Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection

Song, Sihyeong; Satta, Sandro; Sharma, Madhav; Hugo, Cristelle; Kossyvakis, Athanassios; Roy, Shubhendu Sen; Kelesidis, Theodoros

doi:10.1093/infdis/jiad044

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Recently, mitochondrial antioxidant MitoQ (mitoquinone mesylate) has been shown to reduce ART and HIVassociated mitochondrial dysfunction in a humanized murine model. 236 Additionally, NAC, a potent antioxidant, reduced agents like coenzyme Q10, 237 which supports mitochondrial electron transport and reduces oxidative stress, or novel compounds that enhance mitochondrial biogenesis and function, could be integrated into HIV treatment regimens. New regimens should dualistically aim to reduce HIV-related inflammation and ART-induced toxicity with improved clinical outcomes.…”

Section: Antioxidants and Oxphosmentioning

confidence: 99%

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

Hinton,

N’jai,

Vue

et al. 2024

Circulation Research

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HIV infection and antiretroviral therapy alter mitochondrial function, which can progressively lead to mitochondrial damage and accelerated aging. The interaction between persistent HIV reservoirs and mitochondria may provide insight into the relatively high rates of cardiovascular disease and mortality in persons living with HIV. In this review, we explore the intricate relationship between HIV and mitochondrial function, highlighting the potential for novel therapeutic strategies in the context of cardiovascular diseases. We reflect on mitochondrial dynamics, mitochondrial DNA, and mitochondrial antiviral signaling protein in the context of HIV. Furthermore, we summarize how toxicities related to early antiretroviral therapy and current highly active antiretroviral therapy can contribute to mitochondrial dysregulation, chronic inflammation, and poor clinical outcomes. There is a need to understand the mechanisms and develop new targeted therapies. We further consider current and potential future therapies for HIV and their interplay with mitochondria. We reflect on the next-generation antiretroviral therapies and HIV cure due to the direct and indirect effects of HIV persistence, associated comorbidities, coinfections, and the advancement of interdisciplinary research fields. This includes exploring novel and creative approaches to target mitochondria for therapeutic intervention.

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Section: Antioxidants and Oxphosmentioning

confidence: 99%

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

Hinton,

N’jai,

Vue

et al. 2024

Circulation Research

View full text Add to dashboard Cite

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Decrypting biological hallmarks of aging in people with HIV

Premeaux

Ndhlovu

2023

Current Opinion in HIV and AIDS

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Purpose of review HIV infection adds further complexity to the heterogenous process of aging. In this focused review, we examine and discuss recent advances to better elucidate mechanisms of biological aging perturbed and accelerated in the context of HIV, particularly among those with viral suppression through the benefits of antiretroviral therapy (ART). New hypotheses from these studies are poised to provide an improved understanding of multifaceted pathways that converge and likely form the basis for effective interventions toward successful aging. Recent findings Evidence to date suggests multiple mechanisms of biological aging impact people living with HIV (PLWH). Recent literature delves and expands on how epigenetic alterations, telomere attrition, mitochondrial perturbations, and intercellular communications may underpin accelerated or accentuated aging phenotypes and the disproportionate prevalence of age-related complications among PLWH. Although most hallmarks of aging are likely exacerbated in the setting of HIV, ongoing research efforts are providing new insight on the collective impact these conserved pathways may have in the aging disease processes. Summary New knowledge on underlying molecular disease mechanisms impacting people aging with HIV are reviewed. Also examined are studies that may facilitate the development and implementation of effective therapeutics and guidance on improving geriatric HIV clinical care.

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Mitoquinone Mesylate and Mitochondrial DNA in End Organs in Humanized Mouse Model of Chronic Treated Human Immunodeficiency Virus Infection

Cited by 2 publications

References 15 publications

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

Connection Between HIV and Mitochondria in Cardiovascular Disease and Implications for Treatments

Decrypting biological hallmarks of aging in people with HIV

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