after the DHT treatment. Permanent proliferation and squamous metaplasia took place in the uterine epithelium of the DHT-treated mice. Neonatal injections of VA also prevented the occurrence of the permanent uterine changes when given simultaneously with DHT but not when given after the androgen treatment.

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New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs

et al. 2021

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Mitotic activity in vaginal epithelium in neonatally androgenized mice following estrogen administration.

Cited by 3 publications

References 2 publications

Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero

Teratogen update: Carcinogenesis and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero

Blockade by vitamin A of the occurrence of permanent vaginal changes in mice treated neonatally with 5?-dihydrotestosterone

New frontiers of developmental endocrinology opened by researchers connecting irreversible effects of sex hormones on developing organs

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