Mitosis in neoplastic and hyperplastic imaginal discs ofDrosophila

Mishra, Amodini; Radhakrishnan, V.; Sardesai, Sunita; Agrawal, Namita; Sinha, Prawal

doi:10.1007/bf02932219

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How Closely Do the Fly Tumors Resemble Human Tumors?1

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2004

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“…Resistance to apoptosis does not therefore seem to make a major contribution to overproliferation. Genetic instability, seen in many malignant human tumors, has not been strongly noted in fly tumors (Mishra et al 1997), nor have cytological differences such as increased nuclear or nucleolar size. A fly analog of angiogenic behavior is the recruitment of new tracheal branches to proliferating cells.…”

Section: How Closely Do the Fly Tumors Resemble Human Tumors?mentioning

confidence: 99%

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

Bilder¹

2004

Genes Dev.

515

510

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Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether polarity loss might causally contribute to cancer has remained unclear. In Drosophila, mutations in the "neoplastic tumor suppressor genes" (nTSGs) scribble, discs-large, and lethal giant larvae disrupt polarity of epithelia and neuroblasts, and simultaneously induce extensive overproliferation of these cells, which exhibit malignant-like characteristics. Herein I review what is known about the role of the fly nTSGs in controlling cell polarity and cell proliferation. Incorporating data from mammalian studies, I consider how polarity and proliferation can be coupled, and how disruption of polarity could promote cancer.

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Section: How Closely Do the Fly Tumors Resemble Human Tumors?mentioning

confidence: 99%